NPM1‐mutated myeloid neoplasms are a unique entity not defined by bone marrow blast percentage
Georgina Gener‐Ricos,
Alex Bataller,
Juan Jose Rodriguez‐Sevilla
et al.
Abstract:IntroductionNPM1‐mutated (NPM1mut) myeloid neoplasms (MNs) with <20% bone marrow (BM) blasts (NPM1mut MNs<20) are uncommon, and their classification remains inconsistent.MethodsThe clinicopathologic features of 54 patients with NPM1mut MNs <20 were evaluated and compared with wild‐type NPM1 MNs <20 and NPM1mut MNs≥20, respectively.ResultsNPM1mut MNs had similar features regardless of blast percentage, except for higher IDH2 (29% vs 7%, p = .023) and FLT3 (70% vs 11%, p < .001) frequency in patie… Show more
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