Oxygen Toxicity. Effects of Oxygen Breathing at Increased Ambient Pressure Upon pCO₂ of Subcutaneous Gas Depots in Men, Dogs, Rabbits and Cats

Changes in cardiac and respiratory function, and in blood carbon dioxide pressure and pH, in cats exposed to oxygen under high pressure

“…Bean (1945) has stated that CO2 pressure of arterial blood is not necessarily an indication of that obtaining in the tissues. The values obtained in the present experiments from analyses of arterial and mixed venous blood agree well with those for arterial and jugular-vein blood of Lambertsen and his colleagues, who have discussed in great detail the relation between arterial and venous blood CO2 pressures and 'central' C02 pressure (Lambersten, Kough, Cooper, Emmel, Loeschke & Schmidt, 1953a, b;Lambertsen, Stroud, Ewing & Mack, 1953). When respiration continues to slow, however, a point seems to be reached when CO2 clearance is no longer adequate and the CO2 pressure then rises, as occurred eventually in the majority of animals given chloralose and urethane.…”

“…Bean (1945) (Lambersten, Kough, Cooper, Emmel, Loeschke & Schmidt, 1953a, b;Lambertsen, Stroud, Ewing & Mack, 1953). When respiration continues to slow, however, a point seems to be reached when CO2 clearance is no longer adequate and the CO2 pressure then rises, as occurred eventually in the majority of animals given chloralose and urethane.…”

Determination of Tissue O2 Tensions by Hollow Visceral Tonometers: Effect of Breathing Enriched O2 Mixtures*

“…In the present study the breathing of an enriched O2 mixture resulted in the expected rise in the 02 tension of arterial blood without markedly or consistently affecting the 0°tension of the saline in the bladder. These observations are in contrast to other studies of tissue 02 tensions during the breathing of enriched°2 mixtures: in procedures involving measurements in skin and subcutaneous tissues by implanted electrodes or subcutaneous gas pockets (15)(16)(17)(18)(19), increases in tissue 02 tension of 10 to 50 mm Hg have been recorded. Although the accuracy of such procedures may be hampered by difficulties in calibrating electrodes or the pathological changes in the subcutaneous pocket, these different observations during 02 breathing may possibly be attributed to the different types of tissues being studied.…”

Changes in cardiac and respiratory rates, and in carbon dioxide pressure and pH of arterial blood, in anaesthetized rats exposed to oxygen under high pressure

“…The analyses, certainly, were made on arterial blood, and thus do not indicate directly the 'tissue' CO2 pressure. This whole problem has been fully discussed by Lambertsen and his colleagues (Lambertsen, Kough, Cooper, Emmel, Loeschke & Schmidt, 1953 a, b;Lambertsen, Stroud, Ewing & Mack, 1953). They criticized the very high values obtained by Campbell (1929) and H. J.…”