(R)- and (S)-2,2′-Bis(diphenylphosphino)-6,6′-dimethoxy-1,1′-biphenyl

Synthesis of atropisomeric chiral MeOBIPHEP analogues via Pd-catalyzed P–C coupling — applications to asymmetric Rh-catalyzed C–C bond formations in water

“…In this field, chiral ligands, and more specifically atropisomeric ligands since the discovery of atropisomeric binaphthyl BINAP, have proven to be outstanding chiral inducers [2,3]. The main strategies for their synthesis involved a Grignard addition to a phosphane intermediate [4], a Pd-or Ni-catalyzed phosphorus-carbon bond formation starting from bistriflate derivatives [5,6] or a chiral phosphonate and an aryl Grignard reagent [7,8]. These three strategies have been highly successful and have led to the development of an important number of new ligands.…”