<i>Petasites hybridus</i>
            root (butterbur) is an effective preventive treatment for migraine

Lipton, Richard B.; Göbel, Hartmut; Einhäupl, Karl M.; Wilks, Kerri; Mauskop, Alexander

doi:10.1212/01.wnl.0000147290.68260.11

Cited by 223 publications

(144 citation statements)

References 19 publications

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“…Our meta-analysis of these two studies involving a 50-mg twice-daily dosage of butterbur 74,75 showed an odds ratio of 2.24 for a 50% reduction in frequency of migraine episodes (95% CI 0.64-7.81, p = 0.20) compared with placebo. For a 75-mg twice-daily dosage, assessed by one of these studies, 75 the odds ratio for reduction in migraine frequency was 2.16 (95% CI 1.06-4.38, p = 0.03).…”

Section: Vitamins Minerals and Herbal Agentsmentioning

confidence: 81%

Prophylaxis of migraine headache

Pringsheim

Davenport²,

Becker³

2010

Canadian Medical Association Journal

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Key points• The choice of prophylactic therapy for migraine is based on existing comorbidities, contraindications, reported efficacy, and adverse effect profiles.• Prophylaxis should be considered for patients whose migraines affect their quality of life despite appropriate symptomatic treatment, or who are at risk for medication overuse headache.• The period that successful migraine prophylaxis should be continued is not clear; patients should be followed up regularly to ensure that their medication is still beneficial.

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Section: Vitamins Minerals and Herbal Agentsmentioning

confidence: 81%

Prophylaxis of migraine headache

Pringsheim

Davenport²,

Becker³

2010

Canadian Medical Association Journal

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“…Some natural products, such as riboflavin, butterbur, and coenzyme Q10, appear effective for migraine prophylaxis. Due to its safety, magnesium is one option for pregnant women who require migraine prophylaxis [23][24][25][26]. Nevertheless, some preventive medications have been shown to be more efficacious than others in randomized, controlled trials.…”

Section: Overview Of the Market For Migraine Preventive Treatmentmentioning

confidence: 99%

Valproate semisodium ER for migraine and cluster headache prophylaxis

Lovell¹,

Marmura²

2010

Expert Opinion on Drug Metabolism & Toxicology

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“…The drugs for migraine prophylaxis are not completely effective or safe (3). The use of complementary preventive treatments has been growing worldwide that can be decrease the frequency and severity of migraine attacks with minimal side effects (5,6).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Feverfew Cultivated in Iran for the Prophylactic Treatment of Migraine: A Randomized Placebo-controlled Clinical Trial

Rafie

Namjoyan

Hassanzadeh

et al. 2015

Jundishapur J Nat Pharm Prod

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Background: One of the most common types of headache is migraine that often begins before 30 years age. The use of complementary preventive treatments has been growing worldwide that can be decrease the frequency and severity of migraine attacks with minimal side effects. Tanacetum parthenium L. (common name: feverfew) from Compositae family have traditionally been used as a febrifuge and remedy for migraine prophylaxis. Objectives: In present study, the effect of feverfew cultivated in Iran has been studied as a prophylactic treatment of migraine in a placebocontrolled clinical trial during 3 months. Patients and Methods: Criteria for inclusion were migraine without aura diagnosed after a careful medical history-taking according to the International Headache Society (IHS) criteria. The Migraine Disability Assessment Scores (MIDAS) questionnaire is quite a useful tool in clinical trial that the patients were recognized for migraine impact at the baseline and end of the study. Results: In the case group, after three months of treatment with feverfew, the MIDAS score was reduced to 19.18 ± 4.02. Compared to control group, the changes in intensity and frequency of migraine, in the treatment group was significant, at the end of the study (P < 0.05). Regarding the safety of feverfew extract the incidence of side effects in the treatment group was similar to placebo. Conclusions: In conclusion, the extract of feverfew showed a significant migraine prophylactic effect with no adverse events.

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Petasites hybridus root (butterbur) is an effective preventive treatment for migraine

Abstract: Petasites extract 75 mg bid is more effective than placebo and is well tolerated as a preventive therapy for migraine. Petasites 50 mg PO bid was not significantly more effective than placebo on the primary study endpoints.

Cited by 223 publications

References 19 publications

Prophylaxis of migraine headache

Prophylaxis of migraine headache

Valproate semisodium ER for migraine and cluster headache prophylaxis

The Effect of Feverfew Cultivated in Iran for the Prophylactic Treatment of Migraine: A Randomized Placebo-controlled Clinical Trial

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