Retracted: Fast and efficient electrospinning of chitosan‐Poly(ethylene oxide) nanofibers as potential wound dressing agents for tissue engineering

Abstract

In this work, nanofibers of chitosan/poly (ethylene oxide) (PEO) with an average fiber diameter from a few microns down to about 30 nm and a narrow size distribution were fabricated by a fast electrospinning process using a handheld electrospinning device. It was found that the matrix with a formulation of chitosan/PEO ratio of 90/10 (w/w) and 0.3% Triton V R X-100 retained excellent integrity of the fibrous structure in 0.5M acetic acid solution. The characterization of nanofibrous structure by scanning electron microscope (SEM) imaging showed the homogeneity of nanofibrous structure without consid-erable bead-like structures. The excellent electrospinnability of the current formulation represents electrospinning of natural biopolymer chitosan as a useful process in various biomedical applications, especially as potential wound dressing agents. Nonwoven mats and polymer solutions with composition chitosan/PEO ratio of 90/10 and 60/40 showed excellent antibacterial activity against E. coli and P. aeruginosa. V C 2011 Wiley Periodicals, Inc. J Appl Polym Sci 000: 000-000, 2011

Antibacterial wound dressing from chitosan/polyethylene oxide nanofibers mats embedded with silver nanoparticles

“…PEO fibers exhibit great interest for biomedical devices contacting with living organisms. 20 In order to enhance the antibacterial properties of chitosan-based nanofibers, antimicrobial agents have been introduced into the fibers. For example, Dilamian et al 15 prepared chitosan/PEO nanofiber incorporating poly(hexamethylene biguanide) hydrochloride.…”

“…[17][18][19][20] In the blends, the fiber forming ability is improved by adjusting the interaction between polymer molecules. PEO is a water soluble polymer with good biocompatibility, low toxicity, and it is quite feasible and versatile for electrospinning.…”

Composite chitosan/poly(ethylene oxide) electrospun nanofibrous mats as novel wound dressing matrixes for the controlled release of drugs

“…Because of its good biocompatibility and low toxicity, PEO has attracted increasing interest for its applications in biomedical fields. As a polymer well‐suited for fiber formation in many solvents, especially water, its feasibility and versatility for electrospinning have been widely documented …”

Design, construction and performance of a portable handheld electrohydrodynamic multi-needle spray gun for biomedical applications

“…The pharmaceutical, cosmetic and food industries are showing an increasing interest in advanced techniques that produce multifunctional solid and encapsulated particles and fibers to engineer and commercialize efficient and cost-effective products, such as wound dressing patches [1], drug delivery systems [2], scaffolds [3], long lasting perfumes [4] and advanced food and confectionery products [5,6]. An ideal commercial product must be non-toxic, biocompatible, mechanically strong, simple to administer and easy to fabricate and sterilize [7].…”