<i>Orostachys japonicus</i> extract inhibits the lipopolysaccharide‐induced pro‐inflammatory factors by suppression of transcription factors

Lee, Hyeong-Seon

doi:10.1002/fsn3.1441

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…The dichloromethane extract (DCM) of O. japonicus component significantly inhibited the mRNA levels of pro-inflammatory mediators and cytokines in LPS-stimulated cells. The anti-inflammatory effects of DCM have been reported to inhibit inflammatory responses through the inhibition of NF-κB activation and MAPK signaling, which is regulated by proteins upstream of MAPK and PI3K/Akt signaling pathways [ 3 , 4 , 41 ]. The 1,4,6-β-Glcp glycosidic bond in OFP might be an important mechanism contributing to the immunostimulatory activity.…”

Section: Resultsmentioning

confidence: 99%

“…The Orostachys genera, containing twelve species, is widely distributed in China, Korea, Mongolia, and Russia. O. Japonicus is the most studied plant of Orostachys spp., and it is well known for its immunomodulatory, anticancer, anti-inflammatory, and antioxidant activities [ 1 , 2 , 3 , 4 ]. In comparison to O. japonicus , Orostachys fimbriata has been used as a medicinal plant in China for more than 1000 years.…”

Section: Introductionmentioning

confidence: 99%

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Purification, Structural Characterization, and Anti-Inflammatory Effects of a Novel Polysaccharide Isolated from Orostachys fimbriata

Fan

Yang

et al. 2021

Molecules

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The present study elucidated the structural characteristics and anti-inflammatory activity of a novel polysaccharide isolated from Orostachys fimbriata, which is a traditional Chinese medicinal plant. O. fimbriata polysaccharide (OFP) was extracted and subsequently purified by chromatography using a DEAE cellulose-52 and Sephadex G-75 column. The molecular weight was determined as 6.2 kDa. HPGPC and monosaccharide composition analysis revealed a homogeneous polysaccharide containing only Glc. Chromatography and spectral analysis showed that the possible chemical structure consisted of →4)-α-Glcp-(1→ and a small quantity of →4,6)-β-Glcp-(1→ in the main chain and →6)-β-Glcp-(1→, α-Glcp-(1→, and β-Glcp-(1→ in the side chain. Morphological analysis using scanning electron microscopy (SEM) and atomic force microscopy (AFM) indicated that OFP had a multi-branched structure, and the sugar chain molecules of polysaccharide appeared aggregated. OFP was found to exhibit anti-inflammatory activity by reducing the secretion of inflammatory factors in RAW264.7 cells and by decreasing the extent of xylene-induced ear swelling in mice.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Purification, Structural Characterization, and Anti-Inflammatory Effects of a Novel Polysaccharide Isolated from Orostachys fimbriata

Fan

Yang

et al. 2021

Molecules

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“…Inhibition of AP-1 Pathway. AP-1 is a pivotal factor in the regulation of inflammation by producing proinflammatory mediators and cytokines such as iNOS, COX-2, IL-1β, and IL-6 [15]. Phosphorylation of c-Jun, which is a member of the AP-1 family, induces translation of gene, and produces protein for TNF-α [16].…”

Section: Anti-inflammatory Activity Of the Pse Throughmentioning

confidence: 99%

Anti-Inflammatory Effects of Phlebia sp. Extract in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

Lim

Mun

Kim

et al. 2022

BioMed Research International

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Lichens are a life form in which algae and fungi have a symbiotic relationship and have various biological activities, including anti-inflammatory and antiproliferative activities. This is the first study to investigate the anti-inflammatory activity of a Phlebia sp. fungal extract (PSE) isolated from Peltigera neopolydactyla in lipopolysaccharide- (LPS-) stimulated RAW 264.7 macrophage. PSE reduced the production of the proinflammatory cytokine (tumor necrosis factor-α, interleukin-6, and interleukin-1β), chemokine (granulocyte-macrophage colony-stimulating factor), nitric oxide, and prostaglandin E2 in the LPS-stimulated RAW264.7 macrophages. Especially, PSE inhibits the phosphorylation of activator protein-1 (AP-1) signaling (c-Fos and c-Jun) and their upstream mitogen-activated protein kinase kinases/mitogen-activated protein kinases (MKK/MAPKs: MKK4, MKK7, and JNK) and finally reduced the production of the inflammatory cytokines. The inhibitory effects mainly act via suppressing JNK-mediated AP-1 rather than the NF-κB pathway. Furthermore, PSE inhibited the production of final inflammatory effector molecules involved in AP-1 signaling, including nitric oxide (NO) and prostaglandin E2 (PGE2). Here, we report that PSE has the potential to be developed as an anti-inflammatory agent.

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“…Still, its clearance capacity may wear off, causing prolonged or excessive inflammatory response [ 125 , 126 ]. Lee, 2020 [ 127 ] reported that AP-1 and IRF-3 in the cell nucleus are considered pivotal factors in regulating inflammation by producing pro-inflammatory mediators and cytokines. The bovine endometrium was reported to express a wide range of immune factors, including interleukin [IL] 1β-2, -6, -8, and -10, and tumor necrosis factors.…”

Section: Inflammatory Cytokines and Chemokines In Bovine Endometritismentioning

confidence: 99%

Modulation of Bovine Endometrial Cell Receptors and Signaling Pathways as a Nanotherapeutic Exploration against Dairy Cow Postpartum Endometritis

Oladejo

et al. 2021

Animals

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In order to control and prevent bovine endometritis, there is a need to understand the molecular pathogenesis of the infectious disease. Bovine endometrium is usually invaded by a massive mobilization of microorganisms, especially bacteria, during postpartum dairy cows. Several reports have implicated the Gram-negative bacteria in the pathogenesis of bovine endometritis, with information dearth on the potentials of Gram-positive bacteria and their endotoxins. The invasive bacteria and their ligands pass through cellular receptors such as TLRs, NLRs, and biomolecular proteins of cells activate the specific receptors, which spontaneously stimulates cellular signaling pathways like MAPK, NF-kB and sequentially triggers upregulation of pro-inflammatory cytokines. The cascade of inflammatory induction involves a dual signaling pathway; the transcription factor NF-κB is released from its inhibitory molecule and can bind to various inflammatory genes promoter. The MAPK pathways are concomitantly activated, leading to specific phosphorylation of the NF-κB. The provision of detailed information on the molecular pathomechanism of bovine endometritis with the interaction between host endometrial cells and invasive bacteria in this review would widen the gap of exploring the potential of receptors and signal transduction pathways in nanotechnology-based drug delivery system. The nanotherapeutic discovery of endometrial cell receptors, signal transduction pathway, and cell biomolecules inhibitors could be developed for strategic inhibition of infectious signals at the various cell receptors and signal transduction levels, interfering on transcription factors activation and pro-inflammatory cytokines and genes expression, which may significantly protect endometrium against postpartum microbial invasion.

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Orostachys japonicus extract inhibits the lipopolysaccharide‐induced pro‐inflammatory factors by suppression of transcription factors

Cited by 4 publications

References 22 publications

Purification, Structural Characterization, and Anti-Inflammatory Effects of a Novel Polysaccharide Isolated from Orostachys fimbriata

Purification, Structural Characterization, and Anti-Inflammatory Effects of a Novel Polysaccharide Isolated from Orostachys fimbriata

Anti-Inflammatory Effects of Phlebia sp. Extract in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

Modulation of Bovine Endometrial Cell Receptors and Signaling Pathways as a Nanotherapeutic Exploration against Dairy Cow Postpartum Endometritis

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