N-tert-Butyl-2-{2-[2-(4-chlorophenyl)-4-hydroxy-1-(5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-N-(4-methoxyphenyl)acetamido}-2-(4-methoxyphenyl)acetamide methanol monosolvate: single-crystal X-ray diffraction study and Hirshfeld surface analysis

Abstract

The title compound, C36H37ClN4O7·CH3OH, which crystallizes as a methanol solvate, may possess biological activity, which is inherent for a natural peptide or protein. In the crystal, molecules of the title compound form hydrogen-bonded tetramers with the solvate molecules acting as bridges as a result of the O—H...O and N—H...O intermolecular hydrogen bonds. Hirshfeld surface analysis was used to study the different types of intermolecular interactions whose contributions are: H...H = 53.8%, O...H/H...O = 19.0%, C...H/H...C = 14.8%, Cl...H/H...Cl = 5.3%, N...H/H...N = 3.2%.

Temperature-Controlled Diastereoselective Doebner/Ugi Tandem Reaction

“…X-ray diffraction analysis of diastereomer B (compound 7d) (Figure 2) was described in our previous work. 27 Diastereomer A of compound 7d was crystallized as a non-solvated structure in contrast to the diastereomer B, which was found to be a methanol solvate in the crystal structure. Comparison of the molecular structures of these diastereomers revealed only one significant difference related to the conformation of the substituent on the C7 atom.…”