<i>Peroral</i>Route:  An Opportunity for Protein and Peptide Drug Delivery

Sood, Anurag; Panchagnula, Ramesh

doi:10.1021/cr000700m

Cited by 191 publications

(63 citation statements)

References 309 publications

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“…Many researchers have attempted to administer insulin orally since its discovery in 1922 [169]. However, the oral bioavailability of insulin is severely hampered by its inherent instability in the gastrointestinal (GI) tract and its low permeability across biological membranes in the intestine [170,171]. The concept of closed loop control of glucose, in which continuous glucose sensing is coupled to a fully automated insulin delivery device, without human input, has been an attractive idea for diabetes management [170][171][172].…”

Section: Responsive Polymer-inorganic Hybrid Nanogels In Drug Deliverymentioning

confidence: 99%

“…However, the oral bioavailability of insulin is severely hampered by its inherent instability in the gastrointestinal (GI) tract and its low permeability across biological membranes in the intestine [170,171]. The concept of closed loop control of glucose, in which continuous glucose sensing is coupled to a fully automated insulin delivery device, without human input, has been an attractive idea for diabetes management [170][171][172]. Considering the attractive multifunctional capabilities of responsive polymer-inorganic hybrid nanogels, we think that it is possible to design a single hybrid nanogel that may simultaneously act as a monitoring system (glucose sensor) to evaluate an input (glucose levels) and a triggerable delivery system to predictably control the output (insulin infusion rate).…”

Section: Responsive Polymer-inorganic Hybrid Nanogels In Drug Deliverymentioning

confidence: 99%

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Responsive Polymer‐Inorganic Hybrid Nanogels for Optical Sensing, Imaging, and Drug Delivery

Wu¹,

Zhou²

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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Responsive hybrid nanogels, comprising inorganic nanoparticles (NPs) immobilized in a polymer nanogel, have recently attracted intensive interest. While inorganic NPs exhibit size-, shape-, and interdistance-dependent optical, magnetic, electronic, and catalytic properties, responsive polymer nanogels can undergo a volume phase transition in response to external stimuli, such as temperature, pH, glucose level, light, and other stimulus, to modify the physicochemical environment of the inorganic NPs immobilized inside. The controllable properties of the responsive hybrid nanogels can offer the possibilities for external switching and manipulation when applied to a diverse range of applications. In this Chapter we provide an analysis of recent advances on the responsive polymer-inorganic hybrid nanogels. The Chapter consists of three major parts: the fundamental theory, synthesis, and applications of the polymer-inorganic hybrid nanogels in optical sensing, diagnostic imaging, and drug delivery.

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Section: Responsive Polymer-inorganic Hybrid Nanogels In Drug Deliverymentioning

confidence: 99%

Section: Responsive Polymer-inorganic Hybrid Nanogels In Drug Deliverymentioning

confidence: 99%

Responsive Polymer‐Inorganic Hybrid Nanogels for Optical Sensing, Imaging, and Drug Delivery

Wu¹,

Zhou²

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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“…Such drug formulations rely on their ability to protect P/P drugs from degradative gastrointestinal enzymatic attack by delivering the drug to the most favorable site for absorption (e.g., the large intestine). In developing such DDS, the concepts of enzyme inhibitors, absorption enhancers, and/or bioadhesive polymers can also be considered in order to increase the efficiency of P/P delivery to absorptive mucosa that, in turn, increases the drug absorption into the systemic circulation [21].…”

Section: Drug Delivery Devicesmentioning

confidence: 99%

Nanotechnology advances in controlled drug delivery systems

Kiparissides

Kammona

2008

Phys. Status Solidi (c)

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Nanotechnology advances in drug delivery deal with the development of synthetic nanometer sized targeted delivery systems for therapeutic agents of increased complexity, and biologically active drug products. Therapeutic systems in this class are up to a million times larger than classical drugs like aspirin. Being larger there is more scope for diversity and complexity, which makes their protection much more challenging and their delivery more difficult. Their increased complexity however, gives these systems the unique power to tackle more challenging diseases. Targeted delivery systems can have multiple functions, a key one being their ability to recognize specific molecules which can be located either on the membrane of target cells, or in specific compartments within the cell. A challenging objective of targeted drug delivery is the development of innovative multidisciplinary approaches for the design, synthesis and functionalization of novel nanocarriers for targeted delivery of protein/peptide (P/P) drugs via oral, pulmonary and nasal administration routes as well as the fabrication of “smart” miniaturized drug delivery devices able to release a variety of drugs on demand. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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“…42 Additionally, the delivery of both proteins and peptides can be problematic unless specially facilitated, 43 especially when treated as oral drugs. 44 To summarize, people have started to look for other alternatives with high comparability and better performance compared with the skeletons coming from native proteins to overcome these challenges.…”

mentioning

confidence: 99%

Protein/peptide secondary structural mimics: design, characterization, and modulation of protein–protein interactions

et al. 2016

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Protein-protein interactions (PPIs) play a critical role in many essential biological processes, and numerous diseases result from malfunctioning PPIs. The modulation of undesirable PPIs via synthetic chemical molecules has long been considered of medical importance, but still remains challenging. Thanks to the development of synthetic chemistry, chemists can synthesize protein/peptide secondary structure mimics to modulate the specific PPIs. This review discusses general aspects of novel artificial peptide secondary structure mimics for the modulation of PPIs, their therapeutic applications and future prospects.

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PeroralRoute: An Opportunity for Protein and Peptide Drug Delivery

Cited by 191 publications

References 309 publications

Responsive Polymer‐Inorganic Hybrid Nanogels for Optical Sensing, Imaging, and Drug Delivery

Responsive Polymer‐Inorganic Hybrid Nanogels for Optical Sensing, Imaging, and Drug Delivery

Nanotechnology advances in controlled drug delivery systems

Protein/peptide secondary structural mimics: design, characterization, and modulation of protein–protein interactions

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