<i>Polygonum viviparum</i> L. inhibits the lipopolysaccharide‐induced inflammatory response in RAW264.7 macrophages through haem oxygenase‐1 induction and activation of the Nrf2 pathway

Cheng, Hui-Wen; Lee, Kock-Chee; Cheah, Khoot-Peng; Chang, Ming-Long; Lin, Che-Wei; Li, Joe-Sharg; Yu, Wenyu; Liu, E-Tung; Hu, Chien-Ming

doi:10.1002/jsfa.5795

Cited by 13 publications

(13 citation statements)

References 25 publications

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“…It has, in fact, been shown that the expression of HO-1 is crucial in inhibiting LPS-induced proinflammmatory responses in RAW 264.7 cells and that ROS mediates the induction of HO-1 in a redox-regulated pathway [23], [25].…”

Section: Resultsmentioning

confidence: 99%

Astaxanthin Treatment Confers Protection against Oxidative Stress in U937 Cells Stimulated with Lipopolysaccharide Reducing O2− Production

et al. 2014

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Recently, astaxanthin (ASTA) studies have focused on several biological functions such as radical scavenging, singlet oxygen quenching, anti-carcinogenesis, anti-diabetic, anti-obesity, anti-inflammatory, anti-melanogenesis, and immune enhancement activities. In this study, we investigated the potential role protective of ASTA, an antioxidant marine carotenoid, in restoring physiological conditions in U937 cells stimulated with LPS (10 µg/ml). Our results show that pre-treatment with ASTA (10 µM) for 1 h attenuates the LPS-induced toxicity and ROS production. The beneficial effect of ASTA is associated with a reduction intracellular O2 − production by restoring the antioxidant network activity of superoxide dismutase (SOD) and catalase (CAT), which influence HO-1 expression and activity by inhibiting nuclear translocation of Nrf2. We accordingly hypothesize that ASTA has therapeutic properties protecting U937 cells from LPS-induced inflammatory and oxidative stress.

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Section: Resultsmentioning

confidence: 99%

Astaxanthin Treatment Confers Protection against Oxidative Stress in U937 Cells Stimulated with Lipopolysaccharide Reducing O2− Production

et al. 2014

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“…Nuclear factor erythroid 2 (NF‐E2)‐related factor 2 (Nrf2), a key transcription factor for antioxidant mechanism, which is tightly regulated by Kelch‐like ECH‐associated protein 1 (Keap1)/Cullin3 (Cul3), affects GSH synthesis and redox state through inducing and upregulating antioxidant responsive element (ARE)‐dependent gene expressions, such as glutamate cysteine ligase catalytic subunit (GCLC), glutamate cysteine ligase modulatory subunit (GCLM), GS, superoxide dismutase (SOD), catalase (CAT), NAD(P)H:quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO‐1), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S ‐transferase (GST), etc . In view of these facts, the Nrf2‐ARE pathway is regarded as playing a critical role in stimulating GSH synthesis and inducing endogenous antioxidant response to depress ROS‐derived oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

l‐Methionine activates Nrf2‐ARE pathway to induce endogenous antioxidant activity for depressing ROS‐derived oxidative stress in growing rats

Wang

Liang

et al. 2019

J Sci Food Agric

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BACKGROUND Methionine is an essential sulfur‐containing amino acid. To elucidate the influence of l‐methionine on activation of the nuclear factor erythroid 2‐related factor 2–antioxidant responsive element (Nrf2‐ARE) antioxidant pathway to stimulate the endogenous antioxidant activity for depressing reactive oxygen species (ROS)‐derived oxidative stress, male Wistar rats were orally administered l‐methionine daily for 14 days. RESULTS With the intake of l‐methionine, Nrf2 was activated by l‐methionine through depressing Keap1 and Cul3, resulting in upregulation of ARE‐driven antioxidant expression (glutamate cysteine ligase catalytic subunit, glutamate cysteine ligase modulatory subunit, glutathione synthase (GS), catalase (CAT), superoxide dismutase (SOD), heme oxygenase 1, NAD(P)H:quinone oxidoreductase 1, glutathione reductase (GR), glutathione S‐transferase (GST), glutathione peroxidase (GPx)) with increasing l‐methionine availability. Upon activation of Nrf2, glutathione synthesis was increased through upregulated expression of methionine adenosyltransferase, S‐adenosylhomocysteine hydrolase, cystathionine β‐synthase, cystathionine γ‐lyse, glutamate cysteine ligase (GCL) and GS, while hepatic expressions of methionine sulfoxide reductases (MsrA, MsrB2, MsrB3) and hepatic enzyme activities (CAT, SOD, GCL, GR, GST, GPx) were uniformly stimulated with increasing consumption of l‐methionine. As a result, hepatic content of ROS and MDA were effectively reduced by l‐methionine intake. CONCLUSION The present study demonstrates that methionine availability plays a critical role in activation of the Nrf2‐ARE pathway to induce an endogenous antioxidant response for depressing ROS‐derived oxidative stress, which is primarily attributed to the stimulation of methionine sulfoxide reductase expression and glutathione synthesis. © 2019 Society of Chemical Industry

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“…chinense aqueous leaf extract has gastroprotective activity on ethanol-induced hemorrhagic mucosal lesions in rats (Ismail et al, 2012). P. viviparum inhibits the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through heme oxygenase-1 induction and activation of the Nrf2 pathway (Cheng et al, 2013).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…The genetic diversity of 48 representational populations of P. capitatum including 240 individuals was investigated by ISSR marker (Zhou et al, 2010). SRAP (sequence-related amplified polymorphism) was used to detect the polymorphisms of Radix Polygoni Multiflori in Chongqing (Cheng et al, 2013). SRAP might be superior to RAPD in genetic diversity studies.…”

Section: Molecular Markermentioning

confidence: 99%

Phytochemical and biological research of Polygoneae medicinal resources

Hao¹,

Gu²,

Xiao³

2015

Medicinal Plants

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Polygonum viviparum L. inhibits the lipopolysaccharide‐induced inflammatory response in RAW264.7 macrophages through haem oxygenase‐1 induction and activation of the Nrf2 pathway

Abstract: These results suggest that PV possesses anti-inflammatory actions in macrophages and works through a novel mechanism involving Nrf2 actions and HO-1. Thus PV could be considered for application as a potential therapeutic approach for inflammation-associated disorders.

Cited by 13 publications

References 25 publications

Astaxanthin Treatment Confers Protection against Oxidative Stress in U937 Cells Stimulated with Lipopolysaccharide Reducing O2− Production

Astaxanthin Treatment Confers Protection against Oxidative Stress in U937 Cells Stimulated with Lipopolysaccharide Reducing O2− Production

l‐Methionine activates Nrf2‐ARE pathway to induce endogenous antioxidant activity for depressing ROS‐derived oxidative stress in growing rats

Phytochemical and biological research of Polygoneae medicinal resources

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