<i>Oxygen Toxicity. Effects in Man of Oxygen Inhalation at 1 and 3.5 Atmospheres Upon Blood Gas Transport, Cerebral Circulation and Cerebral Metabolism</i>

Lambertsen, CJ; Kough, R. H.; Cooper, David Y.; Emmel, G. L.; Loeschcke, H. H.; Schmidt, Carl F.

doi:10.1152/jappl.1953.5.9.471

Cited by 316 publications

(122 citation statements)

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“…This response has been observed directly [37] and has been inferred from quantitative studies in which cerebral blood flow was found to be reduced and cerebrovascular resistance was found to be increased [12,20,23]. The mechanism of the vasoconstrictive action is not known and has been attributed to a direct elfect of oxygen on vessel walls [29].…”

Section: Introductionmentioning

confidence: 70%

“…The inhalation of 80-f00% oxygen at ambient pressure has repeatedly been shown to result in a 10-15% reduction in cerebral blood flow, both in man and in experimental animals [12,14,20,23]. Some degree of hyperventilation usually accompanies the oxygen inhalation, with a resulting depression of arterial P co .,.…”

Section: Effects Of Chronic Oxygen Exposurementioning

confidence: 99%

“…Jt seems reasonable to conclude that average blood flow in the oxygen-exposed neonates is reduced by more than 12-15%, the magnitude of the effect of oxygen on average cerebral blood flow in adult animals and man [12,14,20,23].…”

Section: Effects Of Chronic Oxygen Exposurementioning

confidence: 99%

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Effect of Hyperoxia on the Cerebral Ciculation of the Newborn Puppy

Kennedy¹,

Grave²,

Jehle³

1971

Pediatr Res

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ExtractLocal cerebral blood flow (CBF) in the 2-day-old puppy ranged between 0.58 (superior olive) and 0.07 ml/g/min (centrum ovale), with average values in gray matter of the cerebral cortex, deep cerebral structures, and brain stem equal to 0.34, 0.38, and 0.45 ml/g/min, respectively. Animals of the same age, after being placed in oxygen for 1 hr, had a mean arterial oxygen tension (Pa o ,) of 349 mm Hg; arterial carbon dioxide tension (Pa co ,) did not change from the level seen in animals kept in air. The CBF of nearly all structures was 20-30% lower in the hyperoxic newborns than in control animals. In 3-week-old puppies, CBF ranged between 1.41 (inferior colliculus) and 0.20 ml/g/min (centrum ovale), with average values for gray matter in the cerebral cortex, deep cerebral structures, and brain stem equal to 0.61, 0.72, and 0.93 ml/ g/min, respectively. Puppies at this age breathing oxygen attained a mean Pa o , of 357 mm Hg; again, Pa C o 2 values were not different from those in air. The oxygen effect on CBF in the 3-week-old animals was less than had been found at 2 days, there being far fewer structures in which the difference was significant. The smallest differences were in white matter ( -11%). Continuous exposure to oxygen for 1 week, followed by removal of the puppies to air for 2-3 days, resulted in values for CBF which were comparable with those found in control animals. Speculation

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Section: Introductionmentioning

confidence: 70%

Section: Effects Of Chronic Oxygen Exposurementioning

confidence: 99%

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Effect of Hyperoxia on the Cerebral Ciculation of the Newborn Puppy

Kennedy¹,

Grave²,

Jehle³

1971

Pediatr Res

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“…The physiological and biochemical effects of hyperoxia and 4. Through the reversal of local hypoxia in target tissues [6,7].…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy—A Novel Treatment Modality in Oral Submucous Fibrosis: A Review

Gollamudi

et al. 2015

JCDR

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“…9 The flow of blood through the extracorporeal circulation, however, can be easily and accurately measured. There is abundant evidence that low flow rates, 25 of a blood flow through the extracorporeal circuit that is less than the cardiac output of the patient immediately preceding total bypass. The addition of blood to the combined system of the subject's vessels and the extracorporeal circuit is frequently resorted to in order to increase the blood flow and to raise the subject's blood pressure.…”

mentioning

confidence: 99%

The Lewis A. Conner Memorial Lecture

Gibbon

1959

Circulation

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AM GREATLY honored to have been selected to give the Lewis A. Conner Lecture before this association. I propose to discuss in this lecture some of the unsolved problems that have arisen from the use of extracorporeal blood circuits, a field in which I have long been interested. Twenty-four years ago at the Massachusetts General Hospital, we constructed an artificial heart-lung apparatus that was capable of maintaining the eardiorespiratory functions of cats for more than 4 hours with the pulmonary artery completely occluded.' A few years later, continuing this work at the Harrison Department of Surgical Research at the University of Pennsylvania, we were able to carry the entire cardiorespiratory functions of cats for as long as 26 minutes with prolonged healthy survival of the animals.2 World War II interrupted our work in this field, but it was resumed at the conclusion of the war. Six years were then spent in further experimental work in animals, with increasingly long periods of total bypass of the heart and lungs with survival,3-5, a decreasing mortality rate, and successful experiments in which atrial6 and ventricular7 septal defects were created and closed. There followed on May 6, 1953, the first successful open-heart operation on a human being in which the entire cardiorespiratory functions were maintained by an extracorporeal eirculationi.8 The heart and lungs were bypassed for 26 minutes while a large atrial septal defect was closed with sutures under direct vision. The patient, an 18-year-old girl, is now, 5 years later, healthy and leading a normal life. Today, as

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Oxygen Toxicity. Effects in Man of Oxygen Inhalation at 1 and 3.5 Atmospheres Upon Blood Gas Transport, Cerebral Circulation and Cerebral Metabolism

Cited by 316 publications

References 0 publications

Effect of Hyperoxia on the Cerebral Ciculation of the Newborn Puppy

Effect of Hyperoxia on the Cerebral Ciculation of the Newborn Puppy

Hyperbaric Oxygen Therapy—A Novel Treatment Modality in Oral Submucous Fibrosis: A Review

The Lewis A. Conner Memorial Lecture

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