2003
DOI: 10.1073/pnas.1031853100
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Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb -deficient mice

Abstract: Retinoblastoma (Rb)-deficient embryos show severe defects in neurogenesis, erythropoiesis, and lens development and die at embryonic day 14.5. Our recent results demonstrated a drastic disorganization of the labyrinth layer in the placenta of Rbdeficient embryos, accompanied by reduced placental transport function. When these Rb ؊/؊ embryos were supplied with a wildtype placenta by using either tetraploid aggregation or genetic approaches, animals survived until birth. Here we analyze the role of extraembryoni… Show more

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Cited by 119 publications
(112 citation statements)
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“…We then analysed the percentage of dead embryos for each genotype between E10 and E14.5 (Figure 1c). Death of the Rb À/À Abl þ / þ embryos occurred from E12 through E14.5, consistent with previous reports (Clarke et al, 1992;Jacks et al, 1992;Lee et al, 1992;de Bruin et al, 2003;Wu et al, 2003). We found a statistically significant reduction (Po0.05) of death with the Rb À/À Abl þ /À embryos when compared to Rb À/À Abl þ / þ embryos ( Figure 1c).…”
Section: Resultssupporting
confidence: 91%
See 1 more Smart Citation
“…We then analysed the percentage of dead embryos for each genotype between E10 and E14.5 (Figure 1c). Death of the Rb À/À Abl þ / þ embryos occurred from E12 through E14.5, consistent with previous reports (Clarke et al, 1992;Jacks et al, 1992;Lee et al, 1992;de Bruin et al, 2003;Wu et al, 2003). We found a statistically significant reduction (Po0.05) of death with the Rb À/À Abl þ /À embryos when compared to Rb À/À Abl þ / þ embryos ( Figure 1c).…”
Section: Resultssupporting
confidence: 91%
“…In mice, the constitutive knockout of Rb causes embryonic lethality resulting from defects in placental function (Clarke et al, 1992;Jacks et al, 1992;Lee et al, 1992;de Bruin et al, 2003;Wu et al, 2003). The Rb-knockout embryos exhibit inappropriate cell cycle entry and massive apoptosis in the developing central nervous system (CNS), peripheral nervous system, lens, liver and muscles (Clarke et al, 1992;Jacks et al, 1992;Lee et al, 1992).…”
Section: Introductionmentioning
confidence: 99%
“…This possibility is supported by several reports of de novo DNA synthesis after neuronal injury in tissue cultures or mutant mice (Sanes and Okun, 1972;Al-Ubaidi et al, 1992;Smith et al, 2000;Klein et al, 2002;de Bruin et al, 2003). Furthermore, neurofibrillary tangles in specimens from Alzheimer's disease patients are labeled by an antibody for mitotic phosphoepitopes (Vincent et al, 1996).…”
Section: Introductionmentioning
confidence: 78%
“…In particular, although ectopic proliferation continued in the CNS, apoptosis was suppressed, and erythrocyte developmental delays were almost completely suppressed. In contrast, both ectopic proliferation and apoptosis in the lens were unaffected, and the skeletal muscle defect was not restored (de Bruin et al, 2003b;Wu et al, 2003). In light of these findings, the suppression effects of the RbÀ/À phenotype by loss of the activating E2Fs will need to be revisited: does the removal of E2F 1 or 3 reduce CNS apoptosis through an indirect effect of restoring placental development?…”
Section: Studies Of Rb Family Proteins In Micementioning
confidence: 99%