Panax notoginseng Attenuates Experimental Colitis in the Azoxymethane/Dextran Sulfate Sodium Mouse Model

Abstract

Patients suffering from inflammatory bowel disease are at a high risk of developing colorectal cancer. To assess the anti-cancer potential of botanicals, in this study, we evaluated the effects of Panax notoginseng on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis. One week after A/J mice received AOM, the animals received DSS for 8 days, or were supplemented with P. notoginseng extract, at 30 or 90 mg/kg. DSS-induced colitis was scored with the disease activity index (DAI). The severity of the inflammatory lesions was evaluated by a colon tissue histological assessment. The expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were also explored. We observed that the effects of P. notoginseng on the reduction of colon inflammation, expressed in DAI score, were in a dose-related manner (P < 0.01). P. notoginseng inhibited the reduction of the colon length and the loss of bodyweight in dose-related manner (all P < 0.05). The histological assessment of the colitis and inflammatory related immunohistochemical data also supported the pharmacological observations. Our data suggest that P. notoginseng is a promising candidate in preventing and treating colitis and inflammation-associated colon carcinogenesis.

American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice

“…Previously, we evaluated the effects of another herb in the ginseng family, notoginseng, on experimental colitis for up to 14 days. We reported that notoginseng attenuated the acute colitis [34] comparable to what was observed using AG in this study. Although the ginseng saponin profiles are different between AG and notoginseng, the two botanicals also share a number of common ginsenosides.…”

Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium–Induced Colitis

“…After the mice were killed under anesthesia, the colons were immediately removed and fixed in 10% buffered formalin, paraffin-embedded, sectioned, and stained with H&E. Histologic score of H&E-stained specimens of the colon was determined by two pathologists in a blinded fashion. Histologic sections were scored using a validated scoring system as described previously (Williams et al, 2001;Wen et al, 2014).…”

Coevolution between Cancer Activities and Food Structure of Human Being from Southwest China

“…Yunnan is the Chinese largest producer of Panax notoginseng , which accounts for 97% of the production of China, and more than 400 products were made from it by 1302 companies in China. P. notoginseng is a promising candidate in preventing and treating inflammation-associated colon carcinogenesis [ 78 ]. Macroporous resin from the leaves of P. notoginseng is enriched with low polarity PPD group saponins of 85% ethanol fraction, which is a new alternative source of anticancer saponins [ 79 ].…”