<i>Retracted:</i> Mechanisms and effects of curcumin on spatial learning and memory improvement in APPswe/PS1dE9 mice

Wang, Pengwen; Su, Chung‐Kuang; Li, Ruisheng; Wang, Hong; Ren, Ying; Sun, Haitao; Yang, Jing; Sun, Jing; Shi, Jing; Tian, Jinzhou; Jiang, Shucui

doi:10.1002/jnr.23322

Cited by 64 publications

(65 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…29 We have previously reported that curcumin improves the spatial learning and memory abilities of APPswe/ PS1dE9 double transgenic mice. 23 Therefore, we sought to determine whether curcumin affects the pathology of AD via the synapses. Specifically, we sought to determine whether curcumin influences the structures and functions of the synapses of APPswe/PS1dE9 double transgenic mice.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of curcumin on synapses in APPswe/PS1dE9 mice

Wang

Wei

et al. 2016

Int J Immunopathol Pharmacol

Self Cite

View full text Add to dashboard Cite

Significant losses of synapses have been demonstrated in studies of Alzheimer's disease (AD), but structural and functional changes in synapses that depend on alterations of the postsynaptic density (PSD) area occur prior to synaptic loss and play a crucial role in the pathology of AD. Evidence suggests that curcumin can ameliorate the learning and memory deficits of AD. To investigate the effects of curcumin on synapses, APPswe/PS1dE9 double transgenic mice (an AD model) were used, and the ultra-structures of synapses and synapse-associated proteins were observed. Six months after administration, few abnormal synapses were observed upon electron microscopy in the hippocampal CA1 areas of the APPswe/PS1dE9 double transgenic mice. The treatment of the mice with curcumin resulted in improvements in the quantity and structure of the synapses. Immunohistochemistry and western blot analyses revealed that the expressions of PSD95 and Shank1 were reduced in the hippocampal CA1 areas of the APPswe/PS1dE9 double transgenic mice, but curcumin treatment increased the expressions of these proteins. Our findings suggest that curcumin improved the structure and function of the synapses by regulating the synapse-related proteins PSD95 and Shank1.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The following doses were used in the curcumin treatment groups: the low-dose curcumin group (LDC) received 100 mg/kg/day, the medium-dose curcumin group (MDC) received 200 mg/kg/day, and the high-dose curcumin group (HDC) received 400 mg/kg/day. 23 …”

Section: Animalsmentioning

confidence: 99%

Effects of curcumin on synapses in APPswe/PS1dE9 mice

Wang

Wei

et al. 2016

Int J Immunopathol Pharmacol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Then, we placed the cryovials into liquid nitrogen to freeze them and subsequently stored them at −80°C until the tissues were used for a western blot analysis. 9 …”

Section: Tissue Preparationmentioning

confidence: 99%

“…12 The CA1 region of the hippocampus is the core functional area of learning and memory; therefore, we chose this region of the APPswe/PS1dE9 double transgenic mice as the research object. 13 9 The experiments were strictly performed abiding by the regulations and the guidelines of Beijing for the use of animals in research, and we received permission from the Animal Research Ethics Board of Dongzhimen Hospital. The mice were kept in a temperature-controlled environment with 12 h of light and 12 h of dark.…”

Section: Introductionmentioning

confidence: 99%

Curcumin ameliorates insulin signalling pathway in brain of Alzheimer’s disease transgenic mice

Feng

Dang

Fan

et al. 2016

Int J Immunopathol Pharmacol

Self Cite

View full text Add to dashboard Cite

Deficits in glucose, impaired insulin signalling and brain insulin resistance are common in the pathogenesis of Alzheimer's disease (AD); therefore, some scholars even called AD type 3 diabetes mellitus. Curcumin can reduce the amyloid pathology in AD. Moreover, it is a well-known fact that curcumin has anti-oxidant and anti-inflammatory properties. However, whether or not curcumin could regulate the insulin signal transduction pathway in AD remains unclear. In this study, we used APPswe/PS1dE9 double transgenic mice as the AD model to investigate the mechanisms and the effects of curcumin on AD. Immunohistochemical (IHC) staining and a western blot analysis were used to test the major proteins in the insulin signal transduction pathway. After the administration of curcumin for 6 months, the results showed that the expression of an insulin receptor (InR) and insulin receptor substrate (IRS)-1 decreased in the hippocampal CA1 area of the APPswe/PS1dE9 double transgenic mice, while the expression of phosphatidylinositol-3 kinase (PI3K), phosphorylated PI3K (p-PI3K), serine-threonine kinase (AKT) and phosphorylated AKT (p-AKT) increased. Among the curcumin groups, the medium-dose group was the most effective one. Thus, we believe that curcumin may be a potential therapeutic agent that can regulate the critical molecules in brain insulin signalling pathways. Furthermore, curcumin could be adopted as one of the AD treatments to improve a patient's learning and memory ability.

show abstract

“…In a 4 weeks randomized, double-blind, placebo-controlled human trial, curcumin (400 mg) has been shown to significantly improve working memory and mood after treatment [35]. In animal studies of curcumin in APPswe/PS1dE9 double transgenic AD mice also showed improved spatial learning and memory ability [36,37]. Such effects may conducted through reducing Aβ40, Aβ42, and aggregation of Aβ-derived diffusible ligands in the mouse hippocampal CA1 area, increase the expression of synapse-related proteins PSD95 and Shank1 and improve structure and plasticity of synapse.…”

mentioning

confidence: 99%