<i>N,N</i>
            -Dioctadecyl-
            <i>N′,N′</i>
            -Bis(2-Hydroxyethyl) Propanediamine: Antiviral Activity and Interferon Stimulation in Mice

Hoffman, William W.; Korst, J.J.; Niblack, J. F.; Cronin, Timothy H.

doi:10.1128/aac.3.4.498

Cited by 59 publications

(15 citation statements)

References 15 publications

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“…Some low-molecular-weight inducers, such as tilorone hydrochloride (18), quinacrine (10), BL-20803 (24), CP-20961 (12), and cycloheximide (30), were also examined for their antiviral effects, with unencouraging results. Tilorone hydrochloride (18), an orally active inducer in mice, and CP-20961, which has a high therapeutic index (300) in the infection model of vesicular stomatitis virus, showed little, if any, protective activity against influenza virus infection in mice (12). Cycloheximide induced circulating interferon only at the level at which it coincidentally inhibited protein synthesis in animals (30).…”

mentioning

confidence: 99%

Antiviral and Interferon-Inducing Activity of a New Glutarimide Antibiotic, 9-Methylstreptimidone

Saito

Suzuki

Sasaki

et al. 1976

Antimicrob Agents Chemother

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The antiviral effect of 9-methylstreptimidone (9-MS) was examined in mice infected with mouse-adapted influenza A2 (H2N2) virus. Both a single and continuous prophylactic administration of 9-MS protected mice from virus infection, and comparison between the minimal effective and the 50% lethal dose gave a therapeutic index of 60. When the treatment was started after infection, however, no antiviral effect was demonstrated. After a single intraperitoneal administration of 9-MS, a highly potent virus-inhibitory factor was detected in the lungs (10 h later) and the sera (16 h later) of uninfected mice, which was assumed to be an interferon on the basis of the biological characteristics. These results suggest that the protective activity of the antibiotic is due to interferon induction in mice.

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mentioning

confidence: 99%

Antiviral and Interferon-Inducing Activity of a New Glutarimide Antibiotic, 9-Methylstreptimidone

Saito

Suzuki

Sasaki

et al. 1976

Antimicrob Agents Chemother

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“…Fourteen mice were injected ip with 1500 pg (75 mg/kg) DDA each. At different intervals (4,6,8,12,14, and 16 hr after injection) blood, peritoneal fluid, and PEC were collected. PEC were incubated in Eagle's medium without serum for 24 hr at 37°C and the supematants were also titrated for the presence of interferon.…”

Section: Antibody Formation After Infectionmentioning

confidence: 99%

“…N,ZGdioctadecyl-N',N'-bis(2-hydroxyethyl) propanediamine (CP-20,96 1) is an antiviral drug in mice and humans (4,5). Parental injection ofthis compound protected mice against otherwise lethal infections with encephalomyocarditis (EMC) virus or SFV.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of delayed-type hypersensitivity and induction of interferon by the lipophilic agents DDA and CP-20,961

Kraaijeveld

Snippe

Harmsen

et al. 1982

Cellular Immunology

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The lipophilic amines dimethyl dioctadecyl ammonium bromide (DDA) and N,iVdioctadecyl-N:N'-bis(2-hydroxyethyl)propanediamine 961) are compared on their capacities to induce interferon, nonspecific protection to viral infection, and enhancement of delayed-type hypersensitivity (DH). DDA, a well-known adjuvant for the induction of DH is a moderate interferon inducer like CP-20,96 1. On the other hand, CP-20.96 1, a known interferon inducer and resembling in structure DDA, is shown to enhance DH to inactivated Semliki Forest virus (WV). Nonspecific protection to challenge with a lethal dose of either SFV or encephalomyocarditis (EMC) virus was induced on injection of both compounds.

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“…Several chemically defined, nonpolymeric, relatively low-molecular-weight compounds have been reported to stimulate interferon production in laboratory models (4,5,7,8,10). These interferon inducers represent a diversity of chemical structures, and all differ structurally from an inducer discovered in our laboratory.…”

mentioning

confidence: 99%

Stimulation of Murine Interferon by a Substituted Pyrimidine

Nichol

Weed

Underwood

1976

Antimicrob Agents Chemother

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2-Amino-5-bromo-6-methyl-4-pyrimidinol (U-25,166) induced high levels of circulating interferon in mice when administered either parenterally or orally. Peak titers of interferon were found in the serum between 6 and 12 h after inoculation of the drug. Lower but significant levels of interferon were found in rat serum after administration of U-25, 166 by either the intraperitoneal or oral route, and good levels of circulating interferon were observed in cats after oral treatment. Repeated intraperitoneal doses (50 mg/kg) of U-25, 166 protected mice against intranasal encephalomyocarditis virus challenge. The minimal effective acute oral dose for antiviral activity was approximately 250 mg/kg. This was also the minimal dose that produced detectable levels of interferon. Maximum tolerated doses in mice were four to six times the minimal effective doses. A single oral treatment was protective in mice against challenge virus inoculated 24 h later. The compound protected mice from challenge with high levels of encephalomyocarditis virus, up to 20,000 mean lethal doses. Antiviral activity in mice was retained when certain minor substitutions were made in the U-25,166 structure.

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N,N -Dioctadecyl- N′,N′ -Bis(2-Hydroxyethyl) Propanediamine: Antiviral Activity and Interferon Stimulation in Mice

Cited by 59 publications

References 15 publications

Antiviral and Interferon-Inducing Activity of a New Glutarimide Antibiotic, 9-Methylstreptimidone

Antiviral and Interferon-Inducing Activity of a New Glutarimide Antibiotic, 9-Methylstreptimidone

Enhancement of delayed-type hypersensitivity and induction of interferon by the lipophilic agents DDA and CP-20,961

Stimulation of Murine Interferon by a Substituted Pyrimidine

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