Retracted: Wogonoside promotes apoptosis in gastric cancer AGS and SGC‐7901 cells through induction of mitochondrial dysfunction and endoplasmic reticulum stress

Abstract

Wogonoside (Wg), a natural flavonoid, has anticancer effects against several human cancers. The purpose of the present study was to investigate the antitumor effects and underlying mechanisms of Wg on gastric cancer (GC) cell lines. We report that Wg treatment inhibited cell viability and induced apoptosis in human GC cell lines AGS and SGC‐7901, and also retarded GC tumor growth in xenograft mice in vivo. We also found that the Wg exerted its antitumor effects against GC cells via induction of reaction oxygen species accumulation, mitochondrial dysfunction, and endoplasmic reticulum stress. Furthermore, C/EBP homologous protein knockdown inhibited apoptosis and increased the viability of Wg‐treated GC cells. Our findings may facilitate the development of novel therapeutic agents for the treatment of GC.

Retraction: Downregulation of OIP5-AS1 affects proNGF-induced pancreatic cancer metastasis by inhibiting p75NTR levels

“…We found overlap between some of the transwell assay images used in Figures 5F, 6F, 6H, 7G and data published by other authors at earlier date [1]. We also found that images of wound healing assay presented in Figure 7D, F duplicate images published in unrelated papers [2,3], and identical images of Western blots in Figure 6K are presented in two unrelated papers [2,4]. The authors informed Aging that all these issues cannot be resolved and agreed to retract the article.…”

Scutellarin Inhibits the Growth and EMT of Gastric Cancer Cells through Regulating PTEN/PI3K Pathway

“…For example, baicalin inhibits the proliferation and aggravates the apoptosis of gastric cancer cells (BGC-823 and MGC-803) via downregulating Bcl-2. 20) Wogonoside (Wg) mitigated cell viability and induced apoptosis in human GC cell lines AGS and SGC-7901 through induction of reaction oxygen species accumulation, mitochondrial dysfunction, and endoplasmic reticulum stress. 21) What is more, Wogonin potentiates gastric cancer cells to 5-fluorouracil therapy through attenuating the activation of nuclear factor-kappa B (NF-kappaB) pathway.…”

Retraction Note: IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way

“… Fig. 2F contains multiple panels that seem to overlap with panels in Fig 1C a previously-published paper by different authors [ 3 ], Fig 1D in a previously-published paper by different authors [ 4 ], as well as Fig 5E, 6E and 7H in a paper by different authors that was under submission at the same time [ 1 ]. Fig.…”