<i>Parachlorella beyerinckii</i> accelerates lead excretion in mice

Uchikawa, Takuya; Ueno, Takeyuki; Hasegawa, Takashi; Maruyama, Isao; Kumamoto, Shoichiro; Ando, Yumiko

doi:10.1177/0748233709346759

Cited by 8 publications

(10 citation statements)

References 21 publications

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“…Chlorella is a unicellular green algae that has been shown to facilitate mercury and lead excretion in mice . Uchikawa et al .…”

Section: Is There a Role For Nutrition In Detoxification?mentioning

confidence: 99%

Detox diets for toxin elimination and weight management: a critical review of the evidence

Klein

Kiat²

2014

J Human Nutrition Diet

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Detox diets are popular dieting strategies that claim to facilitate toxin elimination and weight loss, thereby promoting health and well-being. The present review examines whether detox diets are necessary, what they involve, whether they are effective and whether they present any dangers. Although the detox industry is booming, there is very little clinical evidence to support the use of these diets. A handful of clinical studies have shown that commercial detox diets enhance liver detoxification and eliminate persistent organic pollutants from the body, although these studies are hampered by flawed methodologies and small sample sizes. There is preliminary evidence to suggest that certain foods such as coriander, nori and olestra have detoxification properties, although the majority of these studies have been performed in animals. To the best of our knowledge, no randomised controlled trials have been conducted to assess the effectiveness of commercial detox diets in humans. This is an area that deserves attention so that consumers can be informed of the potential benefits and risks of detox programmes.

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“…Chlorella is a unicellular green algae that has been shown to facilitate mercury and lead excretion in mice . Uchikawa et al .…”

Section: Is There a Role For Nutrition In Detoxification?mentioning

confidence: 99%

Detox diets for toxin elimination and weight management: a critical review of the evidence

Klein

Kiat²

2014

J Human Nutrition Diet

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“…It has been eaten as a nutritional food since 1964 in Japan because it contains abundant nutritional components such as proteins, vitamins, minerals, and dietary fibers. It has also previously been reported to be useful in detoxifying dioxins, cadmium, and lead in animal experiments (Morita et al, 2001;Nagano et al, 1983;Uchikawa et al, 2009).…”

Section: Introductionmentioning

confidence: 91%

Chlorella suppresses methylmercury transfer to the fetus in pregnant mice

Uchikawa¹,

Maruyama²,

Kumamoto³

et al. 2011

J. Toxicol. Sci.

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-To investigate the effects of chlorella on methylmercury (MeHg) transfer to the fetus during pregnancy, female C57BL/6N mice (aged 10 weeks) were housed for 7 to 8 weeks, from 4 weeks before mating to birth, with diets containing 0% or 10% chlorella powder (CP) and MeHg-containing drinking water (2 μg Hg/ml). The consumption volume of the MeHg-containing water was limited to 15 ml/mouse/week throughout the experiment. Distilled water and a basal diet (0% CP) was given to control mice. Except for the mating period, during the 5 th week, mice were housed individually until parturition. Two neonates were randomly selected from each mother mouse within 24 hr after parturition for Hg analysis of the blood, brain, liver, and kidneys. Mother mice were sacrificed on the same day as neonates to obtain tissue samples for Hg analysis. The blood and brain Hg levels of both neonates and mothers in the CP diet group were significantly lower than those in the basal diet group. Although the hepatic and renal Hg levels were not significant in mothers between the two dietary groups, in neonates, the CP diet group showed significantly lower Hg levels in these tissues than the basal diet group. The results obtained here revealed that continuous CP intake suppressed MeHg transfer to the fetus, in addition to effective suppressing MeHg accumulation in brains of the mothers.

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“…Since Chlorella is known to have an ability to adsorb several heavy metals (Sandau et al, 1996), the dietary components of BP may adsorb a part of MeHg in the gastrointestinal tract. In fact, 80% of lead was adsorbed on dBP in 200 ppm of lead solution (Uchikawa et al, 2009). The adsorbed portion of MeHg may appear in the feces without intestinal absorption.…”

Section: Parachlorella Beyerinckiimentioning

confidence: 99%

The influence of Parachlorella beyerinckii CK-5 on the absorption and excretion of methylmercury (MeHg) in mice

Uchikawa¹,

Yasutake

Kumamoto³

et al. 2010

J. Toxicol. Sci.

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-Chlorella (Parachlorella beyerinckiiChlorella vulgaris CK-5, is a unicellular green algae that has for many years been used as a nutritional supplement. In order Chlorella, we examined the absorption and excretion of MeHg in mice. Female C57BL/6N mice were randomly divided into three groups 5 mg (4 mg Hg)/kg body weight with or without 100 mg/mouse of P. beyerinckii powder (BP), and were assigned to either a MeHg group or MeHg + BP group, accordingly. Twenty-four hr after oral administration, feces and urine were collected, and blood, liver, and kidney samples were obtained. Total mercury contents in the samples obtained were determined using an atomic absorption method. The amounts of Hg excreted in feces and urine of the MeHg + BP group were increased nearly 1.9 and 2.2-fold compared -ent between two groups. These results suggest that the intake of BP may induce the excretion of Hg both in feces and urine, although it does not affect MeHg absorption from the gastrointestinal tract. The effect of BP on the tissue mercury accumulation may become evident in a long-term experiment.Parachlorella beyerinckii, MeHg, Chlorella

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Parachlorella beyerinckii accelerates lead excretion in mice

Cited by 8 publications

References 21 publications

Detox diets for toxin elimination and weight management: a critical review of the evidence

Detox diets for toxin elimination and weight management: a critical review of the evidence

Chlorella suppresses methylmercury transfer to the fetus in pregnant mice

The influence of Parachlorella beyerinckii CK-5 on the absorption and excretion of methylmercury (MeHg) in mice

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