<i>Propionibacterium avidum </i>as the cause of severe breast infection following reduction mammoplasty

Levin, Brett; Foo, Hong; Lee, Andie; Gottlieb, Tom

doi:10.1111/j.1445-2197.2008.04450.x

Cited by 8 publications

(6 citation statements)

References 5 publications

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“…According to the literature available there have been reports of SSI after breast reduction [6,7], post-mastectomy [8], abdominal parietoplasty [9], periprosthetic infections [10], prosthetic valve endocarditis [11], and sacroiliitis after herniorrhaphy [12]. Post-procedural infections, including splenic abscess after coronary bypass [13], and cardiac catheterization [14] have also been described in immunocompetent patients [15].…”

Section: Discussionmentioning

confidence: 99%

Cutibacterium avidum: A rare but expected agent of breast implant infection

Ramírez

Manrique

2019

IDCases

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Section: Discussionmentioning

confidence: 99%

Cutibacterium avidum: A rare but expected agent of breast implant infection

Ramírez

Manrique

2019

IDCases

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“…Briefly, the initial choice was to administer beta-lactamase-resistant penicillins IV, followed by an oral replacement for up to 1 month. For possible penicillin allergies [ 2 ], an IV carbapenem (meropenem) was used prior to an oral fluoroquinolone (moxifloaxacin). Propionibacterium avidum is likely to be found in the presence of implanted foreign materials.…”

Section: Discussionmentioning

confidence: 99%

Propionibacterium avidum infection following breast reduction: high morbidity from a low-virulence pathogen

Summa

Yvon²,

Larcher³

et al. 2015

Journal of Surgical Case Reports

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Propionibacterium avidum is a common inhabitant of sebaceous glands, traditionally considered to be of low virulence and generally found on implanted foreign material. We report a rare case of P. avidum breast abscess, causing severe morbidity following breast reduction surgery. A 36-year-old woman presented with a non-painful wound discharge 3 weeks postoperatively, and was treated conservatively. She was readmitted 7 weeks postoperatively with a red and tender breast. A purulent discharging abscess was drained under ultrasound guidance. A 2-week intravenous course of amoxicillin–clavulanic acid, followed by oral replacement for a month resulted effective. Serial ultrasound imaging was useful in treatment decision-making. The infective potential of P. avidum may be underappreciated. Proximity of sutures to the axilla, tobacco smoking and the potential for resorbable sutures to host bacteria may predispose to infection, and should raise the clinician's awareness.

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“…In this context, and despite the absence of foreign-body material, the development of C. avidum led to severe infection by virtue of its ability to adhere but also to grow and create abscesses, as reported previously (Table 5). Moreover, the decrease in inoculum by excellent debridement and a prolonged course of antibiotics may play a crucial role in the successful treatment of severe breast infections following reduction mammoplasty (16). Persistence and biofilm production ability were suspected by Mak et al on comparing the genomes of several Cutibacterium species and were later confirmed by Wildeman et al by specific and extended genomic analysis of C. avidum genomes (13,14).…”

Section: Breast Infectionsmentioning

confidence: 99%

“…Other Gram-positive pathogens are able to produce lipase, such as bacteria of the Burkholderia cepacia complex, with an impact in lung epithelial cell invasion (61), and Candida parapsilosis, a skin commensal for which lipase modulates the immune response of macrophages (62). Future studies clearly need to be performed to investigate the pathogenesis of C. avidum infection, especially in liponecrotic breast abscess or skin necrosis (15)(16)(17)32).…”

Section: Lipasementioning

confidence: 99%

“…Although often defined as a commensal (12,13), C. avidum has likely been underestimated, unrecognized, and misidentified in more than a few clinical cases. Despite its low frequency in human infections, numerous associated or invasive infections have been reported: bone infections, infective endocarditis (IE), breast infections, abdominal infections, prostate infections, and splenic and skin abscesses have been described, sometimes with significant collateral damage for the patient (14)(15)(16)(17). In my experience, although one cannot avoid bias according to the identification method used and the awareness of microbiologists, there has been a clearly observed increase in C. avidum-positive samples over the past years.…”

Section: Introductionmentioning

confidence: 99%

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Clinical and Biological Features of Cutibacterium (Formerly Propionibacterium)avidum, an Underrecognized Microorganism

Corvec

2018

Clin Microbiol Rev

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The recent description of the genus has altered the taxonomy of species. These organisms still belong to the genera of the skin coryneform group, and the most-studied species remains . is also a known skin commensal. This underrecognized microorganism can, however, act as a pathogen after bacterial seeding and can be considered opportunistic, causing either superficial or deep/invasive infections. It can cause numerous infections, including but not limited to breast infections, skin abscesses, infective endocarditis, and device-related infections. The ecological niche of is clearly different from that of other members of the genus: it is found in the axillary region or at wet sites rather than in dry, exposed areas, and the number of microorganisms increases during puberty. Historically, it has been used for its ability to modulate the immune response and for its antitumor properties. Conventional microbial culture methods and identification processes allow for its accurate identification and characterization. Thanks to the modern omics tools used for phylogenomic approaches, understanding pathogenesis (including host-bacterium interactions and virulence factor characterization) is becoming easier, allowing for more thorough molecular characterization. These analyses have revealed that causes diverse diseases mediated by multiple virulence factors. The recent genome approach has revealed specific genomic regions within this species that are involved in adherence and biofilm formation as well as fitness, survival, and defense functions. Numerous regions show the presence of phages and horizontal gene transfer. remains highly sensitive to a broad spectrum of antibiotics, such as β-lactams, fluoroquinolones, macrolides, and rifampin, although erythromycin and clindamycin resistance has been described. A long-term treatment regimen with a combination of antibiotics is required to successfully eliminate the remaining adherent bacteria, particularly in the case of deep infections after debridement surgery.

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Propionibacterium avidum as the cause of severe breast infection following reduction mammoplasty

Cited by 8 publications

References 5 publications

Cutibacterium avidum: A rare but expected agent of breast implant infection

Cutibacterium avidum: A rare but expected agent of breast implant infection

Propionibacterium avidum infection following breast reduction: high morbidity from a low-virulence pathogen

Clinical and Biological Features of Cutibacterium (Formerly Propionibacterium)avidum, an Underrecognized Microorganism

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