<i>Pseudomonas Aeruginosa</i>
            : Arsenal of Resistance Mechanisms, Decades of Changing Resistance Profiles, and Future Antimicrobial Therapies

Zowalaty, Mohammed E El; Thani, Asmaa A. Al; Webster, Thomas J.; Zowalaty, Ahmed E. El; Schweizer, Herbert P.; Nasrallah, Gheyath K.; Marei, Hany E.; Ashour, Hossam M.

doi:10.2217/fmb.15.48

Cited by 127 publications

(105 citation statements)

References 203 publications

(216 reference statements)

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“…1 24 anti biotics (El Zowalaty et al, 2015). The literature is rich in surveillance studies from all over the world reporting varying resistance rates among P. aeruginosa against different antimicrobial agent.…”

Section: Introductionmentioning

confidence: 99%

“…Geographical variations and differences in the resistance rates of P. aeruginosa usually correlate with the prescription patterns of antimicrobial agents prescribing habits, overuse of antimicrobial agents in different parts of the world, and the selective pressure of certain 1 24 anti biotics (El Zowalaty et al, 2015). The literature is rich in surveillance studies from all over the world reporting varying resistance rates among P. aeruginosa against different antimicrobial agent.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of Antipseudomonal Antibiotics and Mechanisms of Multidrug Resistance in Pseudomonas aeruginosa

Zowalaty

Gyetvai

2016

Polish Journal of Microbiology

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A b s t r a c tPseudomonas aeruginosa is a leading human pathogen that causes serious infections at various tissues and organs leading to life threatening health problems and possible deadly outcomes. Resistance patterns vary widely whether it is from hospitals or community acquired infections. Reporting resistance profiles to a certain antibiotics provide valuable information in a given setting, but may be extrapolated outside the sampling location. In the present study, P. aeruginosa isolates were screened to determine their susceptibilities against antipseudomonal antimicrobial agents and possible existing mechanisms of resistance were determined. Eighty-six isolates of P. aeruginosa were recovered. Isolates representing different resistance profiles were screened for the existence of three different resistance mechanisms including drug inactivation due to metallo-β-lactamases, drug impermeability by outer membrane proteins and drug efflux. All tested isolates showed uniform susceptibility (100%, n = 86/86) to piperacillin, meropenem, amikacin, and polymyxin B. A single isolate was found to be imipenem resistant (99%, n = 85/86). The possible mechanisms of resistance of P. aeruginosa to imipenem involve active drug efflux pumps, outer membrane impermeability as well as drug inactivating enzymes. These findings demonstrate the fundamental importance of the in vitro susceptibility testing of antibiotics prior to antipseudomonal therapy and highlight the need for a continuous antimicrobial resistance surveillance programs to monitor the changing resistance patterns so that clinicians and health care officials are updated as to the most effective therapeutic agents to combat the serious outcomes of P. aeruginosa infections. This copy is for personal use only -distribution prohibited.El Zowalaty M.E. and Gyetvai B.1 24 anti biotics (El Zowalaty et al., 2015). The literature is rich in surveillance studies from all over the world reporting varying resistance rates among P. aeruginosa against different antimicrobial agent. Recently, studies have focused on the decreased susceptibility of P. aeru ginosa to currently used antipseudomonal agents, including β-lactams, aminoglycosides, and fluoroquinolones (Al-Tawfiq, 2007) since resistance of P. aeru ginosa to carbapenems, piperacillin, and other highly active antibiotics has emerged and is increasing which makes treatment of P. aeruginosa infections troublesome (Strateva et al., 2007).Recently, resistance rates of P. aeruginosa clinical isolates recovered from patients admitted to Zagazig University hospitals in Egypt against different classes of antimicrobial agents were reported (El Zowalaty, 2012). The current study further examined the susceptibilities and possible resistance mechanisms of P. aeruginosa isolates collected from hospitalized patients against selected antipseudomonal agents that are available in the Egyptian pharmaceutical market and are frequently prescribed to patients. Experimental Materials and MethodsStudy site. The specimens were collected from ...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effectiveness of Antipseudomonal Antibiotics and Mechanisms of Multidrug Resistance in Pseudomonas aeruginosa

Zowalaty

Gyetvai

2016

Polish Journal of Microbiology

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“…Globally, the differences in the resistance rates of P. aeruginosa usually correlate with the prescription patterns of antibiotics by physicians, overuse of antibiotics, and the selective pressure of certain antibiotics. 11 Recent, studies showed that susceptibility of P. aeruginosa to currently used anti-pseudomonal agents, including ß-lactams, aminoglycosides, and fluoro-quinolones is decreasing. 12 Since resistance of P. aeruginosa to carbapenems, piperacillin, and other highly active antibiotics has emerged and is increasing, it makes treatment of P. aeruginosa infections troublesome.…”

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confidence: 99%

Antibiotic resistance pattern in pseudomonas aeruginosa isolated from a private Medical College Hospital

Siddiqua¹,

Alam

Akter³

et al. 2018

KYAMC j.

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Background: Pseudomonas aeruginosa is an aerobic, motile, gram negative rod that belongs to the family, Pseudomonadaceae. They are often multidrug resistant due to intrinsic and acquired determinants. Continued emergence of resistance among P. aeruginosa to common antimicrobial drugs has been reported world-wide.Objectives: This study investigated the antimicrobial resistance as well as susceptibility patterns of isolates of P. aeruginosa in clinical specimens.Materials & Methods: One hundred and thirty-eight isolates of Pseudomonas aeruginosa were obtained from 4489 different clinical specimens. Antimicrobial susceptibility pattern of each isolate was carried out by the Kirby- Bauer disk diffusion method as per guidelines of Clinical Laboratory Standard Institute (CLSI).Results: Majority of isolates of P. aeruginosa were obtained from specimens of wound swab 89 (64.5%), pus 18 (13.05%), and urine 17 (13.1%). The isolated pathogens showed high resistance (91% to 96%) to cotrimoxazole and cefuroxime. Resistance rates to cefepime, ceftriaxone, cefotaxime, and gentamicin varied from 47% to 88%. All the isolates were comparatively better susceptible to meropenem, ciprofloxacin, amikacin and imipenem ranges from 76% to 87%.Conclusion: The results confirmed the occurrence of drug resistance of P. aeruginosa to anti-pseudomonal drugs. Imipenem, amikacin, ciprofloxacin and meropenem were found to be the most effective antimicrobial drugs. Therefore, judicious and rational treatment prescription is needed by the physicians to limit the further spread of antimicrobial resistance among the P. aeruginosa.KYAMC Journal Vol. 9, No.-1, April 2018, Page 16-19

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“…2 Resistensi antimikrob merupakan salah satu masalah kesehatan masyarakat yang dihadapi manusia sejak era ditemukan antimikrob. 3 P. aeruginosa merupakan salah satu bakteri yang memiliki semua mekanisme resistensi yang diketahui.…”

Section: Pendahuluanunclassified

“…Angka resistensi ini sangat bervariasi secara geografis, dilaporkan rendah di beberapa negara, namun sangat tinggi di beberapa negara lain. 3 Laporan angka resistensi P. aeruginosa termasuk prevalensi multidrug resistant P. aeruginosa (MDR P.a eruginosa), di Indonesia khususnya di Pekanbaru sangat terbatas.…”

Section: Pendahuluanunclassified

Prevalensi dan Pola Sensitivitas Antimikroba Multidrug Resistant Pseudomonas aeruginosa di RSUD Arifin Achmad

Anggraini¹,

Yulindra²,

Savira³

et al. 2018

mkb

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AbstrakResistensi antimikrob merupakan salah satu masalah kesehatan masyarakat yang besar yang dihadapi manusia sejak era ditemukan antimikrob. Angka multidrug resistant P. aeruginosa salah satunya semakin meningkat di berbagai belahan dunia yang berdampak pada kesulitan penanganan infeksi oleh bakteri ini. Penelitian deskriptif retrospektif ini bertujuan mengetahui prevalensi MDR P.aeruginosa dan pola sensitivitasnya. Data diambil dari hasil kultur bakteri dan uji resistensi antibiotik dari berbagai spesimen klinis pasien di RSUD Arifin Achmad sepanjang tahun 2015. Uji resistensi dilakukan dengan menggunakan alat Vitek 2 compact. MDR P. aeruginosa didefinisikan sebagai P. aeruginosa yang tidak sensitif terhadap tiga atau lebih golongan antibiotik berikut: meropenem atau imipenem, siprofloksasin, gentamisin atau amikasin, seftazidim atau sefepim, dan piperasilin/ tazobaktam. Prevalensi MDR P. aeruginosa adalah 45,5%. Isolat MDR P. aeruginosa serta paling banyak berasal dari instalasi perawatan surgikal dan instalasi perawatan intensif, dan paling banyak berasal dari spesimen pus dan sputum. Sensitivitas P. aeruginosa paling baik dengan amikasin (76,9%), piperasilin/tazobaktam (57,2%), meropenem (57,0%), gentamisin (54,5%), sefepim (53,7%), seftazidim (49,6%), ciprofloksasin (48,8%) dan aztreonam (35,5%). Sensitivitas MDR P.aeruginosa terhadap antibiotik jauh lebih rendah dibanding dengan P. aeruginosa. Penelitian ini menunjukkan angka MDR P. aeruginosa tinggi khususnya di Pekanbaru. Pola sensitifas P. aeruginosa dapat menjadi pedoman dalam memilih antibiotik yang sesuai untuk infeksi karena P. aeruginosa. Kata kunci: Multidrug resistant, Pekanbaru, pseudomonas aeruginosa, sensitivitas antibiotik Prevalence and Antimicrobial Susceptibility Profile of Multidrug Resistant Pseudomonas aeruginosa in Arifin Achmad General Hospital AbstractAntimicrobial resistance is one of major public health problems since the era of antimicrobial discovery, inclusing multidrug resistant (MDR) P. aeruginosa. The prevalence of this resistance is increasing in different parts of the world, leading to the difficulties in dealing with this bacteria. The aim of this descriptive retrospective study was to determine the prevalence of MDR P. aeruginosa and its susceptibility profile. Data were collected from the bacteria cultures and antibiotic susceptibility test results from various clinical specimens in Arifin Achmad General Hospital throughout 2015. The test was performed in VITEK 2 Compact. MDR P. aeruginosa is defined as P. aeruginosa which is not sensitive to three or more following antibiotics: meropenem or imipenem, ciprofloxacin, gentamicin or amikacin, ceftazidime or cefepime, and piperacilin/tazobactam. The prevalence of MDR P. aeruginosa was 45.5%. The isolates of MDR P. aeruginosa was mostly derived from pus and sputum specimens from the surgical ward and intensive care unit. The most sensitive antibiotics was amikacin (76.9%) followed by piperacilin/tazobactam (57.2%), meropenem (57.0%), gentamicin (54.5%), cefepime (53.7%), c...

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Pseudomonas Aeruginosa : Arsenal of Resistance Mechanisms, Decades of Changing Resistance Profiles, and Future Antimicrobial Therapies

Cited by 127 publications

References 203 publications

Effectiveness of Antipseudomonal Antibiotics and Mechanisms of Multidrug Resistance in Pseudomonas aeruginosa

Effectiveness of Antipseudomonal Antibiotics and Mechanisms of Multidrug Resistance in Pseudomonas aeruginosa

Antibiotic resistance pattern in pseudomonas aeruginosa isolated from a private Medical College Hospital

Prevalensi dan Pola Sensitivitas Antimikroba Multidrug Resistant Pseudomonas aeruginosa di RSUD Arifin Achmad

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