I. Red Blood Cell Hemolysis by Photosensitizing Compounds

Kahn, Guinter; Fleischaker, Barbara

doi:10.1111/1523-1747.ep12260639

Cited by 77 publications

(28 citation statements)

References 11 publications

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“…Four of 10 volunteers were found to be more sensitive to UV A light after a dose of nalidixic acid (Rosen & Swan beck 1981), and in mouse (Keane et al 1984) and yeast (Kahn & F1eishaker 1971) studies, phototoxicity was reported with this drug. More than 30 cases of bullous eruptions after sun exposure have been reported in association with nalidixic acid (Brauner 1975).…”

Section: Photosensitivitymentioning

confidence: 99%

Clinical Features and Management of Adverse Effects of Quinolone Antibacterials

Paton

Reeves

1991

Drug Safety

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The quinolone antibacterials are proving very useful in the management of infection, notably for the treatment of Gram-negative bacteria. With the increasing use of these drugs, adverse effects are being recognised more often and careful documentation is still required. In general, the quinolones are of low toxicity. Gastrointestinal adverse effects are the most common, and are usually mild; indeed, all adverse events are generally mild and resolve on withdrawal of the offending drug. Certain precautions and contraindications are apparent. Because drug-induced arthropathies occur in juvenile animals, quinolones should not be administered to pregnant or lactating women or to growing children, unless the clinical benefit outweighs the risk. Caution should also be observed in patients with previous epilepsy or severe cerebral arteriosclerosis. Neurological effects may require the use of appropriate neuro- and psychoactive drugs, as well as the withdrawal of the precipitating agent. Hypersensitivity reactions to a fluoroquinolone may require the use of antihistamines, and in some cases topical or systemic steroids, and may well preclude future use of a fluoroquinolone. Dose adjustments may be necessary in patients with reduced renal function, when the measurement of serum concentrations may be desirable. Interstitial nephritis, haematuria and acute renal failure are rare effects of quinolone therapy which will require appropriate management including withdrawal of the precipitating drug. Interactions with theophylline and warfarin are of clinical significance, and may require plasma concentration monitoring and adjustment of dosage.

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Section: Photosensitivitymentioning

confidence: 99%

Clinical Features and Management of Adverse Effects of Quinolone Antibacterials

Paton

Reeves

1991

Drug Safety

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“…In humans 4 out of 39 subjects were affected (Martin el al., 1973). W e have evaluated the photosensitized lysis of R B C (Kahn and Fleischaker, 1971) t o determine if this method would reliably predict the phototoxicity Of these antimalarial compounds. We find this system does reflect the phototoxicity of these materials as measured in the mouse test system, and provides *To whom correspondence should be addressed.…”

Section: Introductionmentioning

confidence: 99%

Photosensitized Lysis of Red Blood Cells by Phototoxic Antimalarial Compounds

Epling

Sibley

1987

Photochem & Photobiology

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A family of 12 phototoxic quinolinemethanol antimalarials and three other non-phototoxic clinically used compounds were irradiated in the presence of red blood cells to determine if the resulting hemolysis would be a reliable predictor of phototoxicity. The most phototoxic compounds from in vivo tests were also the most phototoxic in this study. Quinine caused little RBC lysis, paralleling its non-phototoxicity in humans. The quinolinemethanol-induced photohemolysis occurs both in the presence and absence of oxygen. Enriching the RBC with BHA and cholesterol was particularly effective at protecting the cells from photohemolysis. Other compounds offered some measure of protection, while superoxide dismutase and sodium azide, among others, afforded no protection.

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“…Thymine, thymidine and 5FU solutions in tissue culture carrels were stirred and radiated 24 h under a FS-40 Westinghouse sunlamp allowing wavelengths 290-370 nm of about 101 erg/cm'-/sec energy to test the photostability of the compounds [5].…”

Section: Methodsmentioning

confidence: 99%

UV Protective Effects of 5-FIuorouracil and Thymidine

Kahn¹,

Curry²,

Dustin³

1973

Dermatology

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We confirm the previously claimed protection by 5-fluorouracil against ultraviolet radiation on the skin. We conclude that such protection is the result of absorption of erythema producing light (wavelengths less than 320 nm). Previously reported absorption of 5-fluorouracil in the 260– to 280-nm range was determined at concentrations several thousandfold less than those tested by us and used clinically. Our absorption studies, carried out in the clinical concentration range, show that 5-fluorouracil absorbs light even into long wave ultraviolet (greater than 320 nm). Such absorption occurs to a lesser extent with thymidine and accounts for the greater clinical protection achieved with 5-fiuorouracil.

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I. Red Blood Cell Hemolysis by Photosensitizing Compounds

Cited by 77 publications

References 11 publications

Clinical Features and Management of Adverse Effects of Quinolone Antibacterials

Clinical Features and Management of Adverse Effects of Quinolone Antibacterials

Photosensitized Lysis of Red Blood Cells by Phototoxic Antimalarial Compounds

UV Protective Effects of 5-FIuorouracil and Thymidine

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