Retracted: Long noncoding RNA HCG22 suppresses proliferation and metastasis of bladder cancer cells by regulation of PTBP1

Abstract

Multifarious biological functions of long noncoding RNAs (lncRNAs) have been reported in various cancers including bladder cancer (BCa). This study aims to determine the biological role of a certain lncRNA in BCa. Consistent with the data of The Cancer Genome Atlas database, it was validated that lncRNA HLA complex group 22 (HCG22) was weakly expressed in BCa samples and lowly expressed HCG22 was closely correlated with low overall survival of the BCa patient. To verify the role of HCG22 in BCa progression, functional experiments were carried out in two representative BCa cells (J82 and T24) and the negative effects of HCG22 expression on the cell proliferation, migration, and epithelial-mesenchymal transition were identified. Mechanistically, polypyrimidine tract-binding protein 1 (PTBP1), which was highly expressed in BCa tissues and cell lines, was negatively regulated by HCG22 and the PTBP1-mediated Warburg effect was also obstructed by HCG22. Furthermore, HCG22 modulated the expression of PTBP1 through destabilizing human antigen R (HuR). And functional rescue assays confirmed that HCG22 functioned in bladder cancer through downregulating PTBP1. In conclusion, the present study revealed that HCG22 inhibited BCa progression via the HuR/PTBP1 axis, opening new prospects for potent therapeutic regimens for BCa patients. K E Y W O R D S bladder cancer, HCG22, HuR, PTBP1

LncRNA PITPNA‐AS1 boosts the proliferation and migration of lung squamous cell carcinoma cells by recruiting TAF15 to stabilize HMGB3 mRNA

“…12 LncRNA HCG22 represses the proliferation and metastasis of bladder cancer cells via PTBP1. 13 TATA-box binding protein associated factor 15 (TAF15) belongs to the TET family of RBPs. Although a previous study has explained the tumor-specific role of TAF15, 14 more investigations of TAF15 in human cancers are requisite.…”

A novel long non-coding RNA GK-IT1 promotes the carcinogenesis and progression of esophageal squamous cell carcinoma via mediating the phosphorylation of MAPK1

“…clari ed the carcinogenic role of the CCDC144NL-AS1/miR-143-3p/MAP3K7 axis in the progression of gastric cancer [24]. additionally, lots of lncRNAs can also regulate RNA-binding proteins to in uence cancer progression, including RMST [25], HCG22 [26] and SNHG14 [27]. Here, we identi ed and veri ed several interacting protein partners of GK-IT1, including CDK1, MAPK1 and PABPC1.…”

Construction and analysis of the lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in oral cancer

“…HCG22 (HLA complex group 22) is a long non-coding RNA gene that has been found to be downregulated in oral cancer recently (55). Low-expression of HCG22 has been con rmed to be associated with several types of diseases, including esophageal squamous cell carcinoma (56), bladder cancer (57), and steroid-induced ocular hypertension (58).Consistent with another previous study(59), we identi ed that the low expression level of lncRNA HCG22 was associated with poor survival in oral cancer. However, there is no experimental evidence to support the contribution of HCG22 to the development of oral cancer.…”