Pancratium canariense as an Important Source of Amaryllidaceae Alkaloids

Abstract

Four new alkaloids (1-4) have been isolated from a methanolic extract of bulbs of Pancratium canariense, together with 12 known alkaloids (5-16). The structures of the new alkaloids were determined by extensive 1D and 2D NMR spectroscopic studies and X-ray diffraction.

Galanthamine production by Leucojum aestivumL. shoot culture in a modified bubble column bioreactor with internal sections

“…The SD (n = 2) in all cases were less than 15%. [29] b) [24] c) [28] d) [37] e) [38] f) [39] Investigation of the uptake of the carbon source of the nutrient medium showed that the degree of utilization of the sugars from L. aestivum line 80 shoot culture decreased with decreasing the temperature of cultivation from 26 • C to 18 • C (from 44.9% to 22.0%, Fig. 4A).…”

Amaryllidaceae Alkaloids from Lycoris radiata

“…As part of our search for novel and bioactive compounds, we isolated three new Amaryllidaceae alkaloids, 5,6-dehydrodihydrolycorine (1), 6b-acetoxycrinamine (2), and (þ)-8-O-acetylhomolycorine a-N-oxide (3), together with eleven known analogs from bulbs of Lycoris radiata, a Chinese folk medicine famous for the treatment of poliomyelitis [15]. The new structures were elucidated by means of spectroscopic methods, and the known compounds were identified as 6-hydroxycrinamine (4) [16], homolycorine (5) [17], dihydrolycorine (6) [18], lycorine (7) [18], 7-oxodihydrolycorine (8) [19], (þ)-hippeastrine (9) [20], 2a-hydroxy-6-O-methoxyloduline (10) [21], galanthamine (11) [22], 7-deoxynarciclasine (12) [23], pancratinine C (13) [24], and 5,6-dihydrobicolorine (14) [25]. In addition, compounds 1 -3 were evaluated for their cytotoxic activities against five human cancer cell lines.…”

Anti-TMV Effects of Amaryllidaceae Alkaloids Isolated from the Bulbs of Lycoris radiata and Lycoricidine Derivatives

“…Structures of the compounds were identified by comparison of their MS and NMR data with those reported in the literature. They were respectively sanguinine ( 1 ) [15], 11-hydroxyvittatine ( 2 ) [16], lycoramine ( 3 ) [17], pancratinine C ( 4 ) [18], homolycorine ( 5 ) [19], hippeastrine ( 6 ) [20], O -demethylhomolycorine N-oxide ( 7 ) [21], zephyranthine ( 8 ) [22], O -methyllycorenine N-oxide ( 9 ) [23], lycoranine C ( 10 ) [24], tazettine ( 11 ) [25], lycorine ( 12 ) [26], 9- O -demethylhomolycorine ( 13 ) [27], homolycorine N-oxide ( 14 ) [23], galanthamine ( 15 ) [28].

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