<i>Origanum vulgare</i>
 essential oil affects pathogens causing vaginal infections

Karaman, Maja; Bogavac, Mirjana; Radovanović, Bojan B; Sudji, Jan; Tešanović, Kristina; Janjušević, Ljiljana

doi:10.1111/jam.13413

Cited by 16 publications

(14 citation statements)

References 18 publications

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“…In certain regions of India, O. vulgare produces an essential oil rich in p-cymene (6.7–9.8%), γ-terpinene (12.4–14.0%), thymol (29.7–35.1%), and carvacrol (12.4–20.9%) ( Pande et al, 2012 ), whereas Turkish oregano essential oil together with the phenolic compounds thymol (15.66%) and carvacrol (24.52%) contain high amounts of linalool (50.53%) ( Ozkan & Erdoğan, 2011 ). Carvacrol (72.06%) and thymol (4.98%) were the major oil constituents in the EO of O. vulgare from Serbia too, followed by trans ‐caryophyllene (3.61%) and p ‐cymene (2.08%) ( Karaman et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Modification of light intensity influence essential oils content, composition and antioxidant activity of thyme, marjoram and oregano

Milenković¹,

Ilić²,

Šunić³

et al. 2021

Saudi Journal of Biological Sciences

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Thymus vulgaris L. (thyme), Origanum majorana L . (marjoram), and Origanum vulgare L . (oregano) were used to determine whether light modification (plants grown under nets with 40% shaded index or in un-shaded open field) could improve the quantity and quality of essential oils (EOs) and antioxidant activity. The yield of EOs of thyme, marjoram, and oregano obtained after 120 min of hydrodistillation was 2.32, 1.51, and 0.27 mL/100 g of plant material, respectively. At the same time under shading conditions plants synthetized more EOs (2.57, 1.68, and 0.32 mL/100 g of plant material). GC/MS and GC/FID analyses were applied for essential oils determinations. The main components of the thyme essential oil are thymol (8.05–9.35%); γ-terpinene (3.49–4.04%); p-cymene (2.80–3.60%) and caryophyllene oxide (1.54–2.15%). Marjoram main components were terpinene 4-ol (7.44–7.63%), γ-terpinene (2.82–2.86%) and linalool (2.04–2.65%) while oregano essential oil consisted of the following components: caryophyllene oxide (3.1–1.93%); germacrene D (1.17–2.0%) and (E)-caryophyllene (1.48–1.1%). The essential oil from thyme grown under shading (EC 50 value after 20 min of incubation) have shown the highest antioxidant activity – 0.85 mg mL −1 in comparison to marjoram and oregano (shaded plants EC 50 19.97 mg mL −1 and 7.02 mg mL −1 and unshaded, control plants EC 50 54.01 mg mL −1 and 7.45 mg mL −1 , respectively). The medicinal plants are a good source of natural antioxidants with potential application in the food and pharmaceutical industries. For production practice, it can be recommended to grow medicinal plants in shading conditions to achieve optimal quality parameters.

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Section: Discussionmentioning

confidence: 99%

Modification of light intensity influence essential oils content, composition and antioxidant activity of thyme, marjoram and oregano

Milenković¹,

Ilić²,

Šunić³

et al. 2021

Saudi Journal of Biological Sciences

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“…Artemia spp. (brine shrimps) have also been used as a biological model in three research papers [ 39 , 40 , 69 ], however, they are only suitable for ecotoxicity studies [ 136 ].…”

Section: Cytotoxicitymentioning

confidence: 99%

Anti-Candida Activity of Essential Oils from Lamiaceae Plants from the Mediterranean Area and the Middle East

et al. 2020

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Extensive documentation is available on plant essential oils as a potential source of antimicrobials, including natural drugs against Candida spp. Yeasts of the genus Candida are responsible for various clinical manifestations, from mucocutaneous overgrowth to bloodstream infections, whose incidence and mortality rates are increasing because of the expanding population of immunocompromised patients. In the last decade, although C. albicans is still regarded as the most common species, epidemiological data reveal that the global distribution of Candida spp. has changed, and non-albicans species of Candida are being increasingly isolated worldwide. The present study aimed to review the anti-Candida activity of essential oils collected from 100 species of the Lamiaceae family growing in the Mediterranean area and the Middle East. An overview is given on the most promising essential oils and constituents inhibiting Candida spp. growth, with a particular focus for those natural products able to reduce the expression of virulence factors, such as yeast-hyphal transition and biofilm formation. Based on current knowledge on members of the Lamiaceae family, future recommendations to strengthen the value of these essential oils as antimicrobial agents include pathogen selection, with an extension towards the new emerging Candida spp. and toxicological screening, as it cannot be taken for granted that plant-derived products are void of potential toxic and/or carcinogenic properties.

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“…Ethnopharmacological applications of oregano are diverse and include use of infusions for respiratory and digestive system, to relieve cough, sore throat and indigestion (Barros et al, 2010). Recently, O. vulgare EO has been proved as potent antimicrobial agent in a treatment of vaginal infections (Karaman et al, 2017). In fact, vagina infections caused by both bacteria and yeasts and recognized as vaginosis and vaginitis, represent a serious problem, particularly during pregnancy, due to increased susceptibility for infection owing to changes in immune system itself, hormonal oscillations and changes of normal physiological processes (Machado and Cerca, 2015).…”

Section: Introductionmentioning

confidence: 99%

Origanum vulgare L. essential oil effects on microbial pathogens causing vaginitis

Bogavac

Mišković

Krsmanović

et al. 2021

Zb Mat srp prir nauk

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Multidrug resistance of human isolates of bacteria that cause vaginal infections is one of most recent topics in scientific investigations along with the search for novel antimicrobial drugs originating from nature. Monitoring of antimicrobial activity of traditionally used herbal essential oils may give us basic perspective and directions for future studies design. Antimicrobial activity of commercial essential oil (EO) of Origanum vulgare against human clinical isolates of bacteria and Candida was determined by microdilution method, obtaining minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC) (CLSI protocol). Both investigated strains of Candida as well as all bacterial strains, except P. aeruginosa, showed susceptibility to investigated EO. The most susceptible strain was Gram positive S. aureus1 strain unlike S. aureus2 which indicates strain specificity. Both Gram negative E. coli isolates (E. coli1 and E. coli2) showed resistance to all tested antibiotics in this study, and susceptibility to oregano EO at 12.5 ?l/ml. GC/MS analysis identified a total of 35 components (96.13%) in commercial oregano EO, with the most dominant phenol carvacrol (64.12%). Our data suggest that oregano EO possess potent antimicrobial activity and that human vaginal isolates shows strain specificity in antimicrobial susceptibility.

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Origanum vulgare essential oil affects pathogens causing vaginal infections

Abstract: Examination of potential of the O. vulgare EO as a main antimicrobial constituent within vaginalettes in gynaecological practice.

Cited by 16 publications

References 18 publications

Modification of light intensity influence essential oils content, composition and antioxidant activity of thyme, marjoram and oregano

Modification of light intensity influence essential oils content, composition and antioxidant activity of thyme, marjoram and oregano

Anti-Candida Activity of Essential Oils from Lamiaceae Plants from the Mediterranean Area and the Middle East

Origanum vulgare L. essential oil effects on microbial pathogens causing vaginitis

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