<i>Neisseria</i>

Tønjum, Tone

doi:10.1002/9781118960608.gbm00981

Cited by 4 publications

(2 citation statements)

References 329 publications

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“…The opportunistic pathogens Actinomyces [35]and Escherichia/Shigella (or closely related Brenneria/Pseudescherichia) were also more abundant in microbiota of patients from the main group. Proportion of Neisseria mucosa, an inhabitant of intestinal mucus layer [36], and Parvimonas micra, which is specifically able to degrade mucin [37,38], was lower for the participants of the main group. Relative abundance of Megasphaera micronuciformis was also decreased in patients with higher disease severity [39,40].…”

Section: Microbial Composition Of Intestinal Washing Samples Is Linked To Clinical Statusmentioning

confidence: 81%

Microbial Community of Small Intestine in Acute Severe Pancreatitis Patients: a Pilot Study

Киселев

Kurenkov

Петриков

et al. 2021

Preprint

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Purpose of the study: to describe the composition of the microbiota of the initial sections of the small intestine in patients with severe necrotizing acute pancreatitis. Objectives of the study: 1. Determine the composition of the microbiota of the initial sections of the small intestine upon admission to the ICU; 2. Determine the differences in the composition of the microbiota of the initial sections of the small intestine, depending on the timing of the onset of the disease. Introduction. Disturbance of intestinal homeostasis is a leading factor in the pathogenesis and progression of systemic inflammation in patients with severe acute pancreatitis. The development of systemic complications occurs due to both mesenteric hypoperfusion and dysregulation of intestinal motility, and the destruction of the intestinal barrier, with the translocation of bacterial bodies and their substrates. Which increases the risk of developing POI and increasing mortality. With the advent of methods for high-throughput sequencing of microbiome samples - for example, in the 16S rRNA format - the possibilities for studying the structure of microbial communities have significantly expanded. In this regard, there is more and more evidence of the relationship between the state of human health and microflora inhabiting various parts of the body. Materials and methods. The study included 7 patients with a diagnosis of severe necrotizing acute pancreatitis (6 men, 1 woman), the mean age was 54.1 ± 14.4 years. The patients were divided into two groups. Group 1 (n = 4) included patients admitted 2-4 days after the onset of a pain attack. Group 2 (n = 3) - patients admitted no later than 24 hours from the onset of the disease. The bacterial composition of jejunal wash samples was studied using 16S RNA sequencing. The severity of the condition was assessed using the integral scales APACHE II, SOFA, SAPS II. In patients of the main group, APACHE II was 22 ± 2.83 points (18; 24), SOFA - 6.8 ± 0.5 points (6; 7), SAPSII - 32.9 ± 6.4 points (24.7; 40), in patients of the comparison group, APACHE II is 18.0 ± 3.7 points (12; 22), SOFA - 4.0 ± 2.6 points (2; 7), SAPSII - 24.4 ± 5.0 points (20.9; 30.1). Material was collected at the time of installation of a sterile multifunctional intestinal catheter for Treitz's ligament, no later than 12 hours from the moment of admission to the ICU. At the time of sampling, patients were not receiving antibiotic therapy. Results. A more severe course was associated with a reduced representation in the microbiome of the species Nesseria mucosa and Parvimonas micra inhabiting the mucosal layer, as well as Megasphaera micronuciformis. The share of Streptococcus genera (S. rubneri / parasanguinis / australis species) and Actinomyces and a number of genera from the Enterobacteriaceae family in such patients, on the contrary, was higher.

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Section: Microbial Composition Of Intestinal Washing Samples Is Linked To Clinical Statusmentioning

confidence: 81%

Microbial Community of Small Intestine in Acute Severe Pancreatitis Patients: a Pilot Study

Киселев

Kurenkov

Петриков

et al. 2021

Preprint

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“…It is also notable that Neisseria species tend to be associated with mammals and birds, such as N. canis with dog, N. animaloris with racoon dog, N. zalophi with sea lion, N. arctica with goose, etc. (see Figure 4 ), as inhabitants of the mucous membranes of animals ( Tønjum, 2015 ). These observations suggest the possibility that, although speculative, the blood-sucking lice may acquire the Neisseria -allied bacteria from their host animals either casually or as commensal associates, and some of them have established an obligatory association as observed in H. acanthopus ( Říhová et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Endosymbiotic bacteria of the boar louse Haematopinus apri (Insecta: Phthiraptera: Anoplura)

et al. 2022

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Insects exclusively feeding on vertebrate blood are usually dependent on symbiotic bacteria for provisioning of B vitamins. Among them, sucking lice are prominent in that their symbiotic bacteria as well as their symbiotic organs exhibit striking diversity. Here we investigated the bacterial diversity associated with the boar louse Haematopinus apri in comparison with the hog louse Haematopinus suis. Amplicon sequencing analysis identified the primary endosymbiont predominantly detected from all populations of H. apri with some minor secondary bacterial associates. Sequencing and phylogenetic analysis of bacterial 16S rRNA gene confirmed that the endosymbionts of the boar louse H. apri, the hog louse H. suis and the cattle louse Haematopinus eurysternus form a distinct clade in the Gammaproteobacteria. The endosymbiont clade of Haematopinus spp. was phylogenetically distinct from the primary endosymbionts of other louse lineages. Fluorescence in situ hybridization visualized the endosymbiont localization within midgut epithelium, ovarial ampulla and posterior oocyte of H. apri, which were substantially the same as the endosymbiont localization previously described in H. suis and H. eurysternus. Mitochondrial haplotype analysis revealed that, although the domestic pig was derived from the wild boar over the past 8,000 years of human history, the populations of H. apri constituted a distinct sister clade to the populations of H. suis. Based on these results, we discussed possible evolutionary trajectories of the boar louse, the hog louse and their endosymbionts in the context of swine domestication. We proposed ‘Candidatus Haematopinicola symbiotica’ for the distinct clade of the endosymbionts of Haematopinus spp.

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Host phenotype and microbiome vary with infection status, parasite genotype, and parasite microbiome composition

et al. 2022

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A growing literature demonstrates the impact of helminths on their host gut microbiome. We investigated whether the stickleback host microbiome depends on ecoevolutionary variables by testing the impact of exposure to the cestode parasite Schistocephalus solidus with respect to infection success, host genotype, parasite genotype, and parasite microbiome composition. We observed constitutive differences in the microbiome of sticklebacks of different origin, and those differences increased when sticklebacks exposed to the parasite resisted infection. In contrast, the microbiome of successfully infected sticklebacks varied with parasite genotype. More specifically, we revealed that the association between microbiome and immune gene expression increased in infected individuals and varied with parasite genotype. In addition, we showed that S. solidus hosts a complex endomicrobiome and that bacterial abundance in the parasite correlates with expression of host immune genes. Within this comprehensive analysis we demonstrated that (i) parasites contribute to modulating the host microbiome through both successful and unsuccessful infection, (ii) when infection is successful, the host microbiome varies with parasite genotype due to genotype‐dependent variation in parasite immunomodulation, and (iii) the parasite‐associated microbiome is distinct from its host and impacts the host immune response to infection.

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Neisseria

Cited by 4 publications

References 329 publications

Microbial Community of Small Intestine in Acute Severe Pancreatitis Patients: a Pilot Study

Microbial Community of Small Intestine in Acute Severe Pancreatitis Patients: a Pilot Study

Endosymbiotic bacteria of the boar louse Haematopinus apri (Insecta: Phthiraptera: Anoplura)

Host phenotype and microbiome vary with infection status, parasite genotype, and parasite microbiome composition

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