(R,S)-2,2′-(Ethane-1,2-diyldiiminio)dibutan-1-ol dinitrate

Abstract

Key indicatorsSingle-crystal X-ray study T = 113 K Mean (C-C) = 0.003 Å R factor = 0.060 wR factor = 0.158 Data-to-parameter ratio = 17.9For details of how these key indicators were automatically derived from the article, see

(2R,2′S)-2,2′-(Ethane-1,2-diyldiiminio)bis(butane-2,1-diyl) disulfate dihydrate

“…1). Bond lengths and angles are normal (Allen et al, 1987) and similar to those found in the neutral (R,S)molecule (Bai, Zhang, Qin et al, 2006), in (R,S)-ethambutol dinitrate (Bai, Zhang, Simpson et al, 2006) and in comparable aminoethyl sulfate compounds (Post, 1978;Munns et al, 1981). The O1-C1-C2-N1 torsion angle of 63.7 (2) indicates a gauche conformation, as found in similar aminoethylsulfate derivatives (Post, 1978;Munns et al, 1981).…”

Reducing the Hygroscopicity of the Anti-Tuberculosis Drug (S,S)-Ethambutol Using Multicomponent Crystal Forms

“…In order to overcome the undesirable effects of ( S , S )-EDH, an extensive amount of studies have been emerged in the last few years, many of them dealing with the development of multicomponent crystal forms of this drug. − Recently, Nangia et al have been prepared and characterized five salts (sulfate, dimesylate, ditosylate, dibesylate, and fumarate) and two ionic liquids (dibenzoate and adipate), but all of them were found to be hygroscopic . For this reason, herein we report a screen of ETB with a series of carboxylic/dicarboxylic acids, trichloroacetic, maleic, oxalic, and terephthalic acids.…”