The year 2016 was the hundredth anniversary of the publication of John Maurice Clark's "The Changing Basis of Economic Responsibility" in the Journal of Political Economy. Clark's article is a seminal contribution to the understanding of economic responsibility and thus to a topic underresearched in management studies, business ethics, and economic ethics. The current article reconstructs Clark's approach based on the classical model of responsibility and outlines his ideas about the role of an "economics of responsibility" for economic responsibility and a society's business ethics in practice.