Abstract:Background & Aims: The alternative (non-canonical) nuclear factor-kB (NF-kB) signalling pathway predominantly regulates the function of the p52/RelB heterodimer. Germline Nfkb2 deficiency in mice leads to loss of p100/p52 protein and offers protection against a variety of gastrointestinal conditions, including azoxymethane/dextran sulfate sodium (DSS)-induced colitis-associated cancer and lipopolysaccharide (LPS)-induced small intestinal epithelial apoptosis. However, the common underlying protective mecha… Show more
“…NFκB2-deficient mice show IgA downregulation and significantly elevated IgM in the small intestine mucosa. The lamina propria of the small intestine of NFκB2 deficient mice had fewer CD138 + PCs that produced IgA ( 148 ). Almaden et al.…”
Section: The Nfκb Signaling System In Plasmablast/plasma Cell Develop...mentioning
confidence: 99%
“…NFkB2-deficient mice show IgA downregulation and significantly elevated IgM in the small intestine mucosa. The lamina propria of the small intestine of NFkB2 deficient mice had fewer CD138 + PCs that produced IgA (148). Almaden et al showed that germline NFkB2 heterozygosity enhanced antibody production and proposed that NFkB2 heterozygosity leads to disruption of IkBd and sustains cRel activity leading to enhance B cell proliferation and subsequent antibody production (16).…”
Section: The Nfkb Signaling System In Plasmablast/plasma Cell Develop...mentioning