<i>Retracted:</i> IFITM3 promotes hepatocellular carcinoma invasion and metastasis by regulating MMP9 through p38/MAPK signaling

Min, Jiaqi; Feng, Qian; Liao, Wenjun; Liang, Yiming; Gong, Chengwu; Li, Enliang; He, Wenfeng; Yuan, Rongfa; Wu, Linquan

doi:10.1002/2211-5463.12479

Cited by 42 publications

(54 citation statements)

References 31 publications

(50 reference statements)

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“…To examine the detailed mechanisms underlying M2 macrophages' role in regulating HCC cells invasion and migration, we tested the expression of proteins that have been connected with cancer cell invasion and migration [12][13][14][15][16][17][18] in both culture alone and in co-culture. The exploratory experiments led to the focus on MMP9 as the results showed that MMP9 protein expression was increased after co-culture, both in SK-HEP-1 and HA22T HCC cells ( Fig.…”

Section: Mechanism Dissection Of How M2 Macrophages Increase the Hcc mentioning

confidence: 99%

M2 Macrophages Promote HCC Cells Invasion and Migration via miR-149-5p/MMP9 Signaling

Liu¹,

Yin²,

Ouyang³

et al. 2020

J. Cancer

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The roles of M2 macrophages on promoting tumor progression and chemotherapy resistance have been well studied in many cancers, such as pancreatic cancer, kidney cancer and so on, but its linkage to HCC cells still remains unclear. Here we found that M2 macrophages could alter miR-149-5p to increase MMP9 expression in HCC cells and mechanism dissection revealed that miR-149-5p might directly target the 3'UTR of MMP9-mRNA to suppress its translation. The in vivo orthotopic xenografts mouse model with oemiR-149-5p also validated in vitro data. Together, these findings suggest that M2 macrophages may through altering the miR-149-5p to promote HCC progression and targeting the M2 macrophages/ miR149-5P/MMP9 signaling may help in the development of the novel therapies to better suppress the HCC progression.

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Section: Mechanism Dissection Of How M2 Macrophages Increase the Hcc mentioning

confidence: 99%

M2 Macrophages Promote HCC Cells Invasion and Migration via miR-149-5p/MMP9 Signaling

Liu¹,

Yin²,

Ouyang³

et al. 2020

J. Cancer

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“…Lue et al described how MAPK is upregulated by heparin-binding epidermal growth factor (HB-EGF)-mediated signaling, in which the HB-EGF is cut from the PCa surface by the zinc transporter, ZIP6 (LIV-1), which stimulates matrix metalloproteinase (MMP)-2/9 upregulation in other PCa cells [11]. Interferon (INF)-induced transmembrane protein 3 (IFITM3), a highly expressed transmembrane protein in cancer cells, is believed to be associated with metastasis in various cancers, e.g., acute myeloid leukemia, hepatomas, and gliomas [12][13][14][15]. In PCa, IFITM3 promotes fibroblast growth factor (FGF) expression and promotes TGF-β production, which elicits the EMT in neighboring cells in a paracrine manner [16].…”

Section: Tgf-β/mapk-mediated Emtmentioning

confidence: 99%

Ras and Wnt Interaction Contribute in Prostate Cancer Bone Metastasis

2020

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Prostate cancer (PCa) is one of the most prevalent and malignant cancer types in men, which causes more than three-hundred thousand cancer death each year. At late stage of PCa progression, bone marrow is the most often metastatic site that constitutes almost 70% of metastatic cases of the PCa population. However, the characteristic for the osteo-philic property of PCa is still puzzling. Recent studies reported that the Wnt and Ras signaling pathways are pivotal in bone metastasis and that take parts in different cytological changes, but their crosstalk is not well studied. In this review, we focused on interactions between the Wnt and Ras signaling pathways during each stage of bone metastasis and present the fate of those interactions. This review contributes insights that can guide other researchers by unveiling more details with regard to bone metastasis and might also help in finding potential therapeutic regimens for preventing PCa bone metastasis.

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“…In our previous study, we found that MMP-2/-9 play important roles in the invasion of cancer cells [3]. In gastric cancer, MMP-2/-9 are over-expressed and closely correlated with the metastasis of patients [24]. In a previous study, oxymatrine has observed to inhibit the invasion of gallbladder cancer cells via inhibiting the expression of MMP-2/-9 [18].…”

Section: Discussionmentioning

confidence: 91%

“…MMPs, especially MMP-2/-9, play important roles in breaking down the ECM [22,23]. Loss of the extracellular matrix (ECM) of blood or lymph vessels allows cancer cells to invade into the blood or lymphatic system and spread to other tissues and organs [3,24]. In our previous study, we found that MMP-2/-9 play important roles in the invasion of cancer cells [3].…”

Section: Discussionmentioning

confidence: 99%

Oxymatrine inhibits the migration and invasion of hepatocellular carcinoma cells by reducing the activity of MMP-2/-9 via regulating p38 signaling pathway

Chen¹,

Zhu²,

Ye³

et al. 2019

J. Cancer

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As one of the major alkaloid components in Sophoraflavescensait (kushen), oxymatrine has been used widely across the world in anti-inflammatory and anti-cancer therapies. However, the effect in the metastasis of hepatocellular carcinoma (HCC) and related mechanism(s) are still unclear. The present study aimed to investigate the anti-metastatic effect of oxymatrine on HCC cells. Oxymatrine could also inhibit the protein levels of MMP-2/-9 in a dose-dependent relationship. Moreover, oxymatrine reduces the activity of p38 signaling pathway via inhibiting the phosphorylation of p38. The inhibition effect of oxymatrine on the expression of MMP-2/-9 and the phosphorylated of p38 was also detected in vivo. Combined treatment with p38 signaling pathway inhibitor and oxymatrine may have a synergistic effect on MMP-2/-9 and invasion of HCC cells. Therefore, oxymatrine may have inhibited GBC invasiveness by reducing the expression of MMP-2/-9 via inhibiting the activity of p38 signaling pathway. As a potentially novel therapeutic drug, oxymatrine may play an important role in the treatment of HCC.

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Retracted: IFITM3 promotes hepatocellular carcinoma invasion and metastasis by regulating MMP9 through p38/MAPK signaling

Cited by 42 publications

References 31 publications

M2 Macrophages Promote HCC Cells Invasion and Migration via miR-149-5p/MMP9 Signaling

M2 Macrophages Promote HCC Cells Invasion and Migration via miR-149-5p/MMP9 Signaling

Ras and Wnt Interaction Contribute in Prostate Cancer Bone Metastasis

Oxymatrine inhibits the migration and invasion of hepatocellular carcinoma cells by reducing the activity of MMP-2/-9 via regulating p38 signaling pathway

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