<i>Nigella sativa</i> and its active constituent thymoquinone in oral health

Al-Attass, Safia A.; Zahran, Fatheya; Turkistany, Shereen A.

doi:10.15537/smj.2016.3.13006

Cited by 65 publications

(74 citation statements)

References 46 publications

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“…Furthermore, we found other two compounds claasified into diacylglycerols (1,2‐dioleylglycerol, and 1,3‐dioleylglycerol) from M. ciliatum . These compounds, which exist in several vegetable and seed oil, are well known for their functional roles in medicinal fields (AlAttas, Zahran, & Turkistany, ; Huang, Altimova, Myers, & Ebersole, ; Lopes, Daletos, Proksch, Andrade, & Valentão, ). However, and to the best of our knowledge, these compounds are very rare in higher plants.…”

Section: Discussionmentioning

confidence: 99%

Isolates fromMonechma ciliatumseeds' extract hamperedPorphyromonas gingivalishemagglutinins

et al. 2019

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Porphyromonas gingivalis is a major periodontitis pathogen that produces several virulence factors including hemagglutinins. These proteins, which are vital molecules, allow P. gingivalis to uptake iron and heme by attaching, aggregating, and lysing erythrocytes. In this study, we evaluated the inhibitory activity of the aqueous extract of Monechma ciliatum seeds against the hemagglutination activity of P. gingivalis. M. ciliatum is a Sudanese medicinal herb that grows in arid and semi‐arid lands of tropical Africa. The water extracted from dry powdered seeds was partitioned using ethyl acetate followed by reversed‐phase chromatography, thin‐layer chromatography, ESI‐MS, and NMR analysis resulting in the isolation of four compounds identified as oleic acid, coumarin, 1,2‐dioleoylglycerol, and 1,3‐dioleoylglycerol with MICs of 15–100 μg/ml against hemagglutination. We believe that the isolation and purification of these compounds will expand the application of M. ciliatum as a natural therapeutic or preventative agent. Practical applications Monechma ciliatum or black mahlab is a famous medicinal plant that grows in some parts of arid and semi‐arid areas of tropical Africa including western Sudan. Despite its nutritional and traditional medical applications, no studies have evaluated its anti‐hemagglutination activity against periodontal pathogens. In this study, four active compounds (oleic acid, coumarin, 1,2‐dioleoylglycerol, and 1,3‐dioleoylglycerol) were isolated and identified from an aqueous extract of M. ciliatum seeds. The isolated compounds revealed high levels of inhibitory activity against all hemagglutinin agents secreted by Porphyromonas gingivalis. This evidence of inhibitory activity will encourage the application of M. ciliatum effectively as a functional food or therapeutic agent to prevent periodontal diseases in the early stages.

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Section: Discussionmentioning

confidence: 99%

Isolates fromMonechma ciliatumseeds' extract hamperedPorphyromonas gingivalishemagglutinins

et al. 2019

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“…Since the biological activities of the essential oil of black cumin seeds and compound 1 comprise antibacterial and deodorizing activities, these seeds represent a good botanical resource for the development of new oral health care products 20 . In addition, the safety of black cumin seed essential oil has already been demonstrated by animal experiments 9 .…”

Section: Resultsmentioning

confidence: 99%

Deodorizing Substance in Black Cumin (<i>Nigella sativa</i> L.) Seed Oil

Nakasugi¹,

Murakawa²,

Shibuya³

et al. 2017

J. Oleo Sci.

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“…It has also anti-aging, mitigating, and protective effects [3]. Both NS and TQ can be used in oral health and hygiene [40].…”

Section: Topical Applicationsmentioning

confidence: 99%

A comprehensive and updated review on the pharmacological activities and phytochemistry of Nigella sativa L.

Islam¹

2016

Adv. Biomed. Pharma.

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Nigella sativa L. (NS) has a number of important biological activities, such as antioxidant, anti-inflammatory, antibacterial, antifungal, anti-viral, anti-parasitic and anti-protozoal, cytotoxic, anticancer, neuro-, gastro-, cardio-, hetapto-and nephroprotective activities. In addition, the NS exerts beneficiary effects on reproductive, pulmonary and immune systems as well as in diabetes mellitus (DM), fertility (male and female), breast cancer, dermatological complications, dehydration, dyspepsia, and osmotic balance and so on. Among the isolated constituents, thymoquinone (TQ) is a vastly studied phytochemical in NS. A number of reports suggest that, the NS may be one of the potential herbs in health promotion. This review paper will discuss the detailed and mechanistic aspects of the biological activity of N. sativa along with the reported phytoconstituents.

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Nigella sativa and its active constituent thymoquinone in oral health

Cited by 65 publications

References 46 publications

Isolates fromMonechma ciliatumseeds' extract hamperedPorphyromonas gingivalishemagglutinins

Isolates fromMonechma ciliatumseeds' extract hamperedPorphyromonas gingivalishemagglutinins

Deodorizing Substance in Black Cumin (<i>Nigella sativa</i> L.) Seed Oil

A comprehensive and updated review on the pharmacological activities and phytochemistry of Nigella sativa L.

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