Phialemonium obovatumKeratitis after Penetration Injury of the Cornea

Abstract

Phialemonium keratitis is a very rare case and we encountered a case of keratitis caused by Phialemonium obovatum (P. obovatum) after penetrating injury to the cornea. This is the first case report in the existing literature. A 54-year-old male was referred to us after a penetration injury, and prompt primary closure was performed. Two weeks after surgery, an epithelial defect and stromal melting were observed near the laceration site. P. obovatum was identified, and then identified again on repeated cultures. Subsequently, Natacin was administered every two hours. Amniotic membrane transplantation was performed due to a persistent epithelial defect and impending corneal perforation. Three weeks after amniotic membrane transplantation, the epithelial defect had completely healed, but the cornea had turned opaque. Six months after amniotic membrane transplantation, visual acuity was light perception only, and corneal thinning and diffuse corneal opacification remained opaque. Six months after amniotic membrane transplantation, visual acuity was light perception only, and corneal thinning and diffuse corneal opacification remained.

Cephalotheca sulfurea (Ascomycota, Sordariomycetes), a new fungal pathogen of the farmed rainbow trout Oncorhynchus mykiss

“…It is worth mentioning that species related to C. sulfurea are increasingly isolated from human clinical material and reported as agents of superficial as well as systemic infections. This is true for the majority of currently accepted Phialemonium and Cephalotheca species (Yaguchi et al 2006;De Hoog et al 2009;Hong, Ryoo & Chang 2012;Perdomo et al 2013;Lyskov a et al 2014;Lu et al 2015).…”

Novel cases of cutaneous phaeohyphomycosis by Alternaria alstromeriae, Epicoccum tritici and Phialemonium obovatum from North India

“…It was first reported as human pathogen in 1986, where Phialemonium obovatum was recovered from cutaneous as well as subcutaneous tissues of a 4.5 months old burned child 55 . This genus is reported to cause cutaneous infections in humans including lung infection, endophthalmitis, keratitis, arthritis, fungemia and peritonitis 56–59 …”

“…55 This genus is reported to cause cutaneous infections in humans including lung infection, endophthalmitis, keratitis, arthritis, fungemia and peritonitis. [56][57][58][59] Recently, a review providing the insights of superficial mycosis highlighted the association between occupation and superficial fungal infections. 60 Likewise, in our study, the occupation of the investigated patients (Case 1, student; Case 2, army personnel and Case 3, housemaker) is likely to have a role in the acquisition of cutaneous phaeohyphomycosis.…”

A rare case of Phialemonium obovatum keratitis

“…About three weeks after the amniotic membrane transplantation, the epithelium had completely healed but the cornea was opaque and the patient had hand motions only visual acuity. 12 …”