<i>Neisseria meningitidis</i> disease-associated clones in Amazonas State, Brazil

Silva, Luciete A.; Coronato, Beatriz; Schlackman, Jessica L.; Marsh, Jane W.; Ezeonwuka, Chinelo; Fernandes, Andréia C L; Souza, Victor Costa de; Silva, Lirna S da; Amorim, Elaine F Q de; Naveca, Felipe Gomes; Albuquerque, Bernardino Cláudio de; Amaral, Alcirene; Souza, Ana L S; Carvalho-Costa, Filipe Aníbal; Mustapha, Mustapha M.; Harrison, Lee H.; Barroso, David E.

doi:10.1080/23744235.2018.1459829

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…Our data show that there is no prevalent circulation of a single MenB cc in Brazil, which has currently been observed for serogroup B IMD epidemiology in some European countries and not in North America [ 15 , 17 , 34 ]. cc213, cc35, and cc461 have previously been reported in Argentina, Australia, Colombia, Paraguay, Tunisia, Turkey, and Europe [ 23 , 22 , 35 – 41 ]. Additionally, clonal diversity exhibiting a decline in cc41/44 and cc32 and an increase in cc269 and cc461 was observed in the Republic of Ireland over 19 years [ 39 ].…”

Section: Discussionmentioning

confidence: 98%

“…Additionally, the predominant circulation of serogroup B strains carrying fHbp peptide 1 for decades in Brazil has been described [ 13 , 22 ], and a strong association between fHbp subB/var1 and peptide 1 within cc32 is well described in the literature [ 48 ]. We have shown the circulation of fHbp subB/A (var1/2–3) in almost equal proportions in recent years, in contrast to reports in China, where subA/var2 is prevalent [ 49 ], and in the United States and some European countries, where subB/var1 has prevailed among serogroup B IMD strains [ 50 – 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, data on the distribution and diversity of these vaccine antigens in Latin America are scarce [ 13 , 22 , 23 ]. Therefore, we aimed to evaluate the genetic lineages, the diversity of vaccine antigens, and the alleles types of antimicrobial resistance-associated genes in serogroup B IMD strains isolated in Brazil from 2016 to 2018 using whole-genome sequencing.…”

Section: Introductionmentioning

confidence: 99%

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Genomic surveillance of Neisseria meningitidis serogroup B invasive strains: Diversity of vaccine antigen types, Brazil, 2016-2018

et al. 2020

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Background Neisseria meningitidis serogroup B remains a prominent cause of invasive meningococcal disease (IMD) in Brazil. Because two novel protein-based vaccines against serogroup B are available, the main purpose of this study was to provide data on the diversity and distribution of meningococcal vaccine antigen types circulating in Brazil. Methodology Genetic lineages, vaccine antigen types, and allele types of antimicrobial-associated resistance genes based on whole-genome sequencing of a collection of 145 Neisseria meningitidis serogroup B invasive strains recovered in Brazil from 2016 to 2018 were collected. Results A total of 11 clonal complexes (ccs) were identified among the 145 isolates, four of which were predominant, namely, cc461, cc35, cc32, and cc213, accounting for 72.0% of isolates. The most prevalent fHbp peptides were 24 (subfamily A/variant 2), 47 (subfamily A/variant 3), 1 (subfamily B/variant 1) and 45 (subfamily A/variant 3), which were predominantly associated with cc35, cc461, cc32, and cc213, respectively. The NadA peptide was detected in only 26.2% of the isolates. The most frequent NadA peptide 1 was found almost exclusively in cc32. We found seven NHBA peptides that accounted for 74.5% of isolates, and the newly described peptide 1390 was the most prevalent peptide exclusively associated with cc461. Mutated penA alleles were detected in 56.5% of the isolates, whereas no rpoB and gyrA mutant alleles were found. Conclusion During the study period, changes in the clonal structure of circulating strains were observed, without a predominance of a single hyperinvasive lineage, indicating that an epidemiologic shift has occurred that led to a diversity of vaccine antigen types in recent years in Brazil.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genomic surveillance of Neisseria meningitidis serogroup B invasive strains: Diversity of vaccine antigen types, Brazil, 2016-2018

et al. 2020

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“…Vaccination is the key method to prevent IMD [5]; however, improvements in nutrition, health, education and living conditions also have considerable power to control infectious diseases [31]. Silva et al [32] reported IMD incidence reduction in the Amazonas state of the North region, during the 10 years before MCC implementation. We can hypothesise that different HDI evolution and living conditions may have contributed to the regional differences of IMD evolution among the Brazilian administrative regions.…”

Section: Discussionmentioning

confidence: 99%

Impact of meningococcal C conjugate vaccine on incidence of invasive meningococcal disease in an 18‐year time series in Brazil and in distinct Brazilian regions

Cruz

Camargos

Nascimento‐Carvalho

2022

Tropical Med Int Health

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Objective: To evaluate the impact of meningococcal C conjugate (MCC) vaccine in Brazil. Methods:Ecological study assessing all invasive meningococcal disease (IMD) and meningococcal C disease (MenC) cases reported in all age groups, from 2001 to 2019.MCC was implemented in 2010. Data were collected on the DATASUS platform.Joinpoint regression was performed to assess the annual percent change (APC) of the incidence rate.Results: Invasive meningococcal disease incidence decreased in all Brazilian regions from 2001 onwards, without apparent additional reduction attributable to MCC vaccine in the North, Northeast and South. The higher and statistically significant APC reduction in all age groups, in the North and South, and in children <5 years, in the Northeast,

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“…In France, 26 % of the isolates belonged to CC 32 between 2006 and 2015 [20]. In Brazil, 72 % of the meningococcal strains belong to CC 32 [43]. In Spain, 95.83 % of the cases belong to CC 32, it is therefore a globally frequent hyper-invasive clone [44].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological profile of Neisseria meningitidis in Casablanca, Morocco: 2010–2019

Mouss

Razki

Hong

et al. 2020

Access Microbiology

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Surveillance of invasive meningococcal diseases (IMD) must be carried out regularly and continuously in order to detect the emergence of strains of reduced susceptibility to antibiotics for therapeutic and prophylactic use and the appearance of new invasive clones. Molecular-typing approaches allow reliable traceability and powerful epidemiological analysis. This is an epidemiological study of Neisseria meningitidis causing meningitis in Casablanca, Morocco. The grouping was confirmed by PCR mainly on the isolates from cerebrospinal fluid (CSF). A total of 245 confirmed isolates of N .meningitidis were obtained between 2010 and 2019 of which 93 % are of group B. Overall, 24 % of all the isolates have a reduced susceptibility to penicillin G, but no resistance to penicillin G has been reported. All the isolated strains are susceptible to third-generation cephalosporins (3GCs). Genotyping by multilocus sequence typing (MLST) of a selection of 18 strains showed that the majority of isolates belong to the invasive clonal complex CC 32(9/18) followed by the CC 41/44(3/18).

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Neisseria meningitidis disease-associated clones in Amazonas State, Brazil

Cited by 6 publications

References 25 publications

Genomic surveillance of Neisseria meningitidis serogroup B invasive strains: Diversity of vaccine antigen types, Brazil, 2016-2018

Genomic surveillance of Neisseria meningitidis serogroup B invasive strains: Diversity of vaccine antigen types, Brazil, 2016-2018

Impact of meningococcal C conjugate vaccine on incidence of invasive meningococcal disease in an 18‐year time series in Brazil and in distinct Brazilian regions

Epidemiological profile of Neisseria meningitidis in Casablanca, Morocco: 2010–2019

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