<i>NOX4</i>, a new genetic target for anti‐cancer therapy in digestive system cancer

Tang, Chao; Gao, Youguang; Ge, Zhi Zheng

doi:10.1111/1751-2980.12651

Cited by 15 publications

(12 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NOX4 is presented in the literature as a therapeutic target in digestive cancer [35], including in colorectal cancer [36], being correlated among others with VEGF, MAPK and PI3K/AKT [35]. NOX4 inhibition promotes the immunotherapy response by overcoming cancer-associated fibroblast-mediated CD8 T-cell exclusion [37].…”

Section: Discussionmentioning

confidence: 99%

Epithelial–Mesenchymal Transition Gene Signature Related to Prognostic in Colon Adenocarcinoma

Busuioc

Ciocan-Cârtiţă

Braicu

et al. 2021

JPM

View full text Add to dashboard Cite

Colon adenocarcinoma (COAD) remains an important cause of cancer-related mortality worldwide. Epithelial–mesenchymal transition (EMT) is a key mechanism, promoting not only the invasive or metastatic phenotype but also resistance to therapy. Using bioinformatics approaches, we studied the alteration on EMT related genes and its implication on COAD prognostic based on public datasets. For the EMT mechanisms, two overexpressed genes were identified (NOX4 and IGF2BP3), as well as five downregulated genes (BMP5, DACT3, EEF1A2, GCNT2 and SFRP1) that were related to prognosis in COAD. A qRT-PCR validation step was conducted in a COAD patient cohort comprising of 29 tumor tissues and 29 normal adjacent tissues, endorsing the expression level for BMP5, as well as for two of the miRNAs targeting key EMT related genes, revealing upregulation of miR-27a-5p and miR-146a-5p. The EMT signature can be used to develop a panel of biomarkers for recurrence prediction in COAD patients, which may contribute to the improvement of risk stratification for the patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Epithelial–Mesenchymal Transition Gene Signature Related to Prognostic in Colon Adenocarcinoma

Busuioc

Ciocan-Cârtiţă

Braicu

et al. 2021

JPM

View full text Add to dashboard Cite

show abstract

“…However, the NRF2 activity increase is apparently unable to compensate oxidative stress and prevent the oxidative DNA damage. It is known that in contrast to the other NOXs, the NADPH oxidase NOX4 exists in the immediate environment of the nucleus and is involved in genomic instability as well as in cancer and other inflammation-related diseases [ 61 , 62 ]. This is how FF1genotoxic effect is realized.…”

Section: Discussionmentioning

confidence: 99%

Effects of Functionalized Fullerenes on ROS Homeostasis Determine Their Cytoprotective or Cytotoxic Properties

et al. 2020

View full text Add to dashboard Cite

Background: Functionalized fullerenes (FF) can be considered regulators of intracellular reactive oxygen species (ROS) homeostasis; their direct oxidative damage—as well as regulation of oxidant enzymes and signaling pathways—should be considered. Methods: Uptake of two water-soluble functionalized C70 fullerenes with different types of aromatic addends (ethylphenylmalonate and thienylacetate) in human fetal lung fibroblasts, intracellular ROS visualization, superoxide scavenging potential, NOX4 expression, NRF2 expression, oxidative DNA damage, repair genes, cell proliferation and cell cycle were studied. Results & conclusion: The intracellular effects of ethylphenylmalonate C70 derivative (FF1) can be explained in terms of upregulated NOX4 activity. The intracellular effects of thienylacetate C70 derivative (FF2) can be probably resulted from its superoxide scavenging potential and inhibition of lipid peroxidation. FF1 can be considered a NOX4 upregulator and potential cytotoxicant and FF2, as a superoxide scavenger and a potential cytoprotector.

show abstract

“…ADAM12 is highly expressed in cancer of gastric and is implicated in the malignant growth of GC cells (Carl-McGrath et al, 2005). NOX4 was found to be a new genetic target for anticancer therapy in digestive system cancer such as GC (Tang et al, 2018). Pathways are models containing the interaction, regulation, modification, and binding, etc.…”

Section: Construction and Verification Of A Tme-based Three-gene Prognostic Signaturementioning

confidence: 99%

Development and Validation of a Three-Gene Prognostic Signature Based on Tumor Microenvironment for Gastric Cancer

Wang

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

Gastric cancer (GC), which has high morbidity and low survival rate, is one of the most common malignant tumors in the world. The increasing evidences show that the tumor microenvironment (TME) is related to the occurrence and progression of tumors and the prognosis of patients. In this study, we aimed to develop a TME-based prognostic signature for GC. We first identified the differentially expressed genes (DEGs) related to the TME using the Wilcoxon rank-sum test in a training set of GC. Univariate Cox regression analysis was used to identify prognostic-related DEGs. To decrease the overfitting, we performed the least absolute shrinkage and selection operator (LASSO) regression to reduce the number of signature genes and obtained three genes (LPPR4, ADAM12, NOX4). Next, the multivariate Cox regression was performed to construct the risk score model, and a three-gene prognostic signature was developed. According to the signature, patients were classified into high-risk and low-risk groups with significantly different survival. The signature was then applied to three independent validated sets and obtained the same results. We conducted the time-dependent Receiver Operating Characteristic (ROC) curve analysis to evaluate our signature. We further evaluated the differential immune characters between high-risk and low-risk patients to reveal the potential immune mechanism of the impact on the prognosis of the model. Overall, we identified a three-gene prognostic signature based on TME to predict the prognosis of patients with GC and facilitate the development of a precise treatment strategy.

show abstract

NOX4, a new genetic target for anti‐cancer therapy in digestive system cancer

Cited by 15 publications

References 86 publications

Epithelial–Mesenchymal Transition Gene Signature Related to Prognostic in Colon Adenocarcinoma

Epithelial–Mesenchymal Transition Gene Signature Related to Prognostic in Colon Adenocarcinoma

Effects of Functionalized Fullerenes on ROS Homeostasis Determine Their Cytoprotective or Cytotoxic Properties

Development and Validation of a Three-Gene Prognostic Signature Based on Tumor Microenvironment for Gastric Cancer

Contact Info

Product

Resources

About