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            -values and reproductive health: what can clinical researchers learn from the American Statistical Association?

Farland, Leslie V.; Correia, Katharine F.; Wise, Lauren A.; Williams, Paige L.; Ginsburg, Elizabeth S.; Missmer, Stacey A.

doi:10.1093/humrep/dew192

Cited by 41 publications

(26 citation statements)

References 8 publications

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“…In the present study, we report on and make inferences based on a large number of statistical tests at the 0.05 significance level. As multiple comparisons increase the risk of type-1 error, and significant changes noted with such analyses might be attributed to chance or random variation, the inferences, particularly those that are on the borderline of statistical significance at the nominated 5% level, should be viewed with considerable caution (Farland et al, 2016;Walters, 2016). Limited sample size and lack of automated system for annotation are limitations of the current study.…”

Section: )mentioning

confidence: 90%

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Duration of blastulation may be associated with ongoing pregnancy rate in single euploid blastocyst transfer cycles

Mümüşoğlu

Ozbek²,

Sökmensüer

et al. 2017

Reproductive BioMedicine Online

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Not all euploid embryos implant, necessitating additional tools to select viable blastocysts in preimplantation genetic screening cycles. In this retrospective cohort study, 129 consecutive patients who underwent 129 single euploid blastocyst transfers in cryopreserved embryo transfer cycles were included. All embryos were individually cultured in a time-lapse incubator from intracytoplasmic sperm injection up to trophoectoderm biopsy. Twenty-three time-lapse morphokinetic variables were tested among patients with (n = 68) or without (n = 61) ongoing pregnancy. All 23 time-lapse morphokinetic variables, apart from duration of blastulation (tB-tSB), were comparable between patients with or without ongoing pregnancy. Duration of blastulation was significantly shorter in patients with ongoing pregnancy (8.1 ± 3.2 versus 9.5 ± 3.4 h; P = 0.014); shorter duration of blastulation remained an independent predictor for ongoing pregnancy, when tested by logistic regression analysis (OR 0.81; 95% CI 0.70 to 0.93). One important limitation of this study, and a reason for caution, is the use of multiple comparisons, which can lead to differences at the 0.05 level simply by chance or random variation. Nonetheless, the study suggests that when more than one euploid blastocyst is available, priority might be given to those with a shorter duration of blastulation.

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Section: )mentioning

confidence: 90%

“…As multiple testing increases the risk of type-1 error, significant changes noted at the 0.05 level might be attributed to chance or random variation, and one should be cautious about the inferences, particularly those that are on the borderline of statistical significance at the nominated 5% level (Farland et al, 2016;Walters, 2016).…”

Section: Discussionmentioning

confidence: 99%

Duration of blastulation may be associated with ongoing pregnancy rate in single euploid blastocyst transfer cycles

Mümüşoğlu

Ozbek²,

Sökmensüer

et al. 2017

Reproductive BioMedicine Online

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“…Such studies as Jarrin et al (2015) and Galeev et al (2002) raise a question whether all statistically significant differences are clinically relevant? Whether, in fact, the small differences in the values of HRV measures are statistically different because of the mass effect, i.e., large sample sizes influencing p -value (Farland et al, 2016). Gasior et al (2015) recorded a resting ECG in 158 boys and 173 girls in age between 6 and 13 years old and selected 5-min segments for the time and spectral HRV analysis.…”

Section: Discussionmentioning

confidence: 99%

Measures of Heart Rate Variability in 24-h ECGs Depend on Age but Not Gender of Healthy Children

et al. 2017

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Many methods computing heart rate variability (HRV) have been applied in studies in children. Not all of these methods have a comprehensive physiological interpretation, and not all of studies are in agreement with the Task Force Standards on HRV from 1996, and the New Joint Position Statement on the advances of HRV from 2015. The study aim was to analyse HRV in the 24-h ECGs of healthy children by the Poincare plots and Lomb-Scargle periodograms, and to follow proper HRV recommendations. Additionally, we investigated the associations between age, children's sex and measured HRV indices. One hundred healthy children, aged 3–18 underwent 24-h ECG Holter monitoring. HRV was analyzed by the Poincaré plots and spectral by Lomb-Scargle periodograms of RR intervals. The Mann-Whitney test was used to compare sex differences in HRV, the van Elteren's test was used to correct for the age-gender interaction, and non-parametric Spearman correlation was applied to analyse the association between age and HRV indices. None of the HRV measures differed significantly between boys and girls. None of the HRV indices was modified by the age-gender interaction. There were statistically significant associations of age with measures of ultra-low (rho = 0.42; p < 0.0001), very low (rho = 0.35; p = 00004) and low (rho = 0.30; p = 0.0028) frequency powers, the ratio of the low to high frequency power (rho = 0.38; p = 0.0001), indices of long-term (SD2; rho = 0.37; p = 0.0002) and total (SDNN; rho = 0.33; p = 0.0008) HRV, and the contribution of the long-term HRV to total HRV (CL; rho = 0.32; p = 0.0012). In general, HRV parameters derived from the analyses of Poincaré plots and Lomb-Scargle periodograms appear not to be affected by gender, however, most of them increase with age in the 24-h ECG recordings in healthy children.

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“…However, another simple way would be to present predicted probabilities obtained from a logistic regression model (rather than an odds ratio) and, if desired, use these predicted probabilities to estimate risk ratios [53]. Finally, while the utility of the p-value in biomedical research has been argued for many years [54, 55] a thorough discussion of their use in reproductive epidemiology has recently been described by Farland et al [56]. The pitfalls of relying on p-values remain a concern for ART studies.…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic Approaches for Studying Assisted Reproductive Technologies: Design, Methods, Analysis, and Interpretation

Messerlian

Gaskins

2017

Curr Epidemiol Rep

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Purpose While considerable progress has been made since the advent of assisted reproductive technology (ART), the field remains a complex and challenging one for clinicians and researchers alike. This review discusses some of the most salient issues pertaining to the study of ART and whenever possible suggestions on how to address them. Recent Findings More than 5 million babies have been born through ART to date, representing up to 4% of all births worldwide. While technologies continue to evolve and demand for treatment grows, it is more important than ever to conduct rigorous and timely research to help guide clinical practice that is safe and effective, and that minimizes potential short- and long-term adverse outcomes to mother and child. Summary ART research will require exceedingly more sophisticated research methods, designs, and analyses that are rooted in a reproductive epidemiological framework in order to improve future research and ultimately promote better outcomes for all subfertile couples and their children.

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P -values and reproductive health: what can clinical researchers learn from the American Statistical Association?

Cited by 41 publications

References 8 publications

Duration of blastulation may be associated with ongoing pregnancy rate in single euploid blastocyst transfer cycles

Duration of blastulation may be associated with ongoing pregnancy rate in single euploid blastocyst transfer cycles

Measures of Heart Rate Variability in 24-h ECGs Depend on Age but Not Gender of Healthy Children

Epidemiologic Approaches for Studying Assisted Reproductive Technologies: Design, Methods, Analysis, and Interpretation

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