<i>Retracted:</i>A Biomimetic Emu Oil-Blended Electrospun Nanofibrous Mat for Maintaining Stemness of Adipose Tissue-Derived Stem Cells

Jalilzadeh-Tabrizi, Sepideh; Pilehvar-Soltanahmadi, Younes; Alipour, Shahriar; Dadashpour, Mehdi; Nejati-Koshki, Kazem

doi:10.1089/bio.2017.0056

Cited by 8 publications

(3 citation statements)

References 41 publications

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“…In recent years, advances in nanomaterials‐based drug delivery carriers have paved the way for overcoming these obstacles (Deldar, Zarghami, Pilehvar‐Soltanahmadi, Dadashpour, & Zarghami, ; Farajzadeh et al., ; Montazeri et al., ). The main advantages of nanocarriers for anticancer drugs include improved therapeutic effect, extended half‐life in the bloodstream, increased water solubility, improved stability, selective delivery to specific site, and decreased hepatotoxicity (Firouzi‐Amandi et al., ; Jalilzadeh‐Tabrizi et al., ; Nejati‐Koshki, Mortazavi, Pilehvar‐Soltanahmadi, Sheoran, & Zarghami, ; Zamani, Pilehvar‐Soltanahmadi, Alizadeh, & Zarghami, ). Despite these benefits, each nanocarrier has some drawbacks, which are discussed below.…”

Section: ‐Aag‐loaded Nanocarriersmentioning

confidence: 99%

Spotlight on 17‐AAG as an Hsp90 inhibitor for molecular targeted cancer treatment

et al. 2019

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Hsp90 is a ubiquitous chaperone with important roles in the organization and maturation of client proteins that are involved in the progression and survival of cancer cells. Multiple oncogenic pathways can be affected by inhibition of Hsp90 function through degradation of its client proteins. That makes Hsp90 a therapeutic target for cancer treatment. 17‐allylamino‐17‐demethoxy‐geldanamycin (17‐AAG) is a potent Hsp90 inhibitor that binds to Hsp90 and inhibits its chaperoning function, which results in the degradation of Hsp90's client proteins. There have been several preclinical studies of 17‐AAG as a single agent or in combination with other anticancer agents for a wide range of human cancers. Data from various phases of clinical trials show that 17‐AAG can be given safely at biologically active dosages with mild toxicity. Even though 17‐AAG has suitable pharmacological potency, its low water solubility and high hepatotoxicity could significantly restrict its clinical use. Nanomaterials‐based drug delivery carriers may overcome these drawbacks. In this paper, we review preclinical and clinical research on 17‐AAG as a single agent and in combination with other anticancer agents. In addition, we highlight the potential of using nanocarriers and nanocombination therapy to improve therapeutic effects of 17‐AAG.

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Section: ‐Aag‐loaded Nanocarriersmentioning

confidence: 99%

Spotlight on 17‐AAG as an Hsp90 inhibitor for molecular targeted cancer treatment

et al. 2019

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“…Jalilzadeh-Tabrizi et al. claimed the Emu-oil in PCL/PEG nanofibers could improve the ADSCs cell adhesion [68]. Zarghami et al.…”

Section: Resultsmentioning

confidence: 99%

“…It has been reported that oils enhanced cell attachment because of their long fatty acid [58]. Jalilzadeh-Tabrizi et al claimed the Emu-oil in PCL/PEG nanofibers could improve the ADSCs cell adhesion [68]. Zarghami et al observed the proper morphology of fibroblast cell attachment on PEO/Chitosan/PCL/Olive oil [24].…”

Section: Biological Propertiesmentioning

confidence: 99%

Antibacterial and biological properties of coconut oil loaded poly(ε-caprolactone)/gelatin electrospun membranes

Mohamadi

Hivechi

Bahrami

et al. 2021

Journal of Industrial Textiles

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Coconut oil (CO) is a naturally derived bio-oil which exhibits specific characteristics such as biocompatibility and antibacterial activity. In this work, the biological properties of poly(caprolactone)/gelatin (PCL/Gel) nanofibers are improved using CO encapsulation. This bio-oil was added to the PCL/Gel polymer solution with different concentrations (5–40%). Nanofibers were crosslinked using glutaraldehyde vapor. Different types of characterization techniques such as SEM, FTIR, DSC, tensile measurements, water contact angle, and water vapor permeability were used to study the chemical, physical, thermal, and morphological properties of resultant nanofibers. Results showed an average diameter of 300–370 nm for as-spun nanofibers, which increased to 360–470 nm after the crosslinking reaction. The presence of CO was confirmed using FTIR and DSC experiments. Moreover, results indicated that the presence of CO increases the hydrophilicity and water vapor permeability of nanofibers, which are desirable for their final application. Biological tests, such as antibacterial activity, cell viability, and cell morphology tests were performed to evaluate the possible application of the produced nanofibers for wound healing applications. Results indicated that the crosslinked PCL/Gel nanofibers containing 20% CO exhibited the highest cell compatibility and antibacterial activity against gram-positive (S. aureus) and gram-negative ( E. coli) bacteria.

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A glimpse into molecular mechanisms of embryonic stem cells pluripotency: Current status and future perspective

Maroufi

Hasegawa

Vahedian

et al. 2020

Journal Cellular Physiology

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Embryonic stem cells have potential differentiation ability into a large variety of cell lineages and proved to be an effective therapeutic modality. However, prolonged in vitro and ex-vivo expansions impair embryonic stem cells multipotentiality, and thereby limit their clinical application. In the past few years, research collected attempts to explore new insights into the molecular mechanisms participate in the stemness capacity of embryonic stem cells. Along with these comments, modalities and strategies with the potential to maintain embryonic stem cells multipotentiality are of great interest. In this review, the authors attempted to discuss the pathways participating in the preservation of embryonic stem cells multipotentiality and emphasized the novel strategies that help to harness regenerative potential.

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Retracted:A Biomimetic Emu Oil-Blended Electrospun Nanofibrous Mat for Maintaining Stemness of Adipose Tissue-Derived Stem Cells

Cited by 8 publications

References 41 publications

Spotlight on 17‐AAG as an Hsp90 inhibitor for molecular targeted cancer treatment

Spotlight on 17‐AAG as an Hsp90 inhibitor for molecular targeted cancer treatment

Antibacterial and biological properties of coconut oil loaded poly(ε-caprolactone)/gelatin electrospun membranes

A glimpse into molecular mechanisms of embryonic stem cells pluripotency: Current status and future perspective

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