“…Bacterial flagellins show strong adjuvant effects when delivered to mammalian hosts, via mucosal or parenteral routes, either in the form of purified protein admixed with target antigens or as hybrid proteins genetically fused to the antigen (4,8,22,23,36). Our results demonstrate that derivatives of S. Typhimurium strain SL3261, proficient in the expression of both FliCI and FljB, and strain LDV321, in which the expression of both flagellar phases is specifically blocked (31), did not differ significantly in their immunogenicity as vaccine vectors for passenger antigens regarding activation of either Stx2-specific systemic or mucosal antibody responses in orally vaccinated mice.…”