N-(Phenylsulfonyl)Benzenesulfonamide: A New Organocatalyst for One-Pot, Solvent-Free Synthesis of Biginelli’s 3,4-Dihydropyrimidine-2(1H)-Thiones

Advances in Biginelli reaction: A comprehensive review

“…In 2022, Chaturbhuj et al discovered an efficient method for the synthesis of 3,4-dihydropyrimidine-2(1H)ones/thiones via Biginelli reaction. 48 Under solvent-free conditions, they carried out the reaction at 90 C and generated DHPM derivatives with a significant yield using aldehyde, ethyl acetoacetate, and urea/thiourea as model substrates and N-(phenylsulfonyl)benzenesulfonamide as catalyst (Scheme 28). The results of the experiment showed that benzaldehyde had the best yield and shortest reaction time with thiourea.…”

Recyclable photocatalyst perovskite as a single-electron redox mediator for visible-light-driven photocatalysis gram-scale synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones in air atmosphere

“…A multitude of catalysts may be implemented in the synthetic production of 3,4-dihydropyrimidin-2-(1 H )-ones/thiones, including Cu/Cu 2 O@g-C 3 N 4 19 , N -(phenylsulfonyl)benzene sulfonamide 20 , h -BN/Fe 3 O 4 /Co 21 , Na 2 eosin Y 22 , copper(II)sulfamate 23 , bakers, yeast 24 , hydrotalcite 25 , hexaaquaaluminium (III) tetrafluoroborate 26 , TBAB 27 , copper (II) tetrafluoroborate 28 , [Btto][ p -TSA] 29 , triethylammonium acetate 30 , saccharin 31 , caffeine 32 , zirconium(IV)-salophen perfluorooctanesulfonate 33 , H 3 [PW 12 O 40 ] 34 , Dioxane-HCl 35 , 4CzIPN 36 , H 4 [W 12 SiO 40 ] 37 , Zr(H 2 PO 4 ) 2 38 , GO-chitosan 39 , and sodium dodecyl sulfate 40 . The prolonged reaction times, the exorbitant cost of reagents, tumultuous reaction mechanisms, and minimal product yields, foray into waste management concerns.…”