Retracted: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo

Zhou, Qingchun; Yu, Jian; Zheng, Qingyou; Wu, Tao; Ji, Zhonghua; Zhuo, Yumin

doi:10.1002/2211-5463.12768

Cited by 11 publications

(19 citation statements)

References 32 publications

(54 reference statements)

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“…Kif14, Kif18b, Kif20b, Kif22, Kif23 and Kif2c were upregulated, which code microtubule-based motor proteins, involved in cell division, ciliogenesis, and vesicle transport. 23 We detected that eight genes of the C-C motif and C-X-C motif chemokine ligand family were upregulated, such as Ccl2 and Cxcl10. They are all potent recruiters of monocytes, T cells and dendritic cells to the sites of tissue damage or infection.…”

Section: Discussionmentioning

confidence: 92%

Gene Expression Profiling of the Liver and Lung in Mice After Exposure to ZnO Quantum Dots

Yang¹,

Li²,

Lin³

et al. 2020

IJN

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Introduction: ZnO quantum dots (QDs) have drawn much attention recently as they are Cd-free, low-cost, and have excellent optical properties. With the expanded production and application of ZnO nanoparticles, concerns about their potential toxicity have also been raised. Materials and Methods: We used RNA sequencing (RNA-seq) to analyze the global gene expression of liver and lung tissues after ZnO QDs treatment. Differentially expressed genes (DEGs) were screened, with a fold change >1.5 and padj <0.05. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed, and padj <0.05 was considered significantly enriched. The RNA-seq results were validated by quantitative real-time polymerase chain reaction (qRT-PCR). Results: A total of 47 and 218 genes were significantly differentially expressed in the liver and lung. Eight GO terms were enriched in the liver and lung, and retinol metabolism and the peroxisome proliferator-activated receptor (PPAR) signaling pathway were shared in different tissues. Discussion: According to DEGs and pathway enrichment analyses, inflammation might be induced in liver and lung tissues after intravenous injection of ZnO QDs. These findings will be helpful for future research and application of ZnO QDs.

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Section: Discussionmentioning

confidence: 92%

Gene Expression Profiling of the Liver and Lung in Mice After Exposure to ZnO Quantum Dots

Yang¹,

Li²,

Lin³

et al. 2020

IJN

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“…Lung cancer [28] Brain tumor [29] Breast cancer [30] Colorectal cancer [31] Bladder cancer [32] Kinesin-3 KIF1A, KIF1B KIF14 High…”

Section: Kifs In Cancer Biologymentioning

confidence: 99%

Kinesin superfamily proteins: roles in osteosarcoma

Song

Xue³

et al. 2021

Front Biosci (Landmark Ed)

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Background: Osteosarcoma is a common bone tumor with extremely high malignancy, occurring mostly in children and adolescents. At present, the survival rate of osteosarcomas has made progress in some aspects; however, this can only be regarded as a partial success because substantial progress has not been made in the last few decades. Object: The kinesin superfamily is a group of proteins that play regulatory roles in various metabolic processes and are closely related to tumor metastasis. Increasing evidence shows that kinesins play key roles in the occurrence and development of human cancer. Purpose: This review summarizes the roles of the kinesin superfamily proteins in osteosarcoma and related functions.Abbreviations: ATPase, adenosine triphosphatase; KIFs, kinesin superfamily protein.

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“…The proliferation and colony formation abilities of PC-3 and 22Rv1 cells transfected with siRNAs were examined using Cell Counting Kit-8 (CCK-8) reagents (Meilunbio, China) and colony formation assays, respectively. Detailed procedures are available in our previous report (Zhou et al, 2019). Each experiment was repeated three independent times.…”

Section: Cell Viability and Cell Colony Formation Assaymentioning

confidence: 99%

“…Primary antibodies against GAPDH (Proteintech), p62 (Santa Cruz), and MAP1LC3A (LC3, Novus) were used at a dilution of 1:1000. Detailed western blotting procedures were performed as described in our previous report (Zhou et al, 2019).…”

Section: Rna Extraction Reverse Transcription and Quantitative Real-time Polymerase Chain Reactionmentioning

confidence: 99%

A Six Autophagy-Related LncRNA Signature Associated with Clinical Prognosis in Prostate Cancer

Yuan

Huang

et al. 2021

Genetic Testing and Molecular Biomarkers

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Objective: Prostate cancer (PCa) is one of the leading causes of death by solid tumors in men, and autophagy plays an important role in tumor progression and treatment. This study was designed to construct and evaluate an autophagy-related prognosis model of PCa with long noncoding RNAs (lncRNAs). Materials and Methods: RNA sequencing data and clinical features were obtained from The Cancer Genome Atlas (TCGA) prostate adenocarcinoma (PRAD) dataset. These data were analyzed by Pearson correlation and Lasso regression to enrich for six autophagy-related prognostic lncRNAs that were used to build a progressionfree interval (PFI) prognostic model. In addition, survival and receiver operating characteristic (ROC) curve analyses were performed to evaluate the PFI's prognostic effect. Moreover, we used a nomogram analysis combined with other clinical features to improve its accuracy. Finally, we verified the biological function of LINC00342 using cell-based assays. Results: Six differentially expressed autophagy-related lncRNAs (LINC00342, AC092171.4, PCAT7, AC048341.2, FGF14-AS2, and AC005180.2) were identified between PCa and adjacent noncancerous tissues from the TCGA-PRAD dataset. A novel risk score model was established based on these six autophagy-related lncRNAs. PCa patients were then stratified into high-or low-risk groups in terms of their PFI; and the area under the ROC curve (AUC) determined to be significant. Moreover, we developed a nomogram with other clinical features that could be used for clinical decision-making. Lastly, we verified the oncogenic role of LINC00342 in promoting autophagy. Conclusions: We developed a novel six autophagy-related lncRNA signature for prediction of PFI in PCa. These lncRNAs may help establish individualized biomarkers and therapeutic targets for patients with PCa. Moreover, we also found an oncogenic role for LINC00342 in autophagy in PCa.

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Retracted: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo

Abstract: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo

Cited by 11 publications

References 32 publications

<p>Gene Expression Profiling of the Liver and Lung in Mice After Exposure to ZnO Quantum Dots</p>

<p>Gene Expression Profiling of the Liver and Lung in Mice After Exposure to ZnO Quantum Dots</p>

Kinesin superfamily proteins: roles in osteosarcoma

A Six Autophagy-Related LncRNA Signature Associated with Clinical Prognosis in Prostate Cancer

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