<i>Plantago lanceolata</i> L. water extract induces transition of fibroblasts into myofibroblasts and increases tensile strength of healing skin wounds

Kováč, Ivan; Ďurkáč, Ján; Hollý, Martin; Jakubcova, Katarina; Peržeľová, Vlasta; Mučaji, Pavel; Švajdlenka, Emil; Sabol, František; Legáth, Jaroslav; Belák, J; Smetana, Karel; Gál, Péter

doi:10.1111/jphp.12316

Cited by 24 publications

(14 citation statements)

References 31 publications

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“…Wound healing may have occurred because of the regulation of collagen expression23 and an increase in the tensile strength of the wounds24. Healing activity depends on collagen formation and angiogenesis25.…”

Section: Discussionmentioning

confidence: 99%

In vivo Assessment of Antioxidant and Wound Healing Improvement of a New Schiff Base Derived Co (II) Complex in Rats

El-Ferjani

Ahmad

Dhiyaaldeen

et al. 2016

Sci Rep

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Co (II) complex (CMLA) was investigated to evaluate the rate of wound healing in rats. Animals were placed into four groups: gum acacia, Intrasite gel, 10 and 20 mg/ml of CMLA. Wounds were made on the dorsal neck area, then treated with Intrasite gel or CMLA; both of these treatments led to faster healing than with gum acacia. Histology of the wounds dressed with CMLA or Intrasite gel displayed a smaller scar width, required less time to heal and showed more collagen staining and fewer inflammatory cells in comparison to wounds dressed with the vehicle. Immunohistochemistry for Hsp70 and TGF-β showed greater staining intensity in the treated groups compared to the vehicle group. Bax staining was less intense in treated groups compared to the vehicle group, suggesting that CMLA and Intrasite gel provoked apoptosis, responsible for the development of granulation tissue into a scar. CD31 protein analysis showed that the treated groups enhanced angiogenesis and increased vascularization compared to the control group. Furthermore, a significant increase in the levels of GPx and SOD and a decrease in MDA were also observed in the treated groups. This results suggest that CMLA is a potentially promising agent for the wounds treatment.

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Section: Discussionmentioning

confidence: 99%

In vivo Assessment of Antioxidant and Wound Healing Improvement of a New Schiff Base Derived Co (II) Complex in Rats

El-Ferjani

Ahmad

Dhiyaaldeen

et al. 2016

Sci Rep

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“…Skin injuries such as wounds are defined as the disruption of skin integrity (Prisăcaru et al, ), which triggers a cascade of events that leads to a dynamic wound‐healing process in which a variety of extracellular matrix components act together as a very sophisticated sequence of events to re‐establish the integrity of the injured skin (Kováč et al, ; Martin, ). Wound healing occurs in five phases: inflammation, neovascularization, the formation of granulation tissue, re‐epithelisation and the formation of a new extracellular matrix, and tissue remodelling (Nevin & Rajamohan, ).…”

Section: Introductionmentioning

confidence: 99%

“…A number of experimental studies are therefore working on new approaches to skin wound healing, including the study of the potential of phytopharmacological methods (Ashcroft et al, ; Bedi & Shenefelt, ; Buchness, ; Eisenberg et al, ; Lania et al, ; S. B. Nayak, Isik, & Marshall, ; Schreml et al, ) to replace antibiotic therapy due to serious issues of bacterial resistance (S. B. Nayak et al, ). Phytotherapy in dermatology is the preferred option for patients over conventional therapy using synthetic medicines, particularly in terms of perceived side effects (Bedi & Shenefelt, ; Eisenberg et al, ) and has actually been proven to be effective (Buchness, ; Kováč et al, ). Medicinal plants have likewise been proven to have an effective impact on processes that play an important role in skin wound healing (Corazza, Borghi, Lauriola, & Virgili, ).…”

Section: Introductionmentioning

confidence: 99%

Vegetable butters and oils in skin wound healing: Scientific evidence for new opportunities in dermatology

Poljšak

Kreft

Glavač

2019

Phytotherapy Research

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The use of vegetable butters and oils shows promising results in the treatment of skin wounds, as they have an effective impact on the phases of the wound-healing process through their antimicrobial, anti-inflammatory, and antioxidative activities and by promoting cell proliferation, increasing collagen synthesis, stimulating dermal reconstruction, and repairing the skin's lipid barrier function.In this article, in vitro and in vivo studies of argan (Argania spinosa), avocado (Persea americana), black cumin (Nigella sativa), calophyllum (Calophyllum inophyllum), coconut (Cocos nucifera), cranberry (Vaccinium macrocarpon), grape (Vitis vinifera), green coffee (Coffea arabica), lentisk (Pistacia lentiscus), linseed (Linum usitatissimum), lucuma (Pouteria lucuma), mango (Mangifera indica), olive (Olea europaea), pomegranate (Punica granatum), pumpkin (Cucurbita pepo), rapeseed (Brassica napus), sea buckthorn (Hippophae rhamnoides), and sunflower (Helianthus annuus) oils were reviewed. In many cases, vegetable oils proved to be more effective than synthetic wound-healing compounds used as controls.The fatty-acid components of vegetable oils are assumed to play a major role in the wound-healing process, in particular polyunsaturated fatty acids such as linoleic acid.Evidence shows that oils with a higher linoleic to oleic acid ratio are more effective for lipid barrier repair. However, in depth studies are needed to gain knowledge about vegetable oils' effects on the skin and vice versa. KEYWORDSfatty acids, skinskin woundskin wound healingvegetable buttersvegetable oils

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“…Plantago is one of the most important genus within the Plantaginaceae family containing more than 200 species all around the world [ 1 ] Plantago lanceolata L. ( Ribwort plantain ) possesses various pharmacological properties for human health including antioxidant [ 2 ], anti-inflammatory [ 3 ], antineoplastic [ 4 ], hepatoprotective [ 5 ], immunoregulation, and neuroprotective properties, with an excellent and well-known safety profile. P. lanceolata has been also used in traditional medicine for its wound healing [ 6 ]. Its main active pharmaceutical ingredients belong to the group of phenylethanoid glycosides and iridoid glycosides [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Self-Nanoemulsifying Drug Delivery Systems Containing Plantago lanceolata—An Assessment of Their Antioxidant and Antiinflammatory Effects

et al. 2017

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The most important components of Plantago lanceolata L. leaves are catalpol, aucubin, and acteoside (=verbascoside). These bioactive compounds possess different pharmacological effects: anti-inflammatory, antioxidant, antineoplastic, and hepatoprotective. The aim of this study was to protect Plantago lanceolata extract from hydrolysis and to improve its antioxidant effect using self-nano-emulsifying drug delivery systems (SNEDDS). Eight SNEDDS compositions were prepared, and their physical properties, in vitro cytotoxicity, and in vivo AST/ALT values were investigated. MTT cell viability assay was performed on Caco-2 cells. The well-diluted samples (200 to 1000-fold dilutions) proved to be non-cytotoxic. The acute administration of PL-SNEDDS compositions resulted in minor changes in hepatic markers (AST, ALT), except for compositions 4 and 8 due to their high Transcutol contents (80%). The non-toxic compositions showed a significant increase in free radical scavenger activity measured by the DPPH test compared to the blank SNEDDS. An indirect dissolution test was performed, based on the result of the DPPH antioxidant assay; the dissolution profiles of Plantago lancolata extract were statistically different from each SNEDDS. The anti-inflammatory effect of PL-SNEDDS compositions was confirmed by the ear inflammation test. For the complete examination period, all compositions decreased ear edema as compared to the positive (untreated) control. It can be concluded that PL-SNEDDS compositions could be used to deliver active natural compounds in a stable, efficient, and safe manner.

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Plantago lanceolata L. water extract induces transition of fibroblasts into myofibroblasts and increases tensile strength of healing skin wounds

Abstract: We demonstrated that PL aqueous extract improves skin wound healing in rats. However, further research need to be performed to find optimal therapeutic concentration, and exact underlying mechanism prior obtained results may be introduced into the clinical practice.

Cited by 24 publications

References 31 publications

In vivo Assessment of Antioxidant and Wound Healing Improvement of a New Schiff Base Derived Co (II) Complex in Rats

In vivo Assessment of Antioxidant and Wound Healing Improvement of a New Schiff Base Derived Co (II) Complex in Rats

Vegetable butters and oils in skin wound healing: Scientific evidence for new opportunities in dermatology

Self-Nanoemulsifying Drug Delivery Systems Containing Plantago lanceolata—An Assessment of Their Antioxidant and Antiinflammatory Effects

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