I. Notes on insects bred from the bark and wood of the American larch

Blackman, M. W.; Stage, H. H.

doi:10.5962/bhl.title.40923

Cited by 16 publications

(14 citation statements)

References 5 publications

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“…Sex counts show a primary sex ratio of 1/2 (27,30); I know of only one possible exception (31). In response to the male's attractant scent, several females (but not more than eight) colonize the nuptial chamber of a successful male, are mated by him, and construct radiating egg galleries.…”

Section: Sex Ratios With Polygynymentioning

confidence: 99%

Extraordinary Sex Ratios

Hamilton

1967

Science

3,294

2,322

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Section: Sex Ratios With Polygynymentioning

confidence: 99%

Extraordinary Sex Ratios

Hamilton

1967

Science

3,294

2,322

View full text Add to dashboard Cite

“…3a and c). Although sucrose gradient ultracentrifugation is the method of choice for separation of organelles [19], some non-microneme contamination does occur and the microneme fraction in this case was also found to contain a trace of rhoptry protein (Fig. 3b).…”

Section: Screening Pmf Datamentioning

confidence: 92%

Defining the protein repertoire of microneme secretory organelles in the apicomplexan parasite Eimeria tenella

et al. 2003

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The apicomplexan pathogen Eimeria causes coccidiosis, an intestinal disease of chickens, which has a major welfare and economic impact on the poultry industry. There is an urgent need to identify molecules that are rational targets for drug design and novel vaccines against coccidiosis. Apicomplexan secretory organelles, including micronemes and rhoptries, are essential for invasion of the host intestinal epithelium and establishment of parasitism. However, relatively little is known about the precise molecular function of these organelles, partly because few organelle proteins have been characterized. In this study, proteomics tools have been harnessed to define the protein repertoire of micronemes. Purified microneme proteins from Eimeria tenella sporozoites were excised from two-dimensional (2-D) gels and analyzed using matrix-assisted laser desorption/ionization-time of flight-mass spectrometry (MALDI-TOF-MS) and chemically assisted fragmentation (CAF)-MALDI with de novo sequencing. Peptide mass profiles were searched against the NCBI non-redundant (nr) database and against Eimeria-specific databases using the Mascot search algorithm, resulting in the identification of 37 of 96 spots excised from the 2-D gels. In addition, we have found CAF-MALDI to be a useful adjunct for identifying proteins, without the need for tandem MS. This global approach to protein characterization will be vital to gain greater understanding of the processes involved in apicomplexan host cell invasion.

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“…This finding was confirmed in a larger series of tumors observed by the same group where 61% of the functioning malignant pancreatic endocrine tumors were found to secrete a-hCG in men and 38% of the tumors in women. 29 In addition, a-hCG secretion was reported to occur in three of ten patients with malignant gastrinomas but in none of 16 patients suffering from benign gastrinomas. 30 The highest incidence (85%) of elevated serum levels of hCG in the presence of a malignant pancreatic endocrine tumor was found in the 16 patients observed by Oberg and Wide.3' These authors found P-hCG to be predominantly secreted (69% of malignant pancreatic endocrine tumors).…”

Section: Fig 2 A-hcg-immunoreactivity In the Cytoplasm Of Several Tmentioning

confidence: 99%

Glycoprotein-hormone alpha-chain production by pancreatic endocrine tumors: A specific marker for malignancy. Immunocytochemical analysis of tumors of 155 patients

Heitz

Kasper

Klöppel

et al. 1983

Cancer

108

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Human chorionic gonadotropin (hCG) or its α‐ and β‐subunits have been proposed as specific quantitative markers for malignant pancreatic endocrine tumors.1 Since proof of malignancy of pancreatic endocrine tumors is difficult early in the course of the illness, we tested retrospectively a series of 157 pancreatic endocrine tumors of 155 patients for α‐ or β‐subunits of hCG by immunocytochemistry. Human CG‐α‐immunoreactive cells were present in 42 of 56 (75%) functioning malignant pancreatic endocrine tumors but in only one, possibly benign, glucagonoma of 67 functioning benign tumors, in only one of 17 nonfunctioning malignant and in none of 17 nonfunctioning benign tumors. No β‐hCG‐immunoreactivity was localized in the tumors. Human CG‐α‐appears to be a reliable quantitative and qualitative marker for malignancy in functioning pancreatic endocrine tumors.

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I. Notes on insects bred from the bark and wood of the American larch

Abstract: Entered at the Postofflce at Syracuse as second-class mall matter

Cited by 16 publications

References 5 publications

Extraordinary Sex Ratios

Extraordinary Sex Ratios

Defining the protein repertoire of microneme secretory organelles in the apicomplexan parasite Eimeria tenella

Glycoprotein-hormone alpha-chain production by pancreatic endocrine tumors: A specific marker for malignancy. Immunocytochemical analysis of tumors of 155 patients

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