<i>Retracted:</i> Quercetin Decreases Liver Damage in Mice with Non‐Alcoholic Steatohepatitis

Marcolin, Éder; Forgiarini, Luiz Felipe; Rodrigues, Graziella; Tieppo, Juliana; Borghetti, Greice Stefani; Bassani, Valquíria Linck; Picada, Jaqueline Nascimento; Marroni, Norma Possa

doi:10.1111/bcpt.12049

Cited by 44 publications

(28 citation statements)

References 59 publications

(64 reference statements)

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“…13 However, we observed a significant reduction in DNA damage in groups treated with quercetin. This result is consistent with results presented by Marcolin et al, 68 which demonstrated the protective role of quercetin in an experimental model of nonalcoholic steatohepatitis. 68 These results indicate that quercetin scavenges ROS, thereby, decreasing DNA breaks and oxidized bases.…”

Section: Discussionsupporting

confidence: 93%

Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

Saccol

Silveira

Manzoni

et al. 2019

J of Cellular Biochemistry

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Rheumatoid arthritis is a highly debilitating inflammatory autoimmune disease which is characterized by joint destruction. The present study sought to investigate the effect of quercetin in rats with complete Freund's adjuvant‐induced arthritis. Animals were divided into control/saline, control/quercetin (5 mg/kg, 25 mg/kg, and 50 mg/kg) arthritis/saline, and arthritis/quercetin (5 mg/kg, 25 mg/kg, and 50 mg/kg); the treatments were administered for 45 days. Biochemical, oxidative stress, genotoxicity, and cytotoxicity parameters were evaluated. All doses of quercetin reduced the levels of aspartate aminotransferase, thiobarbituric acid‐reactive substances, and reactive oxygen species; however, only treatment with 25 or 50 mg/kg increased catalase activity. Total thiol and reduced glutathione levels were not significantly affected by the induction nor by the treatments. Genotoxicity assessed by DNA damage, and cytotoxicity through picogreen assay, decreased after treatments with quercetin. Our results present evidence of the antioxidant, cytoprotective, genoprotective and hepatoprotective, and effects of quercetin, demonstrating its potential as a candidate for coadjuvant therapy.

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Section: Discussionsupporting

confidence: 93%

Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

Saccol

Silveira

Manzoni

et al. 2019

J of Cellular Biochemistry

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“…The increase in AST values pp was considerably less in the Q-treated cows than in the CTR cows. This observation was similar to findings for mice and rats with nonalcoholic steatohepatitis and cirrhosis, respectively, in which Q supplementation inhibited the development of steatosis and reduced levels of AST (Peres et al, 2000;Marcolin et al, 2013). Because AST is not liverspecific, we also measured the plasma activity of CK (Kalaitzakis et al, 2010).…”

supporting

confidence: 86%

Effects of a 6-wk intraduodenal supplementation with quercetin on energy metabolism and indicators of liver damage in periparturient dairy cows

Stoldt

Derno

Nürnberg

et al. 2015

Journal of Dairy Science

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Periparturient dairy cows experience metabolic challenges that result in a negative energy balance (EB) and a range of postpartum health problems. To compensate for the negative EB, cows mobilize fatty acids from adipose tissues, which can lead to fatty liver disease, a periparturient metabolic disorder. Flavonoids, such as quercetin (Q), are polyphenolic substances found in all higher plants and have hepatoprotective potential and the ability to prevent or reduce lipid accumulation in the liver. In ruminants, few studies on the metabolic effects of Q are available, and thus this study was conducted to determine whether Q has beneficial effects on EB, lipid metabolism, and hepatoprotective effects in periparturient dairy cows. Quercetin was supplemented intraduodenally to circumvent Q degradation in the rumen. Cows (n=10) with duodenal fistulas were monitored for 7wk. Beginning 3wk before expected calving, 5 cows were treated with 100mg of quercetin dihydrate per kilogram of body weight daily in a 0.9% sodium chloride solution for a total period of 6wk, whereas the control cows received only the sodium chloride solution. The plasma flavonoid levels were higher in the Q-treated cows than in the control cows. A tendency for higher postpartum (pp) than antepartum (ap) plasma flavonoid levels was observed in the Q-treated cows than in the controls, which was potentially caused by a reduced capacity to metabolize Q. However, the metabolic status of the Q-treated cows did not differ from that of the control cows. The pp increases in plasma aspartate aminotransferase and glutamate dehydrogenase activities were less in the Q-treated cows than in the control cows. The Q had no effect on energy expenditures, but from ap to pp the cows had a slight decline in respiratory quotients. Irrespective of the treatment group, the oxidation of fat peaked after calving, suggesting that the increase occurred because of an increased supply of fatty acids from lipomobilization. In conclusion, supplementation with Q resulted in lower pp plasma aminotransferase and glutamate dehydrogenase, which indicated reduced liver damage. However, the direct effects of Q on the liver and the implications for animal performance remain to be investigated.

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“…The authors attributed the changes to a reduction in oxidative stress and inflammation as a result of the quercetin‐induced upregulation of ‘nuclear factor erythroid 2–related factor 2’ (Nrf2) and downregulation of ‘nuclear factor kappa‐light‐chain‐enhancer of activated B cells’ (NF‐ κβ ), thus promoting antioxidant and anti‐inflammatory mechanisms, respectively . Similarly, Marcolin et al . observed a significant reduction in hepatic macro‐ and microvesicular steatosis, as well as liver enzymes ALT and AST, in male CB57BL6 mice fed a methionine‐ and choline‐deficient diet (MCD) together with quercetin (50 mg kg −1 ) for a period of 4 weeks, compared to those only receiving the MCD diet.…”

Section: Discussionmentioning

confidence: 96%

Quercetin administration post‐weaning attenuates high‐fructose, high‐cholesterol diet‐induced hepatic steatosis in growing, female, Sprague Dawley rat pups

et al. 2019

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BACKGROUND Fructose and cholesterol‐rich diets have been implicated in the upsurge of metabolic syndrome (MetS). Phytochemicals are being explored as alternatives for the prevention and management of MetS. Thirty‐six 21‐day‐old, female Sprague Dawley rats fed a high‐fructose, high‐cholesterol diet post‐weaning were used to investigate the prophylactic potential of quercetin. Group 1 was given standard rat chow (SRC); Group 2: SRC and quercetin (75 mg kg−1 daily); Group 3: SRC and fenofibrate (100 mg kg−1 daily); Group 4 was given a high cholesterol diet (HCD) (2% added dietary cholesterol in SRC), 20% fructose drinking solution (FS); Group 5 was given HCD, 20% FS and quercetin (75 mg kg−1 daily); Group 6: HCD, 20% FS and fenofibrate (100 mg kg−1 daily). Rats were fed ad libitum for 8 weeks, euthanized, and blood and liver samples were collected. RESULTS The HCD and FS significantly increased (P < 0.05) absolute and relative liver masses and serum cholesterol. Fasting blood glucose, serum triglycerides, alanine transaminase, creatinine, and urea were not significantly different (P > 0.05) between groups. The HCD and FS significantly increased liver lipid yield compared to the SRC and rats receiving SRC with fenofibrate (P < 0.05). Quercetin or fenofibrate together with HCD and FS attenuated the diet‐induced increase in liver lipids by approximately 50%, although this was not statistically significant. Liver macro‐ and micro‐steatosis scores were significantly increased (P < 0.05) in rats receiving HCD and FS. Quercetin or fenofibrate administration together with HCD and FS significantly decreased (P < 0.05) liver macro‐steatosis scores. CONCLUSION The prophylactic effect of quercetin on fructose and cholesterol diet‐induced liver lipid accumulation may be exploited in the fight against non‐alcoholic fatty liver disease (NAFLD). © 2019 Society of Chemical Industry

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Retracted: Quercetin Decreases Liver Damage in Mice with Non‐Alcoholic Steatohepatitis

Cited by 44 publications

References 59 publications

Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

Effects of a 6-wk intraduodenal supplementation with quercetin on energy metabolism and indicators of liver damage in periparturient dairy cows

Quercetin administration post‐weaning attenuates high‐fructose, high‐cholesterol diet‐induced hepatic steatosis in growing, female, Sprague Dawley rat pups

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