<i>Porphyromonas asaccharolytica</i> as a Rare Causative Agent for Lemierre’s Syndrome

Gupta, Mridul; Annam, Radhika; Bahgat, Joseph; Eng, Margaret

doi:10.1155/2018/3628395

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…to the geographical location [19,20]. Some resident bacteria in the peripheral organs have been detected, including bacteria isolated from the oral cavity in CSOM and MEC, such as Gemella morbillorum, Porphyromonas sp., Fusobacterium nucleatum, and Porphyromonas asaccharolytica [21][22][23], further con rming that the bacteria in COM may originate from adjacent organs [24]. Bacteria may enter the middle ear cavity through the eustachian tube under certain conditions, leading to COM formation [25].…”

Section: Discussionmentioning

confidence: 99%

Microbiome analysis of chronic suppurative otitis media and middle-ear cholesteatoma in China

Long

et al. 2023

Preprint

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Here, the bacterial diversity in chronic suppurative otitis media (CSOM) and middle-ear cholesteatoma (MEC) was analysed. Nine and twenty-nine patients with CSOM and MEC, respectively, were recruited. Middle-ear lesion tissue was collected intraoperatively after opening the tympanic sinus and mastoid cavity under general anaesthesia and sterile conditions. The full-length 16S rRNA genome sequenced using third-generation sequencing (TGS) was then used to profile the bacterial community of each patient. Principal coordinate analysis showed that PC1 and PC2 could explain more than 50% of the between-group differences. Similarity analysis using the binary Jaccard distance matrix indicated that between-group differences were greater than within-group differences (P < 0.05). Staphylococcus aureus was the most common strain in both groups. At the species level, the abundance of Anaerococcus_octavius was significantly different between both groups (P < 0.05). According to the linear discriminant effect size analysis, at the class and genus levels, Alphaproteobacteria and Bacillus were abundant in the CSOM group, respectively. Peptoniphilus_grossensis and Peptostreptococcaceae_bacterium_oral_taxon_929 were abundant at the species level in the MEC group (P < 0.05). Four COG (Clusters of Orthologous Groups ) functions at level 2 were significantly different between the two groups (P < 0.05). The CSOM and MEC groups were inhabited by more diverse microbial communities. This could guide the regular use of antibiotics and decrease the likelihood of multidrug-resistant bacteria formation. Further research on the pathogenic diseases of CSOM and MEC will focus on the functional differences between flora.

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Section: Discussionmentioning

confidence: 99%

Microbiome analysis of chronic suppurative otitis media and middle-ear cholesteatoma in China

Long

et al. 2023

Preprint

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“…The meta-analysis also detected non-resident bacteria in the oral cavity, such as Bacteroides fragilis and Spirochete/Treponema at 1.0% and 0.3%. Porphyromonas asaccharolytica is a bacterium common in the urogenital and intestinal tracts [14]. This suggests that part of LS should be recognised as a sexually transmitted disease rather than a simple invasion of oral commensals.…”

Section: Discussionmentioning

confidence: 99%

Lemierre’s Syndrome as a Sexually Transmitted Disease Due to Porphyromonas asaccharolytica Suspected to Be Caused by Pharyngitis Due to Mycoplasma pneumoniae and Epstein-Barr Virus

Ueno¹,

Horiuchi²,

Utada³

et al. 2022

Cureus

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Porphyromonas asaccharolytica rarely causes Lemierre's syndrome (LS), which is characterised by sepsis and thrombophlebitis of the internal jugular vein.An 18-year-old man presented with fever and a sore throat after sexual contact containing oral sex, and his blood sample was positive for atypical lymphocytes. Infectious mononucleosis was suspected initially. However, laboratory data showed elevated D-dimer and procalcitonin levels, and a computed tomography scan showed a thrombus in the internal jugular vein leading to the diagnosis of LS. The Mycoplasma pneumoniae (MP) IgM titre was 1:640 (normal, ≦1:40), and the Epstein-Barr nuclear antigen titre (taken 59 days after admission) was 1:10 (normal, <1:10). It was assumed that LS developed after infection with Epstein-Barr virus (EBV) and MP.LS should be suspected in young patients with fever and sore throat with a history of recent sexual contact. As pharyngitis was considered the cause of LS, evaluation of the preceding infection such as MP or EBV leading to pharyngitis should also be considered.

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Lemierre's syndrome: varying pathogens, clinical presentations and complications

Lampejo,

Alsheikh,

Crilly

et al. 2024

Diagnostic Microbiology and Infectious Disease

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Porphyromonas asaccharolytica as a Rare Causative Agent for Lemierre’s Syndrome

Cited by 4 publications

References 15 publications

Microbiome analysis of chronic suppurative otitis media and middle-ear cholesteatoma in China

Microbiome analysis of chronic suppurative otitis media and middle-ear cholesteatoma in China

Lemierre’s Syndrome as a Sexually Transmitted Disease Due to Porphyromonas asaccharolytica Suspected to Be Caused by Pharyngitis Due to Mycoplasma pneumoniae and Epstein-Barr Virus

Lemierre's syndrome: varying pathogens, clinical presentations and complications

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