<i>Reg3G</i>gene expression in regenerating skeletal muscle and corresponding nerve

Klasan, Gordana Starčević; Ivanac, Danijel; Jurišić‐Eržen, Dubravka; Picard, Anne; Takasawa, Shin; Peharec, Stanislav; Arbanas, Juraj; Girotto, Dean; Jerković, Romana

doi:10.1002/mus.23877

Cited by 13 publications

(10 citation statements)

References 23 publications

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“…These are associated with several important traits. For example, REG3G, IER3, SGMS2, and DKK2 [52][53][54][55] are involved in skeletal development, TNXB [56] in muscle growth, CH25H, DRG1 [57,58] in digestive secretion, and NGLY [59] in vision. The genes OXSM and NGLY are also located in regions affected by both introgression and artificial selection.…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Analysis Reveals Human-Mediated Introgression from Western Pigs to Indigenous Chinese Breeds

Wang

Liu

Chen

et al. 2020

Genes

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Genetic variations introduced via introgression from Western to Chinese pigs have contributed to the performance of Chinese breeds in traits such as growth rate and feed conversion efficiency. However, little is known about the underlying genomic changes that occurred during introgression and the types of traits affected by introgression. To address these questions, 525 animals were characterized using an SNP array to detect genomic regions that had been introgressed from European to indigenous Chinese breeds. The functions of genes located in introgressed regions were also investigated. Our data show that five out of six indigenous Chinese breeds show evidence of introgression from Western pigs, and eight introgressed genome regions are shared by five of the Chinese breeds. A region located on chr13: 12.8-13.1 M was affected by both introgression and artificial selection, and this region contains the glucose absorption related gene, OXSM, and the sensory related gene, NGLY. The results provide a foundation for understanding introgression from Western to indigenous Chinese pigs.

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Section: Discussionmentioning

confidence: 99%

Genome-Wide Analysis Reveals Human-Mediated Introgression from Western Pigs to Indigenous Chinese Breeds

Wang

Liu

Chen

et al. 2020

Genes

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“…These factors included Reg3g , Krt16 , Serpinb2, S100a8, Rarres2, Serpine1, Actn1, Icam1, Lamc2 , Fos , Mt2A , Niacr1 , Fam110c, Egr1, Nov, and Trem1 66. All were upregulated with suturing and suppressed following suture removal to a greater degree than VegfA .…”

Section: Discussionmentioning

confidence: 99%

Factors regulating capillary remodeling in a reversible model of inflammatory corneal angiogenesis

Mukwaya

Peebo

Xeroudaki

et al. 2016

Sci Rep

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Newly formed microcapillary networks arising in adult organisms by angiogenic and inflammatory stimuli contribute to pathologies such as corneal and retinal blindness, tumor growth, and metastasis. Therapeutic inhibition of pathologic angiogenesis has focused on targeting the VEGF pathway, while comparatively little attention has been given to remodeling of the new microcapillaries into a stabilized, functional, and persistent vascular network. Here, we used a novel reversible model of inflammatory angiogenesis in the rat cornea to investigate endogenous factors rapidly invoked to remodel, normalize and regress microcapillaries as part of the natural response to regain corneal avascularity. Rapid reversal of an inflammatory angiogenic stimulus suppressed granulocytic activity, enhanced recruitment of remodelling macrophages, induced capillary intussusception, and enriched pathways and processes involving immune cells, chemokines, morphogenesis, axonal guidance, and cell motility, adhesion, and cytoskeletal functions. Whole transcriptome gene expression analysis revealed suppression of numerous inflammatory and angiogenic factors and enhancement of endogenous inhibitors. Many of the identified genes function independently of VEGF and represent potentially new targets for molecular control of the critical process of microvascular remodeling and regression in the cornea.

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“…; Klasan et al. ). However, almost nothing is known about cardiac Reg3 γ gene expression, although increased Reg3 γ expression has been repeatedly identified in cardiac gene expression profiling screens (Rysä et al.…”

Section: Discussionmentioning

confidence: 97%

“…), skeletal muscle (Klasan et al. ) as well as in central and peripheral nervous system (Namikawa et al. , ; Ampo et al.…”

Section: Discussionmentioning

confidence: 99%

“…The secretory protein Reg3c (also known as PAP III) is expressed in several tissues, and its expression is induced in various injuries and inflammatory conditions in gastrointestinal tract (Iovanna et al 1992;Ogawa et al 2003), skeletal muscle (Klasan et al 2014) as well as in central and peripheral nervous system (Namikawa et al 2005(Namikawa et al , 2006Ampo et al 2009;Kawahara et al 2011;Klasan et al 2014). However, almost nothing is known about cardiac Reg3c gene expression, although increased Reg3c expression has been repeatedly identified in cardiac gene expression profiling screens (Rys€ a et al 2005;Tenhunen et al 2006a;Watanabe et al 2008;Liu et al 2009).…”

Section: Discussionmentioning

confidence: 99%

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Mitogen‐activated protein kinase p38 target regenerating islet‐derived 3γ expression is upregulated in cardiac inflammatory response in the rat heart

Säkkinen

Aro

Kaikkonen

et al. 2016

Physiological Reports

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Regenerating islet‐derived 3γ (Reg3γ) is a multifunctional protein, associated with various tissue injuries and inflammatory states. Since chronic inflammation is characteristics also for heart failure, the aim of this study was to characterize Reg3γ expression in cardiac inflammatory conditions. Reg3γ expression was studied in experimental rat models of myocardial infarction (MI) and pressure overload in vivo. For cell culture studies neonatal rat cardiac myocytes (NRCMs) were used. In addition, adenovirus‐mediated gene transfer of upstream mitogen‐activated protein kinase (MAPK) kinase 3b and p38α MAPK in vivo and in vitro was performed. Reg3γ mRNA (12.8‐fold, P < 0.01) and protein (5.8‐fold, P < 0.001) levels were upregulated during the postinfarction remodeling at day 1 after MI, and angiotensin II (Ang II) markedly increased Reg3γ mRNA levels from 6 h to 2 weeks. Immunohistochemistry revealed that the Ang II‐induced expression of Reg3γ was localized into the cardiac fibroblasts and myofibroblasts of the proliferating connective tissue in the heart. Stretching and treatments with endothelin‐1, lipopolysaccharide (LPS), and fibroblast growth factor‐1 increased Reg3γ mRNA levels in NRCMs. SB203580, a selective p38 MAPK inhibitor, markedly attenuated LPS and mechanical stretch‐induced upregulation of Reg3γ gene expression. Moreover, combined overexpression of MKK3bE and WT p38α increased Reg3γ gene expression in cultured cardiomyocytes in vitro and in the rat heart in vivo. Our study shows that cardiac stress activates Reg3γ expression and p38 MAPK is an upstream regulator of Reg3γ gene expression in heart. Altogether our data suggest Reg3γ is associated with cardiac inflammatory signaling.

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Reg3Ggene expression in regenerating skeletal muscle and corresponding nerve

Abstract: The results suggest that the Reg3G gene plays a major role in communication between injured axons and muscle and may play a significant role in skeletal muscle and peripheral nerve regeneration.

Cited by 13 publications

References 23 publications

Genome-Wide Analysis Reveals Human-Mediated Introgression from Western Pigs to Indigenous Chinese Breeds

Genome-Wide Analysis Reveals Human-Mediated Introgression from Western Pigs to Indigenous Chinese Breeds

Factors regulating capillary remodeling in a reversible model of inflammatory corneal angiogenesis

Mitogen‐activated protein kinase p38 target regenerating islet‐derived 3γ expression is upregulated in cardiac inflammatory response in the rat heart

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