<i>Plasmodium vivax</i>Malaria

Kochar, Dhanpat Kumar; Saxena, Vishal; Singh, Narvachan; Kochar, Sanjay Kumar; Kumar, Shruti; Das, Ashis

doi:10.3201/eid1101.040519

Cited by 341 publications

(253 citation statements)

References 8 publications

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“…La malaria complicada se atribuye a las infecciones por Plasmodium falciparum (3), aunque también puede ser causada por P. vivax (4)(5)(6)(7)(8) y, recientemente, se han informado complicaciones Tobón-Castaño A, Giraldo-Castro C, Blair S y muertes por P. knowlesi (9). El paciente puede evolucionar en un corto tiempo a un estado grave con alto riesgo de muerte; en el transcurso de la enfermedad pueden manifestarse signos clínicos o parasitológicos que se han relacionado con mayor riesgo de complicación clínica, conocidos como signos de peligro.…”

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Prognostic value of clinical and parasitological signs for severe malaria in patients from Colombia

2012

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Introducción. El pronto reconocimiento de los signos de peligro en los pacientes con malaria puede reducir las complicaciones y muertes. Sin embargo, se conoce poco sobre su valor pronóstico para la malaria complicada, especialmente en las zonas de transmisión baja e inestable de la enfermedad. Objetivo. Estimar el valor pronóstico de gravedad que tienen diversos signos clínicos y parasitológicos en los pacientes con malaria. Materiales y métodos. Se hizo un estudio en una cohorte prospectiva con pacientes de cinco municipios de Colombia, con diagnóstico de malaria por Plasmodium falciparum y P. vivax, en quienes se estudió la asociación de los signos clínicos y los parasitológicos con la malaria complicada. Resultados. Se obtuvo un modelo de predicción con una sensibilidad de 47,4 % y especificidad de 92,8 %, valor pronóstico positivo de 63,2 % y valor pronóstico negativo de 87,1 %, el cual incluye ictericia, orina oscura, hiperpirexia y signos de deshidratación. Conclusiones. Con el fin de causar un impacto en la morbilidad complicada de la malaria, se propone una estrategia de reconocimiento de los signos de peligro por el personal no médico, que se acompañe de otros elementos de la atención, como el suministro de un tratamiento antipalúdico adecuado y oportuno. Se proponen los criterios del diagnóstico de complicación moderada. Palabras clave: malaria, signos y síntomas, Plasmodium falciparum, Plasmodium vivax. Prognostic value of clinical and parasitological signs for severe malaria in patients from ColombiaIntroduction. Early recognition of danger signs in patients with malaria can reduce complications and deaths, but little is known about their prognostic value for severe malaria, especially in areas of low transmission and unstable malaria. Objective. To assess the prognostic value for severity of different clinical and parasitological signs in patients with malaria. Materials and methods. A prospective cohort of patients from five municipalities in Colombia with diagnosis of Plasmodium falciparum or P. vivax malaria in whom the association between clinical and parasitological signs with complicated malaria was studied. Results. A predictive model with 47.4% sensitivity, 92.8% specificity, 63.2% positive predictive value and 87.1% negative predictive value was obtained which includes jaundice, dark urine, hyperpyrexia and signs of dehydration. Conclusions. To impact the morbidity of complicated proposed a strategy is proposed for the early recognition of danger signs by non-medical personnel, which could be complemented by other elements of health care, such as providing adequate and appropriate antimalarial treatment. Diagnostic criteria for moderate complication are also proposed.

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Prognostic value of clinical and parasitological signs for severe malaria in patients from Colombia

2012

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“…The result of present study indicated that maximum of 36 (27.9%) and 28 (21.7%) were seen in the month of July and August and minimum 6 (4.6%) and 5 (3.8%) were seen in the month of November Table [5].This matched the results of the study done by Idris M Z et al 21 (2014) conducted two cross-sectional surveys during the dry July , August and two consecutive November and December. (31.1%) were higher in the July and august than in the (5.3%) in November and December.…”

Section: Pbs Cbcsmentioning

confidence: 71%

“…The nonspecific nature of the clinical signs and symptoms of malaria may result in over-treatment of malaria or nontreatment of other diseases in malaria-endemic areas, and miss diagnosis in non-endemic areas. 5 In the laboratory, malaria is diagnosed using different techniques, e.g. conventional microscopic diagnosis by staining thin and thick peripheral blood smears, other concentration techniques, e.g.…”

Section: Int J Adv Res 5(4) 1154-1163mentioning

confidence: 99%

Differential Diagnosis of Malaria by Peripheral Blood Smear, Antigen Detection and Centrifuged Buffy Coat Smear Examination.

Prabhas¹,

Garg²,

Singh³

et al. 2017

IJAR

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Purpose: Malaria continues to be a global public health challenge especially in the tropical and sub-tropical countries. Control and eradication of malaria have become very challenging issues and requires prompt treatment to save the patient's life, which in turn requires a rapid and accurate diagnosis. Several approaches have been developed in recent times to enable early and reliable diagnosis of malaria. Each of the techniques has their own advantages and disadvantages. The present study was undertaken to assess the usefulness of a modified centrifuged buffy coat smear (CBCS) technique for diagnosis of malaria and to compare it with a antigen detection test and conventional PBS examination. Material and methods: The present study was conducted on the blood samples of patients with suspected case of Malaria received in the department of Microbiology MMIMSR, Mullana. 50 positive samples were taken by RDT and then compared with PBF and CBC. The present study demonstrated the performance of a modified technique for diagnosis of malaria by incorporating a centrifugation-enhanced step into the conventional method of smear preparation and examination for malaria. This helps to concentrate the parasites, which are then easily visualized by microscopy and compared with rapid diagnostic test by antigen detection kit and conventional peripheral blood smear. Results: It was observed that while both PBS (100%) and CBCS (100%) had excellent specificity, But PBS had low sensitivity (94%) in detecting the malaria parasites as compared with CBCS (100%). Conclusion: It was concluded that CBCS is an easy, rapid and accurate technique and could be adopted for reliable diagnosis of malaria in resource-limited settings where RDT and QBC may prove to be costlier options.

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“…Las complicaciones hepáticas se han descrito en los casos de malaria causados por todas las especies en humanos (18,19), generalmente asociadas con la ictericia, la cual se observa en las escleróticas cuando la bilirrubina supera los 3 mg/dl (20), y puede obedecer también a la hemólisis (21). La ictericia se considera una de las manifestaciones clínicas de complicación más comunes en pacientes con malaria por P. falciparum (10-40 %) (8) y alcanza una frecuencia de hasta 9 % en la causada por P. vivax.…”

Section: Hallazgos De La Revisiónunclassified

Urinalysis as a diagnostic tool in severe malaria

Barrera

Tobón-Castaño

2017

biomedica

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Recibido: 15/07/16; aceptado: 26/02/17 Contribución de los autores:Sebastián Barrera: búsqueda bibliográfica y escritura del manuscrito Alberto Tobón: búsqueda bibliográfica, revisión crítica, corrección y escritura del manuscrito Los dos autores participaron en la escritura del manuscrito. La malaria produce complicaciones y muerte especialmente en poblaciones con acceso limitado a la atención en salud. La malaria grave puede reconocerse tempranamente mediante la detección en la orina de hallazgos como la hematuria, la coluria y la proteinuria. Se hizo una revisión narrativa basada en estudios sobre malaria grave y el empleo del análisis de orina mediante la consulta de 91 publicaciones. Mediante el análisis de la orina, se pueden detectar alteraciones metabólicas y lesiones en distintos órganos. En estudios recientes en Colombia se ha confirmado su utilidad como apoyo en el diagnóstico de la disfunción renal, la disfunción hepática y la anemia asociada con hemólisis, las cuales son complicaciones frecuentes en la malaria. El examen constituye una herramienta de fácil aplicación en la consulta ambulatoria y en pacientes hospitalizados para reconocer tempranamente casos complicados, y permite la detección oportuna de diferentes lesiones en el paciente con malaria, contribuyendo así a la reducción de la morbilidad grave y la mortalidad.Palabras clave: malaria, proteinuria, hematuria.doi: https://doi.org/10.7705/biomedica.v34i2.3416 Urinalysis as a diagnostic tool in severe malariaMalaria accounts for a significant morbidity and mortality rate around the world, especially in communities with limited access to healthcare. Some clinical signs in urine, like haematuria, coluria and proteinuria, help for the early diagnosis of severe malaria cases. A narrative review was conducted by analyzing 91 publications on studies about severe malaria cases and the use of urinalysis. A urinalysis can detect metabolic disturbances and organ injury. Its diagnostic utility for frequent complications caused by malaria, such as hepatic injury, kidney dysfunction and hemolysis, has been confirmed by recent Colombian studies. This test is an easy-to-use tool in outpatient clinics and with hospitalized patients to promptly recognize complicated cases, allowing the timely identification of different lesions in patients with malaria, thus contributing to the reduction of severe morbidity and mortality. La malaria es una enfermedad que afecta principalmente a las comunidades que habitan en regiones tropicales en donde constituye un importante problema de salud pública; las poblaciones afectadas tienen, en general, un acceso limitado a la atención en salud y a los recursos diagnósticos.En 2015 se informó una incidencia de 214 millones de casos clínicos y 438.000 muertes, la mayoría en el África subsahariana (1). La malaria afecta de manera importante a los niños, grupo que representó el 16 % del total de casos en 2015 (2) y se consideró la causa de 7 % de las muertes

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Plasmodium vivaxMalaria

Cited by 341 publications

References 8 publications

Prognostic value of clinical and parasitological signs for severe malaria in patients from Colombia

Prognostic value of clinical and parasitological signs for severe malaria in patients from Colombia

Differential Diagnosis of Malaria by Peripheral Blood Smear, Antigen Detection and Centrifuged Buffy Coat Smear Examination.

Urinalysis as a diagnostic tool in severe malaria

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