<i>Pseudomonas aeruginosa</i>Keratitis: Outcomes and Response to Corticosteroid Treatment

Sy, Aileen; Srinivasan, Muthiah; Mascarenhas, Jeena; Lalitha, Prajna; Rajaraman, Revathi; Ravindran, Meenakshi; Oldenburg, Catherine E.; Ray, Kathryn J.; Glidden, David V.; Zegans, Michael E.; McLeod, Stephen D.; Lietman, Thomas M.; Acharya, Nisha R.

doi:10.1167/iovs.11-7840

Cited by 90 publications

(65 citation statements)

References 17 publications

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“…Clinical presentation of bacterial keratitis include acute pain, redness, photophobia and corneal ulceration [179]. Pseudomonas ulcers are more severe at presentation than other bacterial ulcers and are often difficult to treat, resulting in worse visual outcome than other bacterial ulcers [56,183].…”

Section: Bacterial Keratitismentioning

confidence: 99%

Pathogenesis of microbial keratitis

Lakhundi

Siddiqui

Khan

2017

Microbial Pathogenesis

171

121

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Microbial keratitis is a sight-threatening ocular infection caused by bacteria, fungi, and protist pathogens. Epithelial defects and injuries are key predisposing factors making the eye susceptible to corneal pathogens. Among bacterial pathogens, the most common agents responsible for keratitis include Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumonia and Serratia species. Fungal agents of corneal infections include both filamentous as well as yeast, including Fusarium, Aspergillus, Phaeohyphomycetes, Curvularia, Paecilomyces, Scedosporium and Candida species, while in protists, Acanthamoeba spp. are responsible for causing ocular disease. Clinical features include redness, pain, tearing, blur vision and inflammation but symptoms vary depending on the causative agent. The underlying molecular mechanisms associated with microbial pathogenesis include virulence factors as well as the host factors that aid in the progression of keratitis, resulting in damage to the ocular tissue. The treatment therefore should focus not only on the elimination of the culprit but also on the neutralization of virulence factors to minimize the damage, in addition to repairing the damaged tissue. A complete understanding of the pathogenesis of microbial keratitis will lead to the rational development of therapeutic interventions. This is a timely review of our current understanding of the advances made in this field in a comprehensible manner. Coupled with the recently available genome sequence information and high throughput genomics technology, and the availability of innovative approaches, this will stimulate interest in this field.

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Section: Bacterial Keratitismentioning

confidence: 99%

Pathogenesis of microbial keratitis

Lakhundi

Siddiqui

Khan

2017

Microbial Pathogenesis

171

121

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“…7 P. aeruginosa is the most common cause of Gramnegative bacterial keratitis 29,71 with a more severe clinical course than other bacterial pathogens if left untreated. 72 The healthy eye is generally protected against P. aeruginosa infection. Although cultured corneal epithelial cells are easily invaded and killed by most clinical and laboratory isolates of P. aeruginosa, 19,73 extremely large inoculates of invasive and cytotoxic P. aeruginosa onto intact mouse or rat corneas in vivo results in rapid bacterial clearance from the ocular surface without pathology.…”

Section: Pattern Recognition Mechanisms Activated By Microbial Pathogmentioning

confidence: 99%

Pattern recognition receptors in microbial keratitis

Taube

Cendra

Elsahn

et al. 2015

Eye

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“…Most ophthalmologists recommend starting anti-microbial empirically before culture results are available [37][38][39]. A study from Japan showed better results when anti-microbial agents were selected based on culture results, stressing the impor-tance of culture results [40].…”

Section: Management Of P Aeruginosa Keratitismentioning

confidence: 99%

Management of Psuedomonas Keratitis: a review article

Alsaad¹

2017

int. arab. j antimicrob. agents

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Bacterial keratitis can lead to severe vision loss and corneal scarring, and possibly perforation. Early and appropriate management is a key factor in decreasing and preventing complication.Pubmed and Medline were searched for articles related to Pseudomonas keratitis between year 2000 and 2017 to get current guidelines about the management of Pseudomonas keratitis. These articles are reviewed in this article and information related to management is summarized.The most used agents to treat Pseudomonas are either aminoglycosides (usually gentamicin) fortified with a cephalosporin or mono therapy with a fluoroquinolones usually ciprofloxacin. In most areas, most strains of Pseudomonas were susceptible to ciprofloxacin. The role of topical steroids is discussed, as well as, available options for treatment of multidrug resistant Pseudomonas species.

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Pseudomonas aeruginosaKeratitis: Outcomes and Response to Corticosteroid Treatment

Cited by 90 publications

References 17 publications

Pathogenesis of microbial keratitis

Pathogenesis of microbial keratitis

Pattern recognition receptors in microbial keratitis

Management of Psuedomonas Keratitis: a review article

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