“…This reaction also provides straightforward access to aminocyclitol scaffolds that frequently occur as core structures in numerous biologically active molecules including peramivir (antiviral), pactamycin (antibiotic), and trehazolin (glycosidase inhibitor) . Recently, a series of elegant Lewis/Brønsted-acid-based catalytic systems have been developed to address the issues of reaction efficiency and stereocontrol. , However, despite these successes, the introduction of functional groups (such as ketone, aldehyde, ester, halogen, hydroxyl, and amino groups) at the 5-substituents of 4-aminocyclopentenones via these two-component reaction processes is still challenging due to the difficulty for the prefunctionalization of furfuryl alcohols.…”