<i>Retracted</i>: Circular RNA ACR relieves high glucose‐aroused RSC96 cell apoptosis and autophagy via declining microRNA‐145‐3p

doi:10.1002/jcb.29568

Cited by 32 publications

(17 citation statements)

References 52 publications

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“…The PI3K/AKT/mTOR pathway has also been revealed to be closely associated with autophagy ( 24 , 25 ). In addition, Liu et al ( 26 ) demonstrated that the PI3K/AKT signaling pathway was inhibited in a hyperglycemic environment, Autophagy-related circular RNA can attenuate autophagy and ROS production in Schwann cells subjected to hyperglycemia by promoting the activation of the PI3K/AKT/mTOR pathway ( 27 ).…”

Section: Introductionmentioning

confidence: 99%

Selenium attenuates ischemia/reperfusion injury‑induced damage to the blood‑brain barrier in hyperglycemia through PI3K/AKT/mTOR pathway‑mediated autophagy inhibition

Yang

et al. 2021

Int J Mol Med

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Ischemic stroke is a leading cause of mortality and disability. diabetes mellitus, characterized by hyperglycemia, is a common concomitant disease of ischemic stroke, which is associated with autophagy dysfunction and blood-brain barrier (BBB) damage following cerebral ischemia/reperfusion (I/R) injury. At present, there is no effective treatment strategy for the disease. The purpose of the present study was to explore the molecular mechanisms underlying the protective effects of selenium on the BBB following I/R injury in hyperglycemic rats. Middle cerebral artery occlusion was performed in diabetic Sprague-dawley rats. Treatment with selenium and the autophagy inhibitor 3-methyladenine significantly reduced cerebral infarct volume, brain water content and Evans blue leakage, while increasing the expression of tight junction (TJ) proteins and decreasing that of autophagy-related proteins (P<0.05). In addition, selenium increased the phosphorylation levels of PI3K, AKT and mTOR (P<0.05). A mouse bEnd.3 brain microvascular endothelial cell line was co-cultured in vitro with an MA-h mouse astrocyte-hippocampal cell line to simulate the BBB. The cells were then subjected to hyperglycemia, followed by oxygen-glucose deprivation for 1 h and reoxygenation for 24 h. It was revealed that selenium increased TJ protein levels, reduced BBB permeability, decreased autophagy levels and enhanced the expression of phosphorylated (p)-AKT/AKT and p-mTOR/mTOR proteins (P<0.05). Treatment with wortmannin (an inhibitor of PI3K) significantly prevented the beneficial effects of selenium on the BBB, whereas insulin-like growth factor 1 (a PI3K activator) mimicked the effects of selenium. In conclusion, the present findings indicated that selenium can inhibit autophagy by regulating the PI3K/AKT/mTOR signaling pathway, significantly preventing BBB damage following cerebral I/R injury in hyperglycemic conditions.

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Section: Introductionmentioning

confidence: 99%

Selenium attenuates ischemia/reperfusion injury‑induced damage to the blood‑brain barrier in hyperglycemia through PI3K/AKT/mTOR pathway‑mediated autophagy inhibition

Yang

et al. 2021

Int J Mol Med

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“…Liu et al discovered that the expression of circACR was reduced in HG-irritated rat Schwann RSC96 cells, which relieved the oxidative stress caused by HG via declining miR-145-3p and promoting PI3K/AKT/mTOR pathway activation [ 95 ].…”

Section: Regulatory Role Of Circrnas In Oxidative Stress: Implicatmentioning

confidence: 99%

Emerging Clues of Regulatory Roles of Circular RNAs through Modulating Oxidative Stress: Focus on Neurological and Vascular Diseases

Jiang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Circular RNAs (circRNAs) are novel noncoding RNAs that play regulatory roles in gene expression. Dysregulation of circRNAs is associated with the development and progression of several diseases, such as diabetes mellitus, nervous system diseases, cardiovascular diseases, and cancer. CircRNAs functionally participate in cell physiological activities through various molecular mechanisms. However, these molecular mechanisms are unclear. Oxidative stress is an essential factor in the pathogenesis of various diseases, including neurological diseases. Emerging roles of circRNAs have been identified in different systems in response to oxidative stress. In this review, we summarize the current understanding of circRNA biogenesis, properties, expression profiles, and the clues indicating the regulatory roles of circRNAs through oxidative stress in various systems, especially the nervous system.

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“…High glucose (HG) induces the downregulation of circACR in RSC96 cells. CircACR may downregulate the expression of miR-145-3p and promote the activation of the PI3K/AKT/mTOR pathway to alleviate HG-induced apoptosis, autophagy, and ROS generation in RSC96 cells ( Liu et al, 2019 ). Heat stress may enhance the generation of oxidative stress ( Slimen et al, 2014 ).…”

Section: Research Progress On Circrnas and Oxidative-stress‒related Diseasesmentioning

confidence: 99%

Circular RNAs in the Regulation of Oxidative Stress

et al. 2021

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Oxidative stress caused by an imbalance between the production and elimination of reactive metabolites and free radicals can lead to the development of a variety of diseases. Over the past years, with the development of science and technology, circular RNA (circRNA) has been found to be closely associated with oxidative stress, which plays an important role in the process of oxidative stress. Currently, the understanding of circRNAs in the mechanism of oxidative stress is limited. In this review, we described the relationship between oxidative stress and circRNAs, the circRNAs related to oxidative stress, and the role of circRNAs in promoting or inhibiting the occurrence and development of diseases associated with the oxidative stress system.

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Retracted: Circular RNA ACR relieves high glucose‐aroused RSC96 cell apoptosis and autophagy via declining microRNA‐145‐3p

Cited by 32 publications

References 52 publications

Selenium attenuates ischemia/reperfusion injury‑induced damage to the blood‑brain barrier in hyperglycemia through PI3K/AKT/mTOR pathway‑mediated autophagy inhibition

Selenium attenuates ischemia/reperfusion injury‑induced damage to the blood‑brain barrier in hyperglycemia through PI3K/AKT/mTOR pathway‑mediated autophagy inhibition

Emerging Clues of Regulatory Roles of Circular RNAs through Modulating Oxidative Stress: Focus on Neurological and Vascular Diseases

Circular RNAs in the Regulation of Oxidative Stress

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