Peroxisome proliferator‐activated receptor (PPAR) delta genetic polymorphism and its association with insulin resistance index and fasting plasma glucose concentrations in Chinese subjects

Abstract

The PPARD-87T/C polymorphism is associated with higher fasting plasma glucose concentrations in both NGT and diabetic subjects, largely due to impaired insulin sensitivity.

Protective role of +294 T/C (rs2016520) polymorphism of PPARD in Mexican patients with colorectal cancer

“…PPARD is expressed in diverse tissues with very high expression levels in the gastrointestinal tract (Park et al, 2001;Barak et al, 2002;Lee et al, 2003;Gupta et al, 2004;Harman et al, 2004;Foreman et al, 2011;Peters et al, 2011;Yang et al, 2006Yang et al, , 2008Yang et al, , 2010Yang et al, , 2011Fucci et al, 2012;Wang et al, 2006Wang et al, , 2014Zuo et al, 2009Zuo et al, , 2014. Several PPARD polymorphisms have been involved in regulation of lipid and glucose metabolism and in disorders related to these processes, including cardiovascular disease (Skogsberg et al, 2003a,b), atherosclerosis (Chen et al, 2004), insulin resistance (Hu et al, 2006), diabetes (Villegas et al, 2011), and recently in cancer (Ticha et al, 2013;Yang et al, 2014). Notably, the PPARD +294 T/C (rs2016520) polymorphism, which is located in exon 4 at 87 nucleotides upstream of the start codon (5' untranslated region), influences the binding of Sp1 transcription factor resulting in higher transcriptional activity when the rare C allele is present (Skogsberg et al, 2003a).…”

Retinoid X Receptor Heterodimer Variants and Cardiovascular Risk Factors

“…The C allele was associated with higher transcriptional activity 116) . This C allele of c.-87T C polymorphism was also shown to be associated with unfavorable phenotypes, such as low HDL-C in women 117) , and increased fasting plasma glucose 118,119) . On the other hand, from the analysis of 15 PPAR polymorphisms among subjects without type 2 diabetes or hereditary dyslipidemia in French-Canadians, only the C allele of c.-87T C showed an association with favorable phenotypes, such as a lower risk of metabolic syndrome 120) , and lower BMI, the latter of which was reported in another Caucasian group 121) .…”

Regulation of Skeletal Muscle Physiology and Metabolism by Peroxisome Proliferator-Activated Receptor δ

“…Because PPAR␦ is an important regulator of genes involved in lipid and glucose metabolism, one might expect polymorphisms in PPARD to be associated with the metabolic syndrome, type 2 diabetes, obesity, and/or cardiovascular disease. Several association studies on the role of PPARD polymorphisms in relation to metabolic dysfunction and risk for diabetes and cardiovascular disease have been published (Skogsberg et al, 2003a,b;Shin et al, 2004;Gouni-Berthold et al, 2005;Vä nttinen et al, 2005;Aberle et al, 2006a,b;Andrulionyte et al, 2006;Hu et al, 2006;Grarup et al, 2007;Hautala et al, 2007;Robitaille et al, 2007;Stefan et al, 2007;Lagou et al, 2008;Sá ez et al, 2008;Thamer et al, 2008). More than 16 SNPs in PPARD have been analyzed thus far, and the majority of these relatively large association studies have investigated a polymorphism in exon 4, rs2016520, located 87 base pairs upstream of the translational start site.…”

“…An association of the minor C allele of the same rs2016520 polymorphism in exon 4 discussed in relation to lipoprotein regulation with a higher percentage of body fat in 376 nondiabetic Chinese subjects has been detected (Hu et al, 2006). In line with this finding is the report regarding a polymorphism located in exon 7 (rs2076167) that showed an odds ratio of 1.43 with respect to obesity in a case-control study comprising 725 obese subjects (BMI Ͼ 30) and 1228 nonobese control subjects (Sá ez et al, 2008).…”