ninna nannalinks circadian and homeostatic sleep drive inDrosophila
Anne Petzold,
Giorgio F. Gilestro
Abstract:Sleep is under control of two processes, circadian and homeostatic regulation, but little is known about how these two processes integrate. Here, we identify a Drosophila gene, ninna nanna, encoding two alternatively spliced isoforms: Ninna and Nanna. Both proteins encode aldo-keto reductases and are expressed in different, yet interconnected neurons. One isoform, ninna, encodes an aldo-keto reductase with predicted affinity for NADP(H) and is expressed in key circadian pacemaker neurons, the s-LNvs. The secon… Show more
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