Retracted: The lncRNA SNHG5‐mediated miR‐205‐5p downregulation contributes to the progression of clear cell renal cell carcinoma by targeting ZEB1

Abstract

Renal cell carcinoma (RCC) is a common form of urological tumors, accounting for nearly 3% of human malignancies worldwide. 1 Based on histological and cytogenetic features, clear cell renal cell carcinoma (ccRCC) has been demonstrated to be the most common subtype of RCC. 2 Due to resistance to traditional chemo-and radiotherapeutic strategies, surgical removal is still the primary treatment option for ccRCC. However, ccRCC patients exhibit a poor prognosis owing to the high incidence of recurrence and metastasis. Approximately 25% of ccRCC patients will experience local

<p>Latest Advances of Long Non-Coding RNA SNHG5 in Human Cancers</p>

“…Concluding from the analysis from The Cancer Genome Atlas (TCGA) database and 72 pairs of human RCC tissues and nontumor tissues, SNHG5 was significantly elevated in RCC tissues, which was also positively correlated with tumornode-metastasis (TNM) stage, tumor size, lymphatic invasion, and distant metastasis. 35,36 Similar high expression of SNHG5 was also detected in RCC cell lines, including ACHN, 786-O, SW13 and Caki-1. 36 Subsequent in-vitro experiments disclosed that SNHG5 knockdown suppressed RCC cellular proliferation, migration and invasion.…”

“…36 Subsequent in-vitro experiments disclosed that SNHG5 knockdown suppressed RCC cellular proliferation, migration and invasion. 35 More importantly, SNHG5 was involved in the epithelial-mesenchymal transition (EMT) process and apoptotic response. 35,36 In xenograft models of RCC cells, SNHG5 laid an obvious suppressive effect on tumor volume, weight and pulmonary metastatic nodules.…”

“…35 More importantly, SNHG5 was involved in the epithelial-mesenchymal transition (EMT) process and apoptotic response. 35,36 In xenograft models of RCC cells, SNHG5 laid an obvious suppressive effect on tumor volume, weight and pulmonary metastatic nodules. 35 Mechanically, SNHG5 targeted miR-205-5p/zinc finger E-box binding homeobox 1 (ZEB1) axis 35 or miR-363-3p-Twist1 interaction 36 to affect cellular invasion and apoptosis.…”

Long non‑coding RNA NEAT1 promotes ovarian cancer cell invasion and migration by interacting with miR‑1321 and regulating tight junction protein 3 expression

“…In recent years, the relationship between lncRNA and tumor EMT has been widely reported, and numerous lncRNAs have been shown to promote the EMT process via different molecular mechanisms in several tumors. For instance, lncRNA SNHG5 induces zinc finger E-box binding homeobox 1 expression by competitively inhibiting microRNA (miRNA/miR)-205-5p, thus promoting the EMT process in clear cell renal cell carcinoma (20). Furthermore, lncRNA AFAP1-AS1 promotes the EMT process of liver cancer by acting on the oncogenic protein CRKL-mediated Ras/mitogen-activated protein kinase kinase/c-Jun and the cadherin/vimentin signaling pathway (21), while lncRNA ROR1-AS1 promotes the EMT process of cervical cancer via the Wnt/β-catenin pathway (22).…”

Multivariate gene expression‐based survival predictor model in esophageal adenocarcinoma

“…25,26 ceRNA hypothesis provides an in-depth understanding of the mechanism of carcinogenesis and new evidence for cancer diagnosis and treatment, chemotherapy efficacy prediction and cancer risk prediction. 6,27,28 Data mining using TCGA database is an effective approach to identify changes in RNA expression that are relevant to clinical outcomes and to screen new therapeutic targets. While ceRNAs have been studied more in the past decades, few studies have evaluated the prognostic value of ceRNA for EAC patients using TCGA database.…”