<i>Plasmodium falciparum</i>and Helminth Coinfection in a Semiurban Population of Pregnant Women in Uganda

Hillier, Stephen D.; Booth, Mark; Muhangi, Lawrence; Nkurunziza, Peter; Khihembo, Macklyn; Kakande, Muhammad; Sewankambo, Moses; Kammerer, Robert; Kizza, Moses; Muwanga, Moses; Elliott, Alison M.

doi:10.1086/591183

Cited by 82 publications

(91 citation statements)

References 43 publications

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“…This association may have been a result of the host-parasite relationship, particularly in HIV infection. One of the reasons for this coinfection could be due to behavioural or environmental factors leading to increased exposure to these parasitic agents [21]. For example, Table 3.…”

Section: Discussionmentioning

confidence: 99%

Plasmodium falciparum and intestinal parasitic co-infections in HIV-infected patients in Benin City, Edo State, Nigeria

Akinbo

Okaka

Omoregie

2011

J Infect Dev Ctries

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Introduction: Human co-infection with Plasmodium falciparum and helminthes is ubiquitous throughout Africa. This study aimed to determine the co-infections of Plasmodium falciparum infection in HIV and intestinal parasitic infections, and their immunological distribution, in Benin City, Nigeria. Methodology: A total of 2,000 stool specimens from HIV-positive patients and 500 controls (HIV-negative individuals) were examined for ova, cysts, or parasites using standard procedures. In addition, patients' blood samples were analyzed for CD4 counts by flow cytometry and examined for Plasmodium falciparum by microscopy. Results: The prevalence of single parasitic infection among HIV patients was 18.1% in males and 16.9% among females with no significant difference (p = 0.536) while gender was a risk factor in multiple parasitic infections (male versus female: 4.2% and 1.8% OR = 2.384; 95% CI = 1.371, 4.147) (p = 0.0025). Increasing age was not associated with increased risk of both single and multiple parasitic infections (p = 0.083; p = 0.248). CD4 + T cell count less than 200 cells/µl was a risk factor for acquiring single and multiple parasitic infections among HIV patients (OR = 5.565; 95% CI = 4.136, 7.486; p = 0.0001; OR = 4.283; 95% CI = 2.424, 7.566; p = 0.0001). The most common co-infection observed was between Plasmodium falciparum and Ascaris lumbricoides 43% (10) among HIV patients. Conclusion: This study provides evidence of co-infections between Plasmodium falciparum and intestinal parasites. Diagnosis of parasitic infections among HIV patients is advocated as this will enhance better management of HIV-infected patients.

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Section: Discussionmentioning

confidence: 99%

Plasmodium falciparum and intestinal parasitic co-infections in HIV-infected patients in Benin City, Edo State, Nigeria

Akinbo

Okaka

Omoregie

2011

J Infect Dev Ctries

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“…13,14 In addition, consistent with prior studies, our findings suggest that hookworm infection may exacerbate malaria infections among pregnant women. 23,28 Hillier and others 23 showed that hookworm and Mansonella perstans infections were significantly associated with higher prevalence of asymptomatic malaria parasitemia, although this difference depended on the geographic location of residence in Entebbe, Uganda. Yatich and others 28 also showed that hookworm coinfection was associated with increased prevalence of malaria infection among pregnant Ghanaian women, although women with Ascaris coinfection had an even greater likelihood of malaria infection.…”

Section: Concurrent Infectionmentioning

confidence: 99%

“…[18][19][20] Despite high levels of mixed malarial and soil-transmitted helminthic infections in subSaharan Africa, 21,22 only recently has there been renewed interest in the interactions between these infections during pregnancy. 23 Therefore, during a randomized controlled trial in southern Malawi evaluating intermittent preventive treatment regimens for malaria during pregnancy, we conducted a nested substudy investigating interactions between malaria and concurrent helminthic infection among primigravid and secundigravid women. 24 …”

Section: Introductionmentioning

confidence: 99%

Associations between Peripheral Plasmodium falciparum Malaria Parasitemia, Human Immunodeficiency Virus, and Concurrent Helminthic Infection among Pregnant Women in Malawi

Thigpen¹,

Filler²,

Kazembe³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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Approximately 2 billion persons worldwide are infected with schistosomiasis and soil-transmitted helminthes (STH), many in areas where endemic malaria transmission coexists. Few data exist on associations between these infections. Nested within a larger clinical trial, primigravid and secundigravid women provided blood samples for human immunodeficiency virus (HIV) testing and peripheral malaria films and stool and urine for evaluation of STH and Schistosoma spp. during their initial antenatal clinic visit. The most common parasitic infections were malaria (37.6%), S. haematobium (32.3%), and hookworm (14.4%); 14.2% of women were HIV-infected. S. haematobium infection was associated with lower malarial parasite densities (344 versus 557 parasites/μL blood; P < 0.05). In multivariate analysis, HIV and hookworm infection were independently associated with malaria infection (adjusted odds ratio = 1.9 and 95% confidence interval = 1.2–3.0 for HIV; adjusted odds ratio = 1.9 and 95% confidence interval = 1.03–3.5 for hookworm). Concurrent helminthic infection had both positive and negative effects on malaria parasitemia among pregnant women in Malawi.

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“…Se las ha asociado con anemia, trastornos del desarrollo y el crecimiento, desnutrición crónica y problemas de aprendizaje (1,3). Adicionalmente y dado que estos parásitos se distribuyen solapadamente junto con otras diversas infecciones en los países y áreas endémicas, (5) recientemente se ha propuesto que podría existir un impacto significativo en la potenciación de la carga de la enfermedad por la generación de co-morbilidades; por ejemplo a través de la sumatoria del riesgo o la intensidad de padecer anemia con especial impacto en mujeres embarazadas y niños de áreas altamente endémicas para más de una enfermedad tropical (6)(7)(8).…”

Section: Introductionunclassified

Conocimientos, actitudes y prácticas sobre las geohelmintiasis en una comunidad rural de Colombia

et al. 2010

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ResumenLas geohelmintiasis son un grupo de enfermedades desatendidas que afectan especialmente a la población infantil de países en vía de desarrollo. En este artículo se muestran los resultados de un trabajo cuyo objetivo fue explorar y describir los conocimientos, actitudes y prácticas sobre las geohelmintiasis en niños y padres de una población rural colombiana, como base para el diseño de un programa de educación en salud. Este es un estudio cualitativo, etnográfico, realizado en la población de La Virgen, (Colombia), cuya validez estuvo dada por la triangulación y su confiabilidad por la concordancia interpretativa, mediante la participación de varios investigadores. Se utilizaron las técnicas de encuesta, entrevistas, grupos de discusión, círculos de reflexividad y observación participante. Los datos de la encuesta se procesaron con el Programa EpiInfo VI y los cualitativos con el Atlas-ti 5.0.66. Aunque los participantes identificaron los factores de riesgo para las geohelmintiasis, no asociaron la infección con contaminación del suelo con los huevos o larvas de los helmintos, pero si con otras acciones, como el consumo de guayaba. Identificaron como manifestaciones clínicas el bruxismo, dolor abdominal, diarrea, y una entidad popularmente denominada "rebote de lombrices". Ellos emplean terapéuticas tradicionales como el paico (Chenopodium ambrosioides), pero también acostumbran a llevar los niños al médico cada seis meses para la desparasitación. Este estudio muestra que los factores de riesgo no deben ser exclusivamente considerados en términos de individuos o de determinantes sociales desarticulados (sexo, edad, nivel socioeconómico), sino dentro de un contexto sociocultural con un potencial explicativo fundamental que permite entender las condiciones bioculturales en que se instalan y prosperan estas infecciones.Palabras clave: conocimientos, actitudes, prácticas en salud, helmintiasis, escolares. KNOWLEDGE, ATTITUDES AND PRACTICES ABOUT THE SOIL TRANSMITTED HELMINTHS IN A RURAL COMMUNITY OF COLOMBIA AbstractGeohelminthiasis are a group of soil-transmitted parasitic diseases that specially affect children in the developing world. This article shows the results of a work which aimed to explore and to describe the

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Plasmodium falciparumand Helminth Coinfection in a Semiurban Population of Pregnant Women in Uganda

Abstract: Introduction-Helminth infections and malaria are widespread in the tropics. Recent studies suggest helminth infections may increase susceptibility to malaria. If confirmed, this could be particularly important during pregnancy-induced immunosuppression.

Cited by 82 publications

References 43 publications

Plasmodium falciparum and intestinal parasitic co-infections in HIV-infected patients in Benin City, Edo State, Nigeria

Plasmodium falciparum and intestinal parasitic co-infections in HIV-infected patients in Benin City, Edo State, Nigeria

Associations between Peripheral Plasmodium falciparum Malaria Parasitemia, Human Immunodeficiency Virus, and Concurrent Helminthic Infection among Pregnant Women in Malawi

Conocimientos, actitudes y prácticas sobre las geohelmintiasis en una comunidad rural de Colombia

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