<i>Pasteurella multocida</i>Infections with Unusual Modes of Transmission from Animals to Humans: A Study of 79 Cases with 34 Nonbite Transmissions

Kannangara, Don Walter; Pandya, Dhyanesh; Patel, Parth

doi:10.1089/vbz.2019.2558

Cited by 26 publications

(32 citation statements)

References 160 publications

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“…While penicillins are the mainstay of therapy, due to our patient's beta-lactam allergy, he was started on meropenem and had a positive response. In general, P. multocida bacteremia carries a high fatality rate of about 30% despite aggressive treatment [7]. Despite evidence of life-threatening septic shock, our patient did remarkably well considering the circumstances.…”

Section: Discussionmentioning

confidence: 69%

Pasteurella Multocida Bacteremia and Septic Arthritis in a Patient With Non-Bite Animal Exposure

Leonhardt¹,

Pervez²,

Tang³

2021

Cureus

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Pasteurella multocida (P. multocida) is a gram-negative, facultative anaerobe, and it is most commonly found in the oropharynx of healthy domestic animals, especially cats and dogs. P. multocida is classified as an opportunistic pathogen, infecting individuals only through direct contact via local trauma caused by animal bites or scratches. More serious infections, while rare, are typically associated with immunocompromised states, known pre-existing cavitary lung pathology, or malignancy. In this report, we present a case of P. multocida infection without known trauma, which had likely spread via respiratory droplets causing bacteremia, septic shock, and subsequent septic arthritis of the left knee.

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Section: Discussionmentioning

confidence: 69%

Pasteurella Multocida Bacteremia and Septic Arthritis in a Patient With Non-Bite Animal Exposure

Leonhardt¹,

Pervez²,

Tang³

2021

Cureus

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“…As previously described, no exposure to animals was noted for 90% of the deaths among invasive cases (Körmöndi et al, 2019;Nollet et al, 2016). A weaker bacterial inoculum and different types of exposure to the bacteria could be involved in the pathogenesis of non-bite-related cases which often occur in immunocompromised patients (Chatelier et al, 2020;Fayyaz, 2018;Kannangara et al, 2020;Weber et al, 1984). According to two series, advanced age and some underlying conditions (neoplasia, chronic liver disease, cardiovascular disease, and diabetes mellitus) seem to be the risk factors for invasive pasteurellosis (Körmöndi et al, 2019;Nollet et al, 2016).…”

Section: Discussionmentioning

confidence: 79%

“…Invasive infections do not result from worsening of local conditions and their management is not as straightforward as local infections. First, injury caused by an animal is usually absent (Kannangara et al, 2020;Körmöndi et al, 2019;Nollet et al, 2016). In this study, an injuryfree exposure to an animal was described in the medical history in about one-third of invasive cases.…”

Section: Discussionmentioning

confidence: 86%

“…Since deaths may occur despite optimal medical management, some authors advise the use of preventive measures for immunocompromised patients (Christenson et al, 2015;Kannangara et al, 2020;Körmöndi et al, 2019). Although pets undoubtedly have a positive psychological impact on many people, it might be prudent for elderly individuals and/or patients with cancer to avoid contact with them (Kannangara et al, 2020;Körmöndi et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Sometimes, more severe complications occur such as septic arthritis (SA), osteomyelitis, or extensive cellulitis (Giordano et al, 2015;Körmöndi et al, 2019;Nseir et al, 2009;Weber et al, 1984). More rarely, these bacteria can lead to invasive infections confirmed by a positive culture of any sterile body fluid, particularly among older patients with underlying diseases (Chatelier et al, 2020;Christenson et al, 2015;Escande and Lion, 1993;Giordano et al, 2015;Kannangara et al, 2020;Körmöndi et al, 2019;Kumar et al, 1990;Nollet et al, 2016;Raffi et al, 1987;Weber et al, 1984). Mortality rates of Pasteurella invasive infections may be as high as 30% of cases (Chatelier et al, 2020;Kumar et al, 1990;Raffi et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

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Prognostic factors of Pasteurella infections: a single-center retrospective cohort study over a 14-year period (2005-2018)

Dernoncourt

Lacroix

Duhaut

et al. 2022

International Journal of Infectious Diseases

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Pasteurella species bloodstream infections in Queensland, Australia, 2000–2019

Laupland

Stewart

Edwards

et al. 2022

Eur J Clin Microbiol Infect Dis

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Pasteurella species are infrequent but potentially severe causes of bloodstream infection (BSI). The objective of this study was to determine the incidence, risk factors, and outcomes of Pasteurella species BSI in a large Australian population. Retrospective, laboratory-based surveillance was conducted in Queensland, Australia (population ≈ 5 million) during 2000–2019, and clinical and outcome information was established by linkage to state hospital admissions and vital statistics databases. During more than 86 million person-years of surveillance, 272 incident Pasteurella species BSI occurred for an overall age- and sex-standardized annual incidence of 3.3 per million residents. The incidence of Pasteurella species BSI was highest in recent years and older individuals were at greatest risk. The median (interquartile range) Charlson Comorbidity Index was 2 (0–4) with scores of zero, 1, 2, and 3 + observed in 81 (30%), 37 (14%), 44 (16%), and 110 (40%) of cases. The 30-day all-cause case fatality was 9% (24/272) and patients who died had more comorbidities and were less likely to have community-associated disease. Although Pasteurella species are infrequent causes of BSI, older individuals and those with comorbidities are at highest risk. The burden of this disease may be expected to increase with an aging and more comorbid population.

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Pasteurella multocidaInfections with Unusual Modes of Transmission from Animals to Humans: A Study of 79 Cases with 34 Nonbite Transmissions

Cited by 26 publications

References 160 publications

Pasteurella Multocida Bacteremia and Septic Arthritis in a Patient With Non-Bite Animal Exposure

Pasteurella Multocida Bacteremia and Septic Arthritis in a Patient With Non-Bite Animal Exposure

Prognostic factors of Pasteurella infections: a single-center retrospective cohort study over a 14-year period (2005-2018)

Pasteurella species bloodstream infections in Queensland, Australia, 2000–2019

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